WHICH BENEFITS OF RESEARCH PARTICIPATION COUNT AS ‘DIRECT’?

It is widely held that individuals who are unable to provide informed consent should be enrolled in clinical research only when the risks are low, or the research offers them the prospect of direct benefit. There is now a rich literature on when the risks of clinical research are low enough to enroll individuals who cannot consent. Much less attention has focused on which benefits of research participation count as ‘direct’, and the few existing accounts disagree over how this crucial concept should be defined. This disagreement raises concern over whether those who cannot consent, including children and adults with severe dementia, are being adequately protected. The present paper attempts to address this concern by considering first what additional protections are needed for these vulnerable individuals. This analysis suggests that the extant definitions of direct benefits either provide insufficient protection for research subjects or pose excessive obstacles to appropriate research. This analysis also points to a modified definition of direct benefits with the potential to avoid these two extremes, protecting individuals who cannot consent without blocking appropriate research.     

Comment on „designing EMF experiments: What is required to characterize ‘exposure’?”︁

Dr. Peter Valberg has written an excellent and clear paper describing our current understanding of the many facets of characterizing exposure to extremely-low-frequency (ELF) electric and magnetic fields. Dr. Valberg has directed his paper to the characterization of exposures used in laboratory experimentation. In this context, it seems to me that Valberg's program of exposure characterization can be accomplished with currently available instrumentation and with relatively modest effort. Thus, I have no fundamental problems with his recommendations and, really, have only a few minor comments to make. However, if one argues that Valberg's recommendations should be extended to the characterization of exposure in epidemio-logical research, I have serious reservations, which I will mention briefly at the end of this commentary. © 1995 Wiley-Liss, Inc.     

A ‘kinship anthropology of politics’? Interest,the collective self,and kinship in Argentine unions★

In this article I argue for a kinship anthropology of politics, understood as a focus on the day‐to‐day imbrications of kinship and politics in a given political space, and the implications of that for the construction of political subjects. I describe kinship within shop‐floor‐level trade union delegations of state employees in Argentina in three different ways: first, languages of kinship mobilized to describe political allegiance and dispositions, especially inheritance; second, family connections in recruitment and activism; and, third, practices of kinning as relatedness. The combination of these three kinship modes creates the union as kin group, and enables it to act on the world politically in order to transform it.     

WHAT ‘EMPIRICAL TURN IN BIOETHICS’?

Uncertainty as to how we should articulate empirical data and normative reasoning seems to underlie most difficulties regarding the ‘empirical turn’ in bioethics. This article examines three different ways in which we could understand ‘empirical turn’. Using real facts in normative reasoning is trivial and would not represent a ‘turn’. Becoming an empirical discipline through a shift to the social and neurosciences would be a turn away from normative thinking, which we should not take. Conducting empirical research to inform normative reasoning is the usual meaning given to the term ‘empirical turn’. In this sense, however, the turn is incomplete. Bioethics has imported methodological tools from empirical disciplines, but too often it has not imported the standards to which researchers in these disciplines are held. Integrating empirical and normative approaches also represents true added difficulties. Addressing these issues from the standpoint of debates on the fact‐value distinction can cloud very real methodological concerns by displacing the debate to a level of abstraction where they need not be apparent. Ideally, empirical research in bioethics should meet standards for empirical and normative validity similar to those used in the source disciplines for these methods, and articulate these aspects clearly and appropriately. More modestly, criteria to ensure that none of these standards are completely left aside would improve the quality of empirical bioethics research and partly clear the air of critiques addressing its theoretical justification, when its rigour in the particularly difficult context of interdisciplinarity is what should be at stake.     

Quantitative floral phenology at the landscape scale: Is a comparative spatio-temporal description of ‘‘flowering landscapes’’ possible?

Entomophilous flowers form the food resources for insect pollinators. Many pollinator species forage at the landscape scale and depend on floral resources that are highly variable in space and time. We present a general model approach in which the floral resources of plant communities are estimated by the floral phenology and the cover of entomophilous plant species. We applied this landscape model in a case study for three landscape sections (1.5–2.2 km²) with strongly differing land-use patterns. The comparison between a conservation area and two agricultural landscapes shows extreme differences in the quantities and in the course of floral resources.

In a stepwise simplification of the landscape model we tested the effects of input data with lower spatio-temporal resolution. Even if input data for floral phenology and vegetation have a low resolution, the landscape model allows a ranking of landscape-specific floral resource potentials. The results of the case study encourage the use of landscape models to estimate floral resource potentials. The assessment of floral resource potentials may help to define this essential landscape quality for evaluation in practical nature conservation.     

Mitochondria and peroxisomes: Are the ‘Big Brother’ and the ‘Little Sister’ closer than assumed?

Mitochondria and peroxisomes are essential subcellular organelles in mammals. Despite obvious differences, both organelles display certain morphological and functional similarities. Recent studies have elucidated that these highly dynamic and plastic organelles share components of their division machinery. Mitochondria and peroxisomes are metabolically linked organelles, which are cooperating and cross-talking. This review addresses the dynamics and division of mitochondria and peroxisomes as well as their functional similarities to provide insight as to why these organelles share the fission machinery in evolutionary aspects.     

The concepts of ‘plant functional types’ and ‘functional diversity’ in lake phytoplankton – a new understanding of phytoplankton ecology?

1. This is a discussion of the applicability to the phytoplankton of the concepts of ‘plant functional types’ (PFTs) and ‘functional diversity’ (FD), which originated in terrestrial plant ecology. 2. Functional traits driving the performance of phytoplankton species reflect important processes such as growth, sedimentation, grazing losses and nutrient acquisition. 3. This paper presents an objective, mathematical way of assigning PFTs and measuring FD. Ecologists can use this new approach to investigate general hypotheses [e.g. the intermediate disturbance hypothesis (IDH), the insurance hypothesis and synchronicity phenomena] as, for example, in its original formulation the IDH makes its predictions based on FD rather than species diversity.     

Where are the frame-shifted gene ‘duplications’?

Evolution by gene duplication has been well documented, mostly by the discovery of two or more similar amino-acid sequences in proteins translated from one haploid genome. The sequences differ by interpolation and deletion of amino-acids as well as substitution. This is evidence for triplet (codon) addition or subtraction; do deletions/interpolations of one or two nucleotides (frame-shifting mutations) occur? If they are not seen (as in haemoglobins) either this is because they are not generated (the genetic code constrains DNA events); they are generated but edited (gene conversion?); gametes containing them are selected against; or they are actively and rapidly selected against evolutionarily. If they are seen (as in immunoglobulins, possibly) they may generate somatic diversity (as in antibodies) and there may be a limbo of more-or-less changed structural sequences, returning to translation (and selection) only by another frame-shifting event. This suggestion combines neutral mutation theory with pan-selectionism.     

Whatever happened to the ‘microtrabecular concept’?

Keith Porter culminated his stellar career as the founding father of biological electron microscopy by acquiring, in the late 1970s, a high-voltage electron microscope (HVEM). With this magnificent instrument he examined whole-mounts of cultured cells, and perceived within them a structured cytoplasmic matrix he named the \"microtrabecular lattice\". Over the next decade Porter published a series of studies, together with a team of outstanding young colleagues, which elaborated his broader \"microtrabecular concept.\" This concept posited that microtrabeculae were real physical entities that represented the fundamental organization the cytoplasm, and that they were the physical basis of cytoplasmic motility and of cell-shape determination. The present review presents Porter's original images of microtrabeculae, after conversion to a more interpretable \"digital-anaglyph\" form, and discusses the rise and fall of the microtrabecular concept. Further, it explains how the HVEM images of microtrabeculae finally came to be considered as an artifact of the preparative methods Porter used to prepare whole cells for HVEM. Still, Keith's \"microtrabecular concept\" foretold of our current appreciation of the complexity and pervasiveness of the cytoskeleton, which has now been found by more modern methods of EM to actually be the fundamental organizing principle of the cytoplasmic matrix. During the impending eclipse of Porter's microtrabecular concept in the late 1980s, many of Keith's colleagues fondly described the cell as being filled, not with protoplasm, but with \"Porterplasm.\" Despite the fact that Keith's view was clouded by the methods of his time, it would be fitting and apt to retain this name, still today, for the ordered matrix of cytoskeletal macromolecules that exists in the living cell. In the end, the story of what happened to Porter's microtrabecular concept should be an object lesson in scientific hubris that should humble and inform all of us in cell biology, even today--particularly when we begin to think that our most recent methods and observations are achieving \"the last word\".