共查询到20条相似文献,搜索用时 0 毫秒
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Cancer is driven by the somatic evolution of cell lineages that have escaped controls on replication and by the population-level evolution of genes that influence cancer risk. We describe here how recent evolutionary ecological studies have elucidated the roles of predation by the immune system and competition among normal and cancerous cells in the somatic evolution of cancer. Recent analyses of the evolution of cancer at the population level show how rapid changes in human environments have augmented cancer risk, how strong selection has frequently led to increased cancer risk as a byproduct, and how anticancer selection has led to tumor-suppression systems, tissue designs that slow somatic evolution, constraints on morphological evolution and even senescence itself. We discuss how applications of the tools of ecology and evolutionary biology are poised to revolutionize our understanding and treatment of this disease. 相似文献
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Patricia Adair Gowaty 《Human nature (Hawthorne, N.Y.)》1992,3(3):217-249
Evolutionary biology and feminism share a variety of philosophical and practical concerns. I have tried to describe how a
perspective from both evolutionary biology and feminism can accelerate the achievement of goals for both feminists and evolutionary
biologists. In an early section of this paper I discuss the importance of variation to the disciplines of evolutionary biology
and feminism. In the section entitled “Control of Female Reproduction” I demonstrate how insight provided by participation
in life as woman and also as a feminist suggests testable hypotheses about the evolution of social behavior—hypotheses that
are applicable to our investigations of the evolution of social behavior in nonhuman animals. In the section on “Deceit, Self-deception,
and Patriarchal Reversals” I have overtly conceded that evolutionary biology, a scientific discipline, also represents a human
cultural practice that, like other human cultural practices, may in parts and at times be characterized by deceit and self-deception.
In the section on “Femininity” I have indicated how questions cast and answered and hypotheses tested from an evolutionary
perspective can serve women and men struggling with sexist oppression.
Patricia Adair Gowaty studies the evolution of social behavior, particularly mating systems and sex allocation, primarily
in birds. She is most well-known for her long-term studies of eastern bluebirds, which began in 1977 and are on-going. She
was an undergraduate at H. Sophie Newcomb College of Tulane University (1963–1967). In the late sixties and early seventies,
while employed at the Bronx Zoo (New York Zoological Society), she belonged to a feminist “consciousness-raising” group. She
started graduate school in 1974 at the University of Georgia and received her Ph.D. from Clemson University (1980). She had
a postdoctoral position at the University of Oklahoma (1982–1983) and a visiting faculty position at Cornell University through
the Visiting Professorships for Women NSF program (1983–1984) before returning to her bluebird study sites at Clemson in 1985.
She has supported herself and her research efforts throughout her academic career on a series of awards and grants. She is
currently (1990–1995) supported by a Research Scientist Development Award from The National Institute of Mental Health. 相似文献
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Doolittle RF 《Current opinion in structural biology》2005,15(3):248-253
A decade of access to whole-genome sequences has been increasingly revealing about the informational network relating all living organisms. Although at one point there was concern that extensive horizontal gene transfer might hopelessly muddle phylogenies, it has not proved a severe hindrance. The melding of sequence and structural information is being used to great advantage, and the prospect exists that some of the earliest aspects of life on Earth can be reconstructed, including the invention of biosynthetic and metabolic pathways. Still, some fundamental phylogenetic problems remain, including determining the root--if there is one--of the historical relationship between Archaea, Bacteria and Eukarya. 相似文献
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《Current biology : CB》2001,11(16):R631-R632
A new popular book aims to use an evolutionary approach to help the public understand a common disease that does not behave like many others. Nigel Williams reports. 相似文献
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NH Patel 《Development (Cambridge, England)》2012,139(15):2637-2638
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Evolutionary biology: sterile saviours 总被引:1,自引:0,他引:1
Chapman T 《Current biology : CB》2008,18(6):R261-R263
Sterile sperm castes are widespread, but their significance remains enigmatic. New experiments on Drosophila pseudoobscura reveal that sterile sperm may promote the survival of fertilising sperm inside the spermicidal female reproductive tract. 相似文献
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Reciprocal questions often frame studies of the evolution of developmental mechanisms. How can species share similar developmental genetic toolkits but still generate diverse life forms? Conversely, how can similar forms develop from different toolkits? Genomics bridges the gap between evolutionary and developmental biology, and can help answer these evo-devo questions in several ways. First, it informs us about historical relationships, thus orienting the direction of evolutionary diversification. Second, genomics lists all toolkit components, thereby revealing contraction and expansion of the genome and suggesting mechanisms for evolution of both developmental functions and genome architecture. Finally, comparative genomics helps us to identify conserved non-coding elements and their relationship to genome architecture and development. 相似文献
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ANDREW BOURKE 《Journal of Zoology》1989,217(3):522-523
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Davidson EH 《Developmental biology》2011,(1):35-40
At present several entirely different explanatory approaches compete to illuminate the mechanisms by which animal body plans have evolved. Their respective relevance is briefly considered here in the light of modern knowledge of genomes and the regulatory processes by which development is controlled. Just as development is a system property of the regulatory genome, causal explanation of evolutionary change in developmental process must be considered at a system level. Here I enumerate some mechanistic consequences that follow from the conclusion that evolution of the body plan has occurred by alteration of the structure of developmental gene regulatory networks. The hierarchy and multiple additional design features of these networks act to produce Boolean regulatory state specification functions at upstream phases of development of the body plan. These are created by the logic outputs of network subcircuits, and in modern animals these outputs are impervious to continuous adaptive variation unlike genes operating more peripherally in the network. 相似文献
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di Renzo Morchio 《Theoretical biology forum》2004,97(1):16-19
Some time ago I proposed in an Editorial in this journal some considerations on the language of biology. I concluded that, to realize an autonomy of such a language (and therefore of biology), we have to develop a valid language for biology. In such a context, it seemed to me that the term "metaphors" referred to the concepts concerning the information carried by genetic code, was a reasonable one. However, Barbieri's article in this issue of Rivista di Biologia / Biology Forum calls for a reply. Of course, we do not know very much in this field, even if we have some evidence that a sequence of bases on a DNA is not determined only by chance. In any case we can exclude that nature in this occasion has "invented" a code. Nature doesn't "invent" anything: it only follows its rules, that we name "laws of nature". Barbieri quotes the Morse code, but forgets to say that such a code is "conventional" in the sense that it is valid only because it is the result of an "agreement" between Morse and the users of that code. There is nothing more unnatural than a "code": with whom nature should actually have to "reach an agreement"? As a matter of fact, we interpret as "information" what happens by law of nature. Also Barbieri's thesis that genes and proteins are molecular artifacts, assembled by external agents, whereas generally molecules are determined by their bonds, i.e. by internal factors, is a disputable one. It is examined how much an external structure plays a role in ordinary chemical reactions. The "information" of physics is not a semantic information. For such information we can refer to history of literature, telegraphic offices, genetics or biochemistry. 相似文献
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The phylogenetic position of amphioxus, together with its relatively simple and evolutionarily conserved morphology and genome structure, has led to its use as a model for studies of vertebrate evolution. In particular, the recent development of technical approaches, as well as access to the complete amphioxus genome sequence, has provided the community with tools with which to study the invertebrate-chordate to vertebrate transition. Here, we present this animal model, discussing its life cycle, the model species studied and the experimental techniques that it is amenable to. We also summarize the major findings made using amphioxus that have informed us about the evolution of vertebrate traits. 相似文献
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Novel perspectives emerge from a recent conference on the origins of eukaryotic cells, which covered phylogenetics, population genetics and evolutionary consequences of energy requirements and host–pathogen interactions. 相似文献
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DE Ferrier 《Development (Cambridge, England)》2012,139(15):2643-2653
Annelids (the segmented worms) have a long history in studies of animal developmental biology, particularly with regards to their cleavage patterns during early development and their neurobiology. With the relatively recent reorganisation of the phylogeny of the animal kingdom, and the distinction of the super-phyla Ecdysozoa and Lophotrochozoa, an extra stimulus for studying this phylum has arisen. As one of the major phyla within Lophotrochozoa, Annelida are playing an important role in deducing the developmental biology of the last common ancestor of the protostomes and deuterostomes, an animal from which >98% of all described animal species evolved. 相似文献
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Epidemic disease caused by Neisseria meningitidis, the meningococcus, has been recognized for two centuries, but remains incompletely controlled and understood. There have been dramatic reductions in serogroup A and C meningococcal disease following the introduction of protein-polysaccharide conjugate vaccines, but there is currently no comprehensive vaccine against serogroup B meningococci. Genetic analyses of meningococcal populations have provided many insights into the biology, evolution and pathogenesis of this important pathogen. The meningococcus, and its close relative the gonococcus, are the only pathogenic members of the genus Neisseria, and the invasive propensity of meningococci varies widely, with approximately a dozen 'hyperinvasive lineages' responsible for most disease. Despite this, attempts to identify a 'pathogenome', a subset of genes associated with the invasive phenotypes, have failed; however, genome-wide studies of representative meningococcal isolates using high-throughput sequencing are beginning to provide details on the relationship of invasive phenotype and genotype in this fascinating organism and how this relationship has evolved. 相似文献
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A recent study has found that differences in a male trait, considered a textbook example of sexual selection, are in fact due to naturally selected variation in the aerodynamic optimum for each individual. 相似文献