A review of thermal-chemical conversion of lignocellulosic biomass in China

Biomass, a renewable, sustainable and carbon dioxide neutral resource, has received widespread attention in the energy market as an alternative to fossil fuels. Thermal-chemical conversion of biomass to produce biofuels is a promising technology with many commercial applications. This paper reviewed the state-of-the-art research and development of thermal-chemical conversion of biomass in China with a special focus on gasification, pyrolysis, and catalytic transformation technologies. The advantages and disadvantages, potential of future applications, and challenges related to these technologies are discussed. Conclusively, these transformation technologies for the second-generation biofuels with using non-edible lignocellulosic biomass as feedstocks show prosperous perspective for commercial applications in near future.     

The behaviour of Dutch fresh water ecologists in response to environmental concern

Due to the rise of environmental concern ecologists have been asked for advice more frequently since the late 1960s. This article discusses how the changing relationship between ecologists and society has affected the behaviour of one particular group of ecologists, namely Dutch fresh water ecologists, by focussing on their behaviour towards job market control and public interest activities. The analysis has been based on interviews with 65 Dutch fresh water ecologists together with an analysis of their publications.In contrast with American ecologists, Dutch fresh water ecologists have made little effort to control their job market by formal arrangements such as formulating a code of ethics and certification procedures. Secondly, Dutch fresh water ecologists generally conceive of their own role in contributing to the solution of environmental problems in relation to that of the environmentalists by doing good research and reliable advisory work. Although a significant number of researchers also address lay publics by writing popular articles and/or holding lectures, only a minority actively participates in environmental politics.     

国际蝗虫灾害的防治策略和技术：现状与展望

简要地综述了国际上对蝗虫灾害管理策略与控制技术的发展现状,包括：监测与预警技术、化学防治、生物防治、综合管理对策以及目前的研究热点方向。比较分析了国际、国内蝗虫发生及其治理中存在问题的异同。国际上控制蝗虫灾害的理论、技术、措施、对策,对中国有重要的借鉴作用。一般来说, 控制蝗虫灾害的IPM计划中应该包括：在策略上,强调提前预防压制优于后期灭杀处理;在规律认识上,重视基础生物学和生态学的研究,并将之模型化和标准化;在测报方法上,积极发展和改善监测预警技术水平,将地理信息系统(GIS）和遥感（RS）技术集成引入到防治决策的整体系统中,使信息能够快速、准确地传递;在防治手段上,注意新型防治药剂和施药技术的研究开发和集成,增加用药效果;在天敌利用和环境保护方面,充分认识和评估自然天敌的控制作用,正确地估计防治效益和挽回的损失,重视对环境价值的评价;同时加强多个地区间的联合与协调。     

Gene therapy in The Netherlands: highlights from the Low Countries

Gene therapy is an active research area in The Netherlands and Dutch scientists involved in fundamental and clinical gene therapy research significantly contribute to the progresses made in this field. This ranges from the establishment of the 293, 911 and PER.C6 cell lines, which are used worldwide for the production of replication-defective adenoviral vectors, to the development of targeted viral vectors and T lymphocytes as well as of non-viral vectors. Several milestones have been achieved in Dutch clinical gene therapy trials, including the first treatment worldwide of patients with adenosine deaminase deficiency with genetically corrected hematopoietic stem cells in collaboration with French and British scientists. Until now, about 230 patients with various diseases have been treated with viral and non-viral gene therapy in this country. Ongoing and upcoming Dutch clinical trials focus on the translation of new developments in gene therapy research, including the restoration of genetic defects other than SCID, and the use of oncolytic adenoviruses and targeted T cells for the treatment of cancer. The growing commercial interest in Dutch clinical gene therapy is reflected by the involvement of two Dutch companies in ongoing trials as well as the participation of Dutch clinical centres in large phase III international multicenter immuno-gene therapy trials on prostate cancer sponsored by an American company. Translational gene therapy research in The Netherlands is boosted at a governmental level by the Dutch Ministry of Health via a dedicated funding programme. This paper presents an overview on milestones in Dutch basic gene therapy research as well as on past, present and future clinical gene therapy trials in The Netherlands.     

中草药生物质炼制工程

目前我国中药产业面临资源紧张、药材利用率低、加工过程浪费严重等问题,究其原因主要是单一药效成分利用、加工转化技术落后所致。针对上述问题,从生物质炼制角度,综述了实现中草药资源高效利用的原料预处理、提取、转化及残渣后处理等4个关键单元操作中主要技术的研究进展,并指出中草药生物质炼制工程发展趋势与前景。     

Plants as extreme environments? Ni-resistant bacteria and Ni-hyperaccumulators of serpentine flora

During recent years there has been an increasing interest in the bacterial communities occurring in unusual, often extreme, environments. On serpentine outcrops around the world, a high diversity of plant species showing the peculiar features of metal hyperaccumulation is present. These metal hyperaccumulators have received much attention for their potential biotechnological exploitation in phytoremediation processes, but also as unusual, extreme habitats for the associated bacterial flora, which could reveal novel details concerning bacterial adaptation. This paper will briefly focus on the research topics that have been addressed to date on bacteria associated with serpentine plants and aims to provide a state of the art and to present possible future directions for research which could lead to new insights on microbial adaptation and evolution, and potentially applied in technologies for sustainable use and remediation of contaminated land.     

The commercialization of genome-editing technologies

The emergence of new gene-editing technologies is profoundly transforming human therapeutics, agriculture, and industrial biotechnology. Advances in clustered regularly interspaced short palindromic repeats (CRISPR) have created a fertile environment for mass-scale manufacturing of cost-effective products ranging from basic research to translational medicine. In our analyses, we evaluated the patent landscape of gene-editing technologies and found that in comparison to earlier gene-editing techniques, CRISPR has gained significant traction and this has established dominance. Although most of the gene-editing technologies originated from the industry, CRISPR has been pioneered by academic research institutions. The spinout of CRISPR biotechnology companies from academic institutions demonstrates a shift in entrepreneurship strategies that were previously led by the industry. These academic institutions, and their subsequent companies, are competing to generate comprehensive intellectual property portfolios to rapidly commercialize CRISPR products. Our analysis shows that the emergence of CRISPR has resulted in a fivefold increase in genome-editing bioenterprise investment over the last year. This entrepreneurial movement has spurred a global biotechnology revolution in the realization of novel gene-editing technologies. This global shift in bioenterprise will continue to grow as the demand for personalized medicine, genetically modified crops and environmentally sustainable biofuels increases. However, the monopolization of intellectual property, negative public perception of genetic engineering and ambiguous regulatory policies may limit the growth of these market segments.     

21世纪害虫管理的一些特征展望

分析了近年来国内外IPM研究的进展 ,认为未来的害虫管理是以作物的控害作用为中心 ,以农田生态系统或区域性生态系统为对象 ,以大量信息管理为基础 ,以发展新技术 (转基因作物和昆虫性信息素 )和农民参与为重点 ,以生态调控为手段 ,以持续发展为方向。从而使害虫管理提高到一个新的境界     

中国药用植物可持续利用战略框架简述

China is the birth-place of Traditional Chines Medicine (TCM) and has a rich diversity of medicinal plant resources. With the rapid increase in consumer demands for crude drugs and natural health products, many medicinal plant species are threatened with extinction from overexploitation and habitat destruction. To ensure the sustainable use of medicinal plant resources, we discuss in this article, a conservation framework consisting of conservation strategies, cultivation practices and various technologies. Conservation strategies include establishing in-situ and ex-situ conservation centers, setting up government policies and regulations, establishing methods for resource surveying and trade monitoring and establishing and enforcing Good Agricultural Practices (GAP). In terms of technologies, we use a remote multi-level sensing system and DNA barcoding technologies as examples to demonstrate their roles in the conservation and sustainable use of medicinal plant resources in China.     

Synthetic fragments of plant polysaccharides as tools for cell wall biology

A sustainable bioeconomy that includes increased agricultural productivity and new technologies to convert renewable biomass to value-added products may help meet the demands of a growing world population for food, energy and materials. The potential use of plant biomass is determined by the properties of the cell walls, consisting of polysaccharides, proteins, and the polyphenolic polymer lignin. Comprehensive knowledge of cell wall glycan structure and biosynthesis is therefore essential for optimal utilization. However, several areas of plant cell wall research are hampered by a lack of available pure oligosaccharide samples that represent structural features of cell wall glycans. Here, we provide an update on recent chemical syntheses of plant cell wall oligosaccharides and their application in characterizing plant cell wall-directed antibodies and carbohydrate-active enzymes including glycosyltransferases and glycosyl hydrolases, with a particular focus on glycan array technology.     

Recent advances and applications of the lipolytic activity of Carica papaya latex

The lipolytic enzymes of Carica papaya have been the subjects of a growing research activity in the last years due to the structural characteristics, substrate specificity over lipases from different sources and the wide availability from the large worldwide figures of papaya agro-waste. This review attempts to present an inclusive discussion of the recent advances of these lipolytic enzymes starting from findings related to their structure and mechanism and later examining the most employed pretreatments and the general optimized parameters for its use. Furthermore, individual sections comprising applications in glycerolipid modification, catalysis for the synthesis of non-glycerolipid products and the kinetic resolution of racemic compounds are discussed. The attractive features of CPL cited in this literature survey serve as an invitation for other research groups interested in the development of new and sustainable biochemical technologies.     

Social aspects for sustainability assessment of technologies—challenges for social life cycle assessment (SLCA)

Purpose

Technologies can contribute to sustainable development (e.g., improving living conditions) and at the same time cause sustainability problems (e.g., emissions). Decisions on alternative technologies should thus ideally be based on the principle to minimize the latter. Analyzing environmental, economic, and social aspects related to technologies supports decisions by identifying the “more sustainable” technology. This paper focuses on social issues. First, it discusses the applicability of the social life cycle assessment (SLCA) guidelines for a comparative technology analysis, taking the example of two case studies in developing countries. Indicating technologies as “sustainable” also means that they are indeed operated over the expected lifetime, which, in development projects, is often not guaranteed. Consequently, social aspects related to implementation conditions should be considered in an SLCA study as well. Thus, a second focus is laid on identifying appropriate indicators to address these aspects.

Methods

First, the SLCA guidelines were examined with regard to applying this product-related approach to two real case studies (analysis of technologies/plants for water supply and for decentralized fuel production) for a comparative technology analysis. Suitable indicators are proposed. To address the second focus, a literature research on technology assessment and implementation in developing countries was conducted. Moreover, socioeconomic studies in the investigation areas of the case studies were consulted. Based on this, indicators addressing implementation conditions were identified from the SLCA guidelines and additional literature.

Results and discussion

The study shows social issues and indicators found in the SLCA guidelines and considered suitable for a comparative technology analysis in the case studies. However, for a sustainability assessment of technologies, especially in developing countries, further indicators are required to address technology implementation conditions. A set of additional social indicators like reported trust in institutions or fluctuation of personnel is proposed. Though these indicators were derived based on specific case studies, they can also be suggested to other technologies and are not necessarily limited to developing countries.

Conclusions

The study pointed out that an application of the SLCA guidelines considering the whole life cycle was not (yet) feasible for the case studies considered. This is mainly due to the lack of data. Regarding technology implementation, it was examined which indicators are available in this SLCA approach and which could additionally be integrated and applied. This is relevant as a potential contribution of technologies to sustainable development can only be achieved when the technologies are successfully implemented.     

Exploring the application of high-throughput genomics technologies in the field of maternal-embryo communication

Deciphering the complex molecular dialogue between the maternal tract and embryo is crucial to increasing our understanding of pregnancy failure, infertility problems and in the modulation of embryo development, which has consequences through adulthood. High-throughput genomic technologies have been applied to look for a holistic view of the molecular interactions occurring during this dialogue. Among these technologies, microarrays have been widely used, being one of the most popular tools in maternal-embryo communication. Today, next generation sequencing technologies are dwarfing the capabilities of microarrays. The application of these new technologies has broadened to almost all areas of genomics research, because of their massive sequencing capacity. We review the current status of high-throughput genomic technologies and their application to maternal-embryo communication research. We also survey next generation technologies and their huge potential in many research areas. Given the diversity of unanswered questions in the field of maternal-embryo communication and the wide range of possibilities that these technologies offer, here we discuss future perspectives on the use of these technologies to enhance maternal-embryo research.     

3S技术及其在生态学研究中的应用

随着国民经济的迅速发展,人类对资源环境的需求越来越高,及时、准确、动态地获取资源现状及其变化信息对资源、生态环境的保护及可持续发展具有重要意义。本文综述了3S技术即遥感(RS)、地理信息系统(GIS)、全球定位系统(GPS)的概念、特点及其研究进展,探讨了3S技术在景观生态学及景观异质性研究、空间格局分析与模拟的应用;并对3S技术在群落生态学、植被调查、生物多样性研究、植被制图以及其它生态学领域中的应用作了展望。     

The scope of mission-orientation in Dutch fresh-water ecology

In response to growing concern about environmental problems ecologists have engaged in a variety of mission-oriented efforts in which they claim to have taken into account the objective of helping to solve environmental problems in their research strategies or research programmes. The significance of these efforts is evaluated here in terms of both the theoretical development of the field of ecology and its orientation towards social objectives.Three examples of mission-orientation are analyzed on the basis of a case-study of Dutch fresh-water ecology; (1) ecosystems research within the framework of the International Biological Programme; (2) landscape ecology, and (3) ecological research on the management of fresh-water resources. These examples demonstrate that in principle the scope of missionorientation in ecology can be broad. In Dutch fresh-water ecology, however, two specific approaches have become particularly institutionalized. The ecologists tended to opt either for theory-centered approaches close to the type of research carried out by ecologists developing the field regardless of any societal mission or for problem-centered approaches without much emphasis on theory development. Types of mission-orientation which can be placed between these extremes have been established only to a limited extent in Dutch fresh-water ecology.     

Advanced Biofuels from Thermochemical Processing of Sustainable Biomass in Europe

Biofuels can play an important role in decreasing the use of fossil fuels, in particular in the transport sector, which absorbs about 30 % of the EU energy requirements. This review illustrates the motivations behind biofuel development, the government incentives and regulations and the current approaches on sustainable biomass conversion in Europe, and provides an overview on the major steps involved in thermochemical processes and on the issues challenging their deployment at large scale, with particular emphasis on the pyrolysis of biomass and bio-oil upgrading using conventional oil refinery settings. Distribution of sustainable biofuels in Europe and future prospects towards achieving success of transport biofuels were also addressed. The literature suggests that importing biofuels and increasing the cost of CO₂ to at least €60/t CO₂ will be necessary to meet the renewable obligation targets in the EU. Algae represent the future feedstock for biofuels but currently are limited by their high production costs and high N content. Pyrolysis is cost competitive compared to other technologies such as fermentation and gasification, but the quality of bio-oils requires upgrading mainly to lower their oxygen content and enhance their thermal stability. The recent advances in bio-oil upgrading using catalytic cracking and hydro-treating are very promising for the future deployment of advanced biofuels in the coming decades. However, significant investments in applied research and demonstration are still required to meet the 2020/2030 biofuel targets.     

Green batteries for clean skies: Sustainability assessment of lithium-sulfur all-solid-state batteries for electric aircraft

The use of novel battery technologies in short-haul electric aircraft can support the aviation sector in achieving its goals for a sustainable development. However, the production of the batteries is often associated with adverse environmental and socio-economic impacts, potentially leading to burden shifting. Therefore, this paper investigates alternative technologies for lithium–sulfur all-solid-state batteries (LiS-ASSBs) in terms of their contribution to the sustainable development goals (SDGs). We propose a new approach that builds on life cycle sustainability assessment and links the relevant impact categories to the related SDGs. The approach is applied to analyze four LiS-ASSB configurations with different solid electrolytes, designed for maximum specific energy using an electrochemical model. They are compared to a lithium–sulfur battery with a liquid electrolyte as a benchmark. The results of our cradle-to-gate analysis reveal that the new LiS-ASSB technologies generally have a positive contribution to SDG achievement. However, the battery configuration with the best technical characteristics is not the most promising in terms of SDG achievement. Especially variations from the technically optimal cathode thickness can improve the SDG contribution. A sensitivity analysis shows that the results are rather robust against the weighting factors within the SDG quantification method.     

A practical perspective on ulvan extracted from green algae

Researchers have many times turned their attention to nature and biological processes to develop novel technologies and materials. In a medical perspective, nature-based products are believed to be a strategic alternative approach to the use of fully synthetic materials, particularly in the design of medical devices. In the past decades, marine organisms have become the focus of considerable attention as potential sources of valuable materials. The sustainable exploitation and valorisation of natural marine resources constitutes a highly attractive and strategic platform for the development of novel biomaterials, with both economic and environmental benefits. In this context, algae are known to synthesise large quantities of polysaccharides and are well established sources of these particularly interesting molecules, many of which are known for their applicability in the design of biomaterials. Agar, carrageenan and alginates are some of the most known examples, and their uses can range from food to biomedical applications. However, few of the world’s available seaweed species are used commercially. Among the three main divisions of macroalgae (Chlorophyta, Phaeophyta and Rhodophyta), the green algae remain largely unexploited in this biomedical arena. While the demand for novel materials and technologies increases, so does the research of unexploited marine green algae including its unique polysaccharide ulvan.     

我国城市可持续发展能力评估指标的元数据分析与管理

在我国大力推动城市可持续发展,推进国家可持续发展实验区建设的同时,采用何种评估方法和数据开展城市可持续发展能力评估是需要重点解决的问题。近年来兴起的元数据理论与技术在解决评估数据质量控制方面被视为是一种行之有效的方法。针对我国现阶段使用的一些城市可持续发展能力评估指标体系的特点,通过深入剖析每一个指标数据的来源、获取手段、适用方法等特征,提出从软件工程学思路研发城市可持续发展能力评估元数据管理系统的具体方法,帮助可持续发展实验区高效获取和管理评估所需数据信息;以"十二五"科技支撑计划项目"城市可持续发展能力评估及信息管理关键技术研究与示范"中所建立的元数据规范,对其所包含的"数据发布日期"、"数据发布形式"、"空间范围"、"时间范围(起始时间、结束时间)"、"统计频率"、"数据安全限制分级"、"数据志说明"、"在线资源链接地址"和"数据统计单位信息(单位名称、联络人、联系电话、单位地址、邮件地址)"共14项为评估数据的关键元数据项,以此追踪对标的评估数据。并通过量化数据质量评分法针对数据质量在运用元数据追踪法前后的评价结果对比发现,被评估指标的数据质量在获得元数据支持时,其数据可靠性、可比性和可持续性方面的评价分值都获得了十分显著的改善。研究认为采用元数据理论在控制和保障城市可持续发展能力评估数据质量方面具有优势作用,开发有针对性的城市可持续发展能力评估元数据管理系统能够有效提高评估数据的综合评价结果。