中国汉族人群DNA酶I基因多态性与不稳定性心绞痛的关系

目的：探讨脱氧核糖核酸酶（IDNA酶I）基因多态性与汉族人群不稳定性心绞痛（unstable angina pectoris,UAP）易感性的关系。方法：以196例UAP患者为病例组,排除冠心病的297例体检者为对照组,应用PCR及PCR-限制性片段长度多态（PCR-RFLP）分析DNA酶I基因8外显子单核苷酸多态位点A2317G及4内含子56bp可变串联重复序列（HumDN1）多态性;协方差分析A2317G、HumDN1各基因型与UAP患者血脂的关系,将年龄、性别、高血压、糖尿病及吸烟作为协变量;x2检验分析UAP患者冠脉血管病变支数与DNA酶I基因型的关系。结果：UAP组与对照组A2317G、HumDN1各基因型及等位基因分布无明显统计学差异（P〉0.05）,两组DNA酶I单体型分布亦无差异。UAP患者DNA酶I各基因型血脂水平、冠脉血管病变支数的差异无明显统计学意义,所有P值均〉0.05。结论：DNA酶I基因多态性与中国汉族人群不稳定心绞痛及其血脂水平无明显相关性。     

血清γ-谷氨酰转移酶与冠心病影响因素及血管病变严重程度的相关性研究

目的:探究血清γ-谷氨酰转移酶(GGT)水平与冠心病影响因素及患者血管病变严重程度之间的相关性。方法:选取2013年7月至2017年10月于我院经冠状动脉造影确诊为冠心病的61例患者为实验组,将其按照临床症状分为稳定性心绞痛组(下简称A组,20例)、不稳定性心绞痛组(下简称B组,21例)和急性心肌梗死组(下简称C组,20例),另选取同期于我院进行冠脉造影检查确诊为非冠心病的30例患者为对照组,检测和比较四组患者的空腹血糖(FBG)、总胆固醇(TC)、甘油三酯(TG)、收缩压(SBP)、舒张压(DBP)、尿酸等水平,而分析GGT与危险因素、冠脉Gensini评分的相关性。结果:(1)实验组患者血清FBG、TC、TG、SBP、DBP、尿酸水平均高于对照组患者,差异具有统计学意义(P0.05);(2)GGT水平与冠心病上述危险因素呈正相关性(r=0.236、0.351、0.316、0.239、0.301、0.395,P=0.035、0.000、0.000、0.034、0.001、0.000);(3)四组患者GGT及Gensini评分均按照C组B组A组对照组的趋势变化,且各组间对比差异具有统计学意义(P0.05);(4)冠心病患者血清GGT水平与Gensini评分呈正相关性(r=0.681,P=0.000)。结论:冠心病患者血清GGT水平与血清FBG、TC、TG、SBP、DBP、尿酸水平及血管病变的严重程度均呈显著正相关,其可能作为预测冠心病患者病变程度的参考指标。     

中国汉族人群DNA酶Ⅰ基因多态性与不稳定性心绞痛的关系

目的:探讨脱氧核糖核酸酶Ⅰ(DNA酶Ⅰ)基因多态性与汉族人群不稳定性心绞痛(unstable angina pectoris,UAP)易感性的关系.方法:以196例UAP患者为病例组,排除冠心痛的297例体检者为对照组,应用PCR及PCR-限制性片段长度多态(PCR-RFLP)分析DNA酶Ⅰ基因8外显子单核苷酸多态位点A2317G及4内含子56bp可变串联重复序列(HumDN1)多态性;协方差分析A2317G、HumDN1各基因型与UAP患者血脂的关系,将年龄、性别、高血压、糖尿病及吸烟作为协变量;x2检验分析UAP患者冠脉血管病变支数与DNA酶Ⅰ基因型的关系.结果:UAP组与对照组A2317G、HumDN1各基因型及等位基因分布无明显统计学差异(P＞0.05),两组DNA酶Ⅰ单体型分布亦无差异.UAP患者DNA酶Ⅰ各基因型血脂水平、冠脉血管病变支教的差异无明显统计学意义,所有P值均＞0.05.结论:DNA酶Ⅰ基因多态性与中国汉族人群不稳定心绞痛及其血脂水平无明显相关性.     

冠心病患者血清Alarin和Chemerin的表达水平与血管病变严重程度的相关性研究

摘要 目的：研究冠心病患者血清中Alarin和趋化素（Chemerin）表达水平和其血管病变严重程度的相关性。方法：随机选择2017年1月1日至2021年1月1日在本院接受冠状动脉造影检查的冠心病患者112作为研究对象,并选择86例健康体检者作为对照组。其中冠心病患者行冠状动脉造影检查,病变程度由Gensini评分确定,血清Alarin和Chemerin水平使用酶联免疫吸附试验测定。结果：与对照组健康受试者相比,冠心病患者的体重指数、收缩压、舒张压、总胆固醇、甘油三酯和低密度脂蛋白胆固醇、高密度脂蛋白胆固醇水平明显升高（P<0.05）;冠心病患者血清Alarin水平明显高于对照组（0.62±0.18 vs. 0.41±0.19 μg/L,P<0.05）。另外,冠心病患者血清Chemerin水平明显高于对照组（124.7±19.3 vs. 88.6±10.9 ng/mL,P<0.05）。血清Alarin和Chemerin水平分别与Gensini评分呈显著正相关（r=0.51,P<0.05;r=0.62,P<0.05）。多因素Logistic回归分析显示,血清Alarin和Chemerin水平是冠脉造影冠心病的独立预测因素（OR=0.91,95%CI：0.90-0.92;P<0.05和OR=0.93,95 %CI：0.90-0.95;P<0.05）。结论：本研究显示,冠心病患者血清Alarin和Chemerin水平明显高于健康受试者,且与冠心病严重程度呈显著正相关。     

TNFa-308基因启动子多态性与新疆维吾尔族人乙型肝炎易感性的相关性研究

目的：研究TNF-α基因单核苷酸多态性（SNP）308G—A位点与新疆地区维吾尔族人乙型肝炎之间的关系。方法：以聚合酶链式反应－限制性内切酶长度多态性（PCR-RFLP）技术,对120例乙肝患者和120例正常对照者TNF—α基因SNP308多态性位点进行基因分型。结果：SNP308多态性位点G／G基因型和G／A基因型频率在病例组为77％和23％,正常对照组为88％和12％,2组基因型和等位基因频率分布差异有显著性（p〈0．05）。结论：TNF—α基因启动子308多态性位点与新疆维吾尔族人乙肝有明显相关性。     

心外膜脂肪厚度与冠脉病变严重程度的相关性研究

目的:探讨心外膜脂肪组织(Epicardial adipose tissue,EAT)厚度与冠状动脉病变严重程度的相关性。方法:收集167名符合纳入标准的患者,根据冠状动脉造影(coronary arteriography,CAG)结果分2组:正常冠脉组(65例)及冠心病冠脉病变组(≥1支冠状动脉病变狭窄程度≥50%)(102例)。同期经胸超声心动图测量EAT厚度,并依据CAG图像计算Gensini评分、Syntax评分。结果:冠脉正常组和冠心病病变组EAT厚度分别为(3.89±0.2 mm)、(6.19±1.19 mm),冠心病病变组显著高于冠脉正常组(P0.001)。进一步分析EAT的厚度分别为5 mm、5-7 mm和7 mm时,Gensini评分分别为:7.21±7.73,37.80±29.55和62.77±27.26;Syntax评分分别为:7.13±7.70,19.71±7.27和24.95±4.31。EAT的厚度与Gensini评分(r=0.621;P0.001)、Syntax评分(r=0.689;P0.001)呈正相关。结论:心外膜脂肪组织厚度与冠状动脉狭窄的复杂程度评分Gensini评分、Syntax评分呈正相关。     

中国汉人纤维蛋白原β链基因-148C／T,-455G／A多态性与冠心病关系的Meta分析

有关中国汉人纤维蛋白原β链基因多态性与冠心病关系的研究屡见报道,但不同的研究之间结果存在一定的差异．本研究根据相应的入选条件,通过文献检索收集中国汉人纤维蛋白原β链基因-148C／T,455G／A多态性与冠心病关系的病例-对照研究,剔除不符合要求的文献,对入选文献进行一致性检验并根据检验结果进行数据合并荟萃（Meta）分析,计算总OR值．共13篇文献符合要求纳入研究,其中7篇关于-148C／T多态性研究包括1488例冠心病患者和1234例对照人群,9篇关于-455G／A多态性的研究包括1023名患者和1081名对照者,入选研究无明显发表偏倚,入选研究的同质性检验显示各研究结果间存在明显的异质性,数据合并结果显示-148C／T多态性位点C／T＋T／T比C／C的OR值为1．31,95％CI为0．94-1．84（P=0．11）,-455G／A多态性位点G／A＋A,A比G／G的OR值为1．75,95％CI为1．24-2．46（P=0．001）．本研究的初步结果显示纤维蛋白原B链基因-455G／A多态性与中国汉人冠心病易感性相关,-455A等位基因可能是冠心病的遗传易感基因,-148C／T基因多态性与中国汉人冠心病易感性无明显关系．     

臂踝脉搏波传导速度与冠状动脉病变程度的相关性研究

目的：探讨臂踝脉搏波传导速度（brachio—anklepulsewavevelocity,baPWV）与冠状动脉粥样硬化狭窄程度的相关性。方法：选择198例行冠脉造影的患者为研究对象,根据冠状动脉管腔狭窄程度分为非冠心病组（对照组,50例）和冠心病组（148例）;并将冠-22病组分为单支病变组（48例）、双支病变组（56例）及多支病变组（44例）,所有患者均采用动脉硬化检测仪检测baPWV,观察各组baPWV值及Gensini积分的变化,并对其行相关性分析。结果：CAD组多支病变、双支病变、单支病变亚组及对照组冠状动脉Gensini积分分别为45．06±7．27、30．83±4．50、24．83±4．94和13．75±1．74,baPWV值分别为2．13±0．32、1．68±0．14、1．12±0．13和0．93±0．17m／s,组间差异具有统计学意义（P〈0．05）。冠心病组baPWV值与冠状动脉Gensini积分呈正相关。结论：baPWV值与冠状动脉粥样硬化的病变范围密切相关,可作为诊断冠心病和预测其病变严重程度的辅助指标。     

支架术后再发急性冠脉综合征患者冠脉病变程度的影响因素分析

目的:探讨既往支架术后再次发生急性冠脉综合征患者冠状动脉病变严重程度与冠心病危险因素的相关性。方法:收集本院2017年7月至2018年7月收治的支架术后再次因急性冠脉综合征住院的107例患者,根据冠脉造影结果进行Gensini评分,按照评分高低将冠脉病变严重程度分为轻度(0-6分)、中度(7-14分)、重度组(14分),对冠心病危险因素进行研究,并探讨支架术后再次发生急性冠脉综合征患者冠状动脉病变严重程度与冠心病危险因素之间的相关性。结果:冠脉病变重度组2型糖尿病、吸烟、血脂(TC、TG、LDL-C、ApoB)、肌酐水平升高患者比例较轻度组明显升高(P0.05),血脂(TC、LDL-C、ApoB)、肌酐水平升高患者比例显著高于中度组(P0.05)。多元非条件Logistic回归分析显示:吸烟、肌酐水平与冠脉病变程度相关(P=0.033/P0.01),OR(95%CI)分别为4.553(0.087-2.046),15.991(0.042-0.123)。冠脉病变程度与年龄、高血压、性别、人类SLCO1B1和ApoE基因检测(他汀)检测结果、既往支架至本次发病时间无关。结论:2型糖尿病、吸烟、血脂、肌酐水平与既往支架术后患者再次发生急性冠脉综合征患者的冠脉病变严重程度有关,其中吸烟、肌酐水平是支架术后再次发生急性冠脉综合征患者冠状动脉病变严重程度的独立风险因素。     

贵州从江侗族威宁彝族、荔波瑶族谷胱甘肽S-转移酶M l、Tl 和Pl 的基因多态性研究

目的：研究贵州从江侗族、威宁彝族、荔波瑶族的GSTs基因多态性。方法：在隔离自然人群中,采用多重等住基因特异聚合酶链反应方法分析GSTM1和GSTT1基因多态性,同时采用PCR-RFLP的方法和TaqMan-MGB探针基因分型方法分析GSTP1（A1578G）基因多态性。结果：贵州从江侗族、成宁彝族、荔波瑶族的GSTM1和GSTT1纯合缺失基因型频率分别为59．6％～71．2％、39．4％～72.5％。其GSTP1（A1578G）基因型频率分别为：野生型（AA）为63.3％～75％、杂合子（AG）为23.2％～35．8％、纯合突变型（GG）为0～1.9％。等位基因频率：A为81．2％～86．6％,G为13．4％～18.8％。结论：贵州从江侗族、威宁彝族、荔波瑶族的GSTM1纯合缺失基因型频率在民族间差异无统计学意义,GSTP1（A1578G）基因型频率和等住基因频率在民族间差异无统计学意义,且其等位基因频率均符合Hardy-Weinberg平衡,但其GSTT1纯合缺失基因型频率在民族间差异有统计学意义（P〈0．05）。     

Relationship between DNA damage, total antioxidant capacity and coronary artery disease

OBJECTIVE: It has been known that there was a relation between the levels of DNA damage and the severity of the coronary artery disease (CAD). However, little is known about association of DNA damage with total antioxidant capacity (TAC) and CAD. The aim of this study is to evaluate the relationship between DNA damage, TAC and CAD. METHODS: We used the comet assay to measure DNA damage from 53 patients with angiographically documented CAD and 42 patients with angiographically documented normal coronary vessel. The extent and severity of CAD was calculated to Gensini score index. TAC of plasma was determined using a novel automated measurement method. RESULTS: Mean values of DNA damage were significantly higher in CAD patients than in the control group (p<0.001). There was a positive correlation between Gensini score index and DNA damage (r=0.590, p<0.001). Additionally, significantly positive correlations between score of DNA damage, and diabetes, smoking, obesity and hyperlipidemia were found (p<0.05). There was also a negative correlation between TAC and DNA damage (r=-0.711, p<0.001). The DNA damage was significantly higher in diabetic, smoker, hyperlipidemic and obese individuals than those without these conditions (p=0.001, p=0.006, p=0.001, p=0.004, respectively). CONCLUSIONS: These data indicate that the level of DNA damage is increased and TAC level is decreased in CAD. DNA damage is correlated with the severity of the CAD, and levels of TAC.     

Relationship between serum high sensitivity C-reactive protein with angiographic severity of coronary artery disease and traditional cardiovascular risk factors

Serum high-sensitivity C-reactive protein (hs-CRP) is predictive of coronary artery disease (CAD). The aim of this study was to examine the possible association of hs-CRP with presence and severity of CAD and traditional CAD risk factors. This case-control study was carried out on 2,346 individuals from September 2011 to May 2013. Of these 1,187 had evidence of coronary disease, and were subject to coronary angiography, and the remainder were healthy controls (n = 1,159). Characteristics were determined using standard laboratory techniques and serum Hs-CRP levels were estimated using enzyme-linked immunosorbent assay (ELISA) kits, and severity of CAD was assessed according to the score of obstruction in coronary artery. Serum hs-CRP levels were higher in those with severe coronary disease, who had stenosis ≥ 50% stenosis of at least one coronary artery (all p < 0.001 vs. individuals in healthy control), and correlated significantly with the score for coronary artery disease (all p < 0.01). After adjustment for conventional risk factors, regression analysis revealed that smoking habits, fasting blood glucose, total cholesterol, high-density lipoprotein, hs-CRP, blood pressure, anxiety, dietary intake of vitamin E, and cholesterol remained as independent determinants for angiographic severity of CAD. The area under the receiving operating characteristic (ROC) curve for serum hs-CRP was 0.869 (CI 95% 0.721–0.872, p < 0.001). The optimal values for the cut-off point was a serum hs-CRP of 2.78 mg/l (sensitivity 80.20%, specificity 85%) to predict severity of CAD. Increased serum hs-CRP levels are significantly associated with angiographic severity of CAD, suggesting its value as a biomarkers for predicting CAD.     

Retinol binding protein 4 levels relate to the presence and severity of coronary artery disease

BackgroundThe previous studies have showed that serum retinol binding protein 4 (RBP4) levels increase in metabolic disorders which are closely associated with cardiovascular diseases (CVD). However, the human studies investigating the role of RBP4 in CVD are conflicted. Therefore, we aimed to evaluate the relationship between RBP4 with the presence and severity of coronary artery disease (CAD) in this study.Methods55 patients with presenting acute coronary syndrome (ACS) and 43 control subjects who had various cardiovascular risk factors with normal coronary artery on coronary angiography were included in this study. The serum RBP4 concentrations were measured using ELISA method, clinically and anatomically score models were used to assess the severity of coronary lesion.ResultsSerum RBP4 levels were significantly higher in patients with ACS compared to the without ACS (68.40 ± 47.94 mg/L vs. 49.46 ± 13.64 mg/L; p = 0.014). RBP4 was correlated with GENSINI and SYNTAX I score (r = 0.286 p = 0.034; r = 0.403 p = 0.002 respectively). However, there was no relationship between RBP4 and GRACE score.ConclusionsThe serum RBP4 levels increase in patients with CAD and its increased levels may be correlated with CAD severity.     

The roles of myeloperoxidase in coronary artery disease and its potential implication in plaque rupture

Atherosclerosis is the main pathophysiological process underlying coronary artery disease (CAD). Acute complications of atherosclerosis, such as myocardial infarction, are caused by the rupture of vulnerable atherosclerotic plaques, which are characterized by thin, highly inflamed, and collagen-poor fibrous caps. Several lines of evidence mechanistically link the heme peroxidase myeloperoxidase (MPO), inflammation as well as acute and chronic manifestations of atherosclerosis. MPO and MPO-derived oxidants have been shown to contribute to the formation of foam cells, endothelial dysfunction and apoptosis, the activation of latent matrix metalloproteinases, and the expression of tissue factor that can promote the development of vulnerable plaque. As such, detection, quantification and imaging of MPO mass and activity have become useful in cardiac risk stratification, both for disease assessment and in the identification of patients at risk of plaque rupture. This review summarizes the current knowledge about the role of MPO in CAD with a focus on its possible roles in plaque rupture and recent advances to quantify and image MPO in plasma and atherosclerotic plaques.     

Coronary plaque injury triggers neutrophil activation in patients with coronary artery disease

Activation of leukocytes, in particular polymorphonuclear neutrophils (PMN), is considered an early event in unstable coronary disease. Upon activation PMN liberate myeloperoxidase (MPO), an enzyme which binds to the vessel wall and depletes vascular NO bioavailability. Using coronary balloon angioplasty as a trigger to provoke coronary plaque injury, we assessed the time course of neutrophil activation, local and peripheral levels of myeloperoxidase, and systemic vascular NO bioavailability in patients with stable coronary artery disease. Twenty-four patients with stable CAD were enrolled prior to undergoing percutaneous interventions (PCI, n=14) and diagnostic coronary angiography (n=10), respectively. Following angioplasty arterial MPO plasma levels increased (231.5+/-67.6 to 273.8+/-80.4 pg/mg protein; P<0.01) whereas MPO levels in the coronary sinus decreased (240.8+/-74.4 vs 205.4+/-60.1 pg/mg protein; P<0.01) in the absence of elevated serum markers for myocardial necrosis. Following PCI, patients revealed impaired vascular NO bioavailability as reflected by reduced brachial flow-mediated dilation (FMD; 6.25+/-3.03 to 4.90+/-2.70%; P<0.01), whereas FMD increased in the angiography group. Coronary plaque injury provokes rapid activation of PMN in the absence of myocardial necrosis; the coronary circulation emerges as a primary site for deposition of MPO following injury of the coronary vessel wall. Activation of PMN with release of MPO is not only restricted to the target site, but can be assessed systemically and may represent a critical mechanistic link for impaired systemic vascular NO bioavailability in patients suffering unstable coronary disease.     

Pericardial fat amount is an independent risk factor of coronary artery stenosis assessed by multidetector-row computed tomography: the Korean Atherosclerosis Study 2

Pericardial fat surrounding the heart and coronary arteries might aggravate vessel wall inflammation and stimulate the progression of coronary atherosclerosis. However, there has been little comprehensive evaluation of the effects of pericardial fat on coronary artery disease (CAD). We investigated the relationship between pericardial fat volume and the severity of coronary artery stenosis assessed by computed tomography and angiography among patients with suspected CAD. Participants from the cohort of the Korean Atherosclerosis Study 2 (n = 402, mean age of 54 years, 57.0% men) underwent 64-slice multidetector-row computed tomography (MDCT) to assess pericardial fat amount, coronary artery calcium score (CACS), severity of coronary artery stenosis, and plaque characteristics. Patients with atherosclerotic lesion had significantly larger volume of pericardial fat than patients without atherosclerosis (308 ± 96 cm(3) vs. 251 ± 93 cm(3); P < 0.01). In a multivariate regression analysis adjusting for age, gender and BMI, subjects with more pericardial fat had a higher risk for significant (>50%) stenosed coronary vessels (odds ratio (OR) = 1.012; 95% confidence interval (CI) 1.001-1.030; P = 0.017). This association remained after adjusting for hypertension, diabetes, smoking status, and lipid profiles (OR = 1.007; 95% CI 1.001-1.014; P = 0.042). In conclusion, an increased pericardial fat volume was an independent risk factor for stenotic CAD and could be helpful in assessing subclinical CADs.     

肱动脉内皮依赖性舒张功能鉴别左室舒张功能假性正常化的价值

目的:研究冠心病患者左室舒张功能假性正常化与肱动脉内皮依赖性舒张功能的关系。方法:将75例行选择性冠状动脉造影的患者按冠状动脉病变程度分为单/双支病变组和三支病变组两组,选取48例健康志愿者作为对照组。检测左室舒张功能指标二尖瓣口血流频谱E峰、A峰、E/A比值,同时观察休息时肱动脉反应性充血后内径变化率。结果:单/双支病变组(第一组)E峰、E/A比值下降,肱动脉反应性充血后内径变化率低于正常对照组(P<0.05);三支病变组(第二组)E峰、E/A值无明显改变,肱动脉反应性充血后内径变化率明显低于对照组(P<0.01)。结论:肱动脉内皮依赖性舒张功能可作为鉴别冠心病左室舒张功能假性正常的指标。     

Evaluation of functional severity of coronary artery disease and fluid dynamics' influence on hemodynamic parameters: A review

Coronary Artery Disease (CAD) is responsible for most of the deaths in patients with cardiovascular diseases. Diagnostic coronary angiography analysis offers an anatomical knowledge of the severity of the stenosis. The functional or physiological significance is more valuable than the anatomical significance of CAD. Clinicians assess the functional severity of the stenosis by resorting to an invasive measurement of the pressure drop and flow. Hemodynamic parameters, such as pressure wire assessment fractional flow reserve (FFR) or Doppler wire assessment coronary flow reserve (CFR) are well-proven techniques to evaluate the physiological significance of the coronary artery stenosis in the cardiac catheterization laboratory. Between the two techniques mentioned above, the FFR is seen as a very useful index. The presence of guide wire reduces the coronary flow which causes the underestimation of pressure drop across the stenosis which leads to dilemma for the clinicians in the assessment of moderate stenosis. In such condition, the fundamental fluid mechanics is useful in the development of new functional severity parameters such as pressure drop coefficient and lesion flow coefficient. Since the flow takes place in a narrowed artery, the blood behaves as a non-Newtonian fluid. Computational fluid dynamics (CFD) allows a complete coronary flow simulation to study the relationship between the pressure and flow. This paper aims at explaining (i) diagnostic modalities for the evaluation of the CAD and valuable insights regarding FFR in the evaluation of the functional severity of the CAD (ii) the role of fluid dynamics in measuring the severity of CAD.     

Soluble glycoprotein 130 is inversely related to severity of coronary atherosclerosis

Purpose: Recent studies indicate that the effects of interleukin 6 (IL-6) realized via soluble IL-6 receptor (sIL-6R) facilitate the development of various pathological processes. Soluble gp130 (sgp130) is a naturally occurring inhibitor of signal transduction via this pathway. In this study, we assessed the relationship between circulating levels of IL-6, sIL-6R and sgp130 and severity of coronary atherosclerosis in patients with stable coronary artery disease (CAD).

Methods: Plasma levels of IL-6, sIL-6R and sgp130 were measured in patients with atherosclerotic coronary lesions (n?=?128, group 1) and with intact coronary arteries (n?=?48, group 2). The severity of coronary atherosclerosis was evaluated by the number of affected arteries and by Gensini Score index.

Results: Circulating IL-6 levels in group 1 were significantly higher than those in group 2. The levels of sIL-6R did not differ considerably in both the groups. The levels of sgp130 in group 1 were significantly lower than in group 2. A negative correlation has been revealed between sgp130 levels and the number of affected coronary arteries and Gensini Score index.

Conclusions: Serum concentration of sgp130 in patients with stable CAD is inversely related to severity of coronary damage. Low sgp130 level may serve as an additional indicator of coronary atherosclerosis severity.