Embryo donation or embryo adoption? Conceptual and normative issues

A central question in the ethical debate on the practice of relinquishing in vitro fertilization surplus embryos for family building is whether we ought to think of it more in terms of donating these embryos or in terms of having them adopted. Deciding between these two alternatives is more than a matter of mere terminology. It has an impact on normative questions, e.g., on the question of what criteria for parent selection ought to be applied to the recipients of the embryos, and on the moral evaluation of the act of ‘donating’ the embryo or ‘having it adopted’. In this article, I defend the view that we should conceptualize the relinquishment of spare embryos according to the adoption model, not as a donation. Section 2 sketches the outline of the argument by making clear how we may ground a defense of the adoption model in a theory of parental responsibility without implicitly elevating the moral status of the embryo. Section 3 contains a preliminary defense of the adoption model that draws on geneticism as what seems to me the most persuasive theory of parental responsibility. In section 4, I examine three objections to geneticism and either rebut them or, insofar as they are justified, try to accommodate them into my view. In section 5, I point out some features that distinguish embryo adoption from the adoption of (born) children. I contend, however, that these differences are compatible with the adoption model. Section 6 is concerned with the normative ramifications of this view.     

Skin Donors Positive for HBV Core Antibodies – to Bank or Not to Bank? An Overview from a Regional Tissue Bank

A prompt transplantation of skin allografts on patients with severe, large body area burns is a preferred treatment, but depends on a suitable supply of tissue donors. Limiting factors include donors' identification, families consent, and following the standards – exclusion due to assessed transmissible diseases. To increase the current rate of skin donations to our regional skin bank, we reviewed the data of all potential organ donors, identified at Soroka University Medical Center from October 1997 to December 2000 and evaluated the causes for exclusion, especially due to HBV serological profile. 114/168 (67.9%) patients did not meet the indicated standards for organ donation, among which 20/114 patients (17.5%) positive for anti-HBc (anti-HBc⁺). 54/168 persons were declared brain dead, with consents obtained from 21 families. To discuss the intriguing approval of skin from potential donors with anti-HBc⁺ serology, the literature was reviewed, specifically – the reported outcomes of organ transplants from anti-HBc⁺ donors, updates of HBV and skin, available tests, and finally a look for a safe commendable algorithm. The results suggested that HBV might be replicating in the skin, but proven communication of HBV has not been reported following grafting skin from anti-HBc⁺ donors. Unlike other procured organs and tissues, grafted banked skin is a temporary cover, storable up to six years, under appropriate conditions. Hence, banking of skin from anti-HBc⁺ donors might be considered for future grafting of patients with identical serological profiles, presumably immune to a subsequent HBV infection, until a further re-evaluation of the standards. This procedure is anticipated to increase the potential of organ and tissue donations, specifically skin.     

Yin-yang genetics,or the HSD deCODE controversy

This paper examines a number of social, ethical and cultural issues related to the application of biotechnology. The focus of the paper relies on two different cases of governing biotechnology in Portugal, referring to donation of biological material: the act of donation of eggs and sperm; and volunteers for donation of DNA material for the forensic national DNA database. We analyze the discourses on donation of biological material framing them in rhetorical devices of gift, altruism, informed consent and social responsibility. This comes blended with still unclear and emergent regulation and policies of access, retention, preservation and governing of biological material and of donors' identification. The risks are mitigated by narratives of science and technology as social progress and providers of public good and health benefits, as well as by underlining the individual responsibility in this domain and by reinforcing the rhetoric of gene quality, based on socio-cultural and bio-genetic criteria.     

道德责任视角下患者不良就医行为研究: 现象及对策

从道德责任视角分析患者不良就医行为,通过对272位患者就医道德状况的调查,运用因子分析将其不道德就医行为归为6种类型：伤害医方的行为、获利行为、伤害其他患者及公众的行为、对他人无害的违规行为、认知偏差所致行为和讨好医方的行为;然后分析了目前存在的不道德就医行为主要现象,并提出相应对策建议。     

Hemodilution – An Overview of Current Canadian Practices

Background. Transplant teams evaluate potential organ and tissue donors to exclude donation of tissues at risk for disease transmission. Standards dictate that serological tests be performed on every donor to assess the presence of transmissible diseases including: Human Immunodeficiency Virus 1 & 2, Human T Lymphotropic Virus 1 & 2, Hepatitis C, Hepatitis B surface Antigen, Hepatitis B core Antibody and Syphilis. A limitation of serological testing is the risk of false negative results due to the dilution of the serum. Hemodilution results from the transfusion of fluids (blood products, colloids and/or crystalloid). Confidence in the accuracy and sensitivity of donor serology testing is of utmost importance to ensure the provision of safe organs and tissues for transplantation. Methods. In order to determine the preferred and validated methodology for determining hemodilution, if any; and to determine the level of hemodilution that jeopardizes serologic test results, we reviewed the literature and current testing practices. Tissue banks throughout Canada as well as accrediting bodies were contacted regarding the hemodilution algorithm they utilize. Results. In the absence of a pretransfusion sample, hemodilution calculations are the prevalent methodology for assessing sensitivity of serology testing. A literature search and personal communications provided no documentation on the validation of any hemodilution algorithm or evidence that 50% hemodilution is an acceptable level for accurate serology testing. Conclusion. A validation of hemodilution algorithms and the acceptable or unacceptable rate of hemodilution is required. The utilization of a validated algorithm should be mandated in standards to ensure continuity of practice by all transplantation centres. If validation cannot be obtained, alternative methodologies for serology testing should be investigated.     

电磁场曝露对生物组织电磁特性的影响

电磁辐射严重影响着人体的健康.电磁场生物效应的发生机制与电磁场本身的特性相关,同时也与生物组织在电磁场作用下电磁特性的改变密切相关.生物体内的信号分子、自由基以及磁颗粒等处于外加电磁场中时其电磁特性会发生变化,尤其是不同频率电磁场曝露作用下生物组织的导电、介电以及磁学等特性会有非常显著的区别.明确不同频率电磁场作用下生物组织电磁特性的变化规律是研究电磁场生物效应发生机制以及预防问题的关键.综述了近年来电磁场对于生物组织电磁特性影响的研究成果,并对未来的研究方向做了展望.     

生物组织光热响应及其实验研究

基于激光与生物组织相互作用机理,概述了生物组织的光热响应过程。在此基础上对光热响应所建立的温度场的常用测量技术进行比较,并分别用热电偶和热成像设备进行实验测量。研究结果不仅具有重要的参考价值,对指导临床也有一定的意义。     

高师生物教育专业实验教学现状及改革研究——来自阜阳师范学院生科院毕业生的调查报告

通过对阜阳师范学院生科院生物教育专业毕业生的问卷调查,发现了高师生物教育专业实验教学中存在的问题,并从实验室硬件建设、实验课程体系、实验教学目的、实验教学方式、实验管理体制以及实验教学评价等方面提出了改进思路。     

Seasonal, diurnal and rehydration-induced variation of pressure-volume relationships in Pseudotsuga menziesii

Seasonal and diurnal variation and rehydration effects of pressure-volume parameters in Pseudotsuga menziesii (Mirb.) Franco from a plantation in central Pennsylvania, USA, were evaluated during May-September, 1989. Predawn elastic modulus was lowest in overwintering and newly expanded shoots in May and June, respectively, whereas predawn osmotic potentials at full and zero turgor were lowest in May and in early September, following an August drought. Seasonal variation in predawn relative water content at zero turgor was highly correlated with increases and decreases in elastic modulus and osmotic potential. Diurnal osmotic adjustment resulted in nearly constant turgor pressure, despite decreases in bulk shoot water potential. Elastic modulus decreased diurnally on 1 August and increased on 3 September. Decreases in osmotic potential and/or elastic modulus on 24 June and 1 August lowered the relative water content at zero turgor. Plateaus in pressure-volume data caused by excess apoplastic water, were present in 67% of naturally rehydrated shoots and in all of the shoots artificially rehydrated for 3, 6, 12 and 24 h, and they increased in volume with rehydration time. Plateaus represented 80–95% of the excess apoplastic water lost during pressure-volume analysis. Correcting for plateaus via linear regression had no significant effect on osmotic potential at full turgor; however, uncorrected elastic modulus and relative water content at zero turgor were often significantly lower than the plateau-corrected values, particularly in artificially rehydrated shoots. Plateau-corrected osmotic potential at full turgor and osmotic potential at zero turgor were significantly higher in most artificially rehydrated shoots than in those naturally rehydrated as the result of loss of symplastic solutes. Corrected elastic modulus decreased following 12 and 24 h of rehydration and corrected relative water content at zero turgor increased in as little as 3 h of rehydration. These results indicate that seasonal and diurnal patterns of tissue-water parameters in Pseudotsuga menziesii vary with plant phenology and drought conditions, and that the length of rehydration period is an important consideration for pressure-volume studies.