共查询到20条相似文献,搜索用时 0 毫秒
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Role of the telencephalon in regulating the electrical activity of skeletal muscles in chick embryos
V V Butukhanov 《Zhurnal evoliutsionno? biokhimii i fiziologii》1977,13(6):700-705
On 18-day chick embryos, studies have been made of functional properties of hyperstriatum accesorium (HA) of the telencephalon and that of neck muscles. To investigate the relationship between the HA structure and the EMG in muscles, the former was subjected to unilateral coagulation. Specific levels were established of the energy of oscilatory processes--EEG in the HA and EMG of neck muscles--as well as the relationship between them and possible role of HA structure in regulation of fast movements. 相似文献
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J Sedlácek 《Physiologia Bohemoslovaca》1989,38(1):93-96
The author studied the development of the interaction of GABA and oxazepam on embryonic spontaneous motility in chick embryos during the second half of incubation. In 13-day-old embryos the two substances already potentiated each other's action, despite the fact that GABA, by itself, did not yet have an inhibitory effect. In older embryos this potentiation increased until spontaneous motor activity was almost completely depressed. 相似文献
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J Sedlácek 《Physiologia Bohemoslovaca》1977,26(4):311-314
The effect of the systemic administration of picrotoxin (1 mg/kg egg weight) and GABA (103 mg/kg e.w.) on the spontaneous motility of 11- to 21-day check embryos was studied intact eggs. Embryonal motility was recorded by the method of Kovach (1970). The activating effect of picrotoxin on 11- and 13-day embryos was unaffected by the administration of GABA. In 13- and 17-day-old embryos, GABA did not modify the paroxysmal effect of picrotoxin, but when the two substances were administered together, it prolonged the interparoxysmal intervals. The effect of GABA was most pronounced in 19- and 21-day-old embryos, in which it either stopped picrotoxin paroxysms from developing at all, or noticeably altered the length of the paroxysms, the amplitude of the movements and the length of the interparoxysmal intervals. The results show that the sensitivity of central apparatuses of embryonal spontaneous motility to GABA develops later than the early activatory effect of picrotoxin and are evidence of specific antagonism of these two neutrotropic substances. 相似文献
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Chick embryos were treated with 4-aminopyridine (4 X 100 micrograms) during a critical stage of muscle development, and the effect of enhanced neuromuscular activity upon energy metabolism was studied in two fast-twitch muscles and a slow-tonic muscle. In the slow-tonic muscles of treated embryos, the specific activities of creatine kinase (CK) and lactate dehydrogenase (LDH) were reduced by 11 and 21%, respectively, compared with control values, whereas the ratios of the CK-MB isoforms and the LDH-H subunits increased to 125 and 135% of the control values, respectively. No significant changes could be shown in the enzymatic pattern of fast muscles. These results indicate that a moderate increase in neuromuscular activity of the chick embryo primarily influences the metabolism of developing slow muscles, promoting the development of an enzyme profile characteristic of slow oxidative fibres. 相似文献
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Cross sections of normal and dystrophic digastric, masseter and temporalis muscles from 7-week-old mice were studied by histomorphological and histomorphometrical methods in the light microscope. The histomorphological part of the study revealed marked differences in morphology between normal and dystrophic muscles. Mutual differences between the dystrophic muscles were also observed. Comparisons of the parameters chosen for the histomorphometrical part of the study, i.e., cell size and number of centrally positioned nuclei in a given number of fibers, revealed that the digastric muscle seems to be the least affected and the masseter muscle the most affected by the disease. 相似文献
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Differentiation of myosin in chick embryos 总被引:14,自引:0,他引:14
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Effects of erythropoietin in chick embryos 总被引:2,自引:0,他引:2
P Malpoix 《Biochimica et biophysica acta》1967,145(1):181-184
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Minetti GC Colussi C Adami R Serra C Mozzetta C Parente V Fortuni S Straino S Sampaolesi M Di Padova M Illi B Gallinari P Steinkühler C Capogrossi MC Sartorelli V Bottinelli R Gaetano C Puri PL 《Nature medicine》2006,12(10):1147-1150
Pharmacological interventions that increase myofiber size counter the functional decline of dystrophic muscles. We show that deacetylase inhibitors increase the size of myofibers in dystrophin-deficient (MDX) and alpha-sarcoglycan (alpha-SG)-deficient mice by inducing the expression of the myostatin antagonist follistatin in satellite cells. Deacetylase inhibitor treatment conferred on dystrophic muscles resistance to contraction-coupled degeneration and alleviated both morphological and functional consequences of the primary genetic defect. These results provide a rationale for using deacetylase inhibitors in the pharmacological therapy of muscular dystrophies. 相似文献
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Effects of hyperoxia on chick embryos injected with trypan blue 总被引:1,自引:0,他引:1