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Regulation of HIV-1 latency by T-cell activation 总被引:1,自引:0,他引:1
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Blazkova J Murray D Justement JS Funk EK Nelson AK Moir S Chun TW Fauci AS 《Journal of virology》2012,86(9):5390-5392
Maintenance of HIV latency in vitro has been linked to methylation of HIV DNA. However, examinations of the degree of methylation of HIV DNA in the latently infected, resting CD4(+) T cells of infected individuals receiving antiretroviral therapy have been limited. Here, we show that methylation of the HIV 5' long terminal repeat (LTR) in the latent viral reservoir of HIV-infected aviremic individuals receiving therapy is rare, suggesting that other mechanisms are likely involved in the persistence of viral latency. 相似文献
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