共查询到20条相似文献,搜索用时 31 毫秒
1.
Karin Hayashi Mariko Makino Masahiro Hashizume Koichi Nakano Koji Tsuboi 《BioPsychoSocial medicine》2010,4(1):9
Background
Since the 1980s, a high EEG abnormality rate has been reported for patients with panic disorder. However, how the EEG abnormalities of panic disorder patients are related to the clinical features and pathology of these patients has yet to be clarified. In this study we investigated whether or not EEG abnormalities are related to the 13 symptoms in the DSM-IV criteria for a diagnosis of panic attacks. 相似文献2.
Miguel A Ramírez Eva Pericuesta Raul Fernandez-Gonzalez Pedro Moreira Belen Pintado Alfonso Gutierrez-Adan 《Reproductive biology and endocrinology : RB&E》2006,4(1):55-12
Background
In the mouse, culture of embryonic stem (ES) cells may decrease their pluripotency and give rise to foetal abnormalities in recipient embryos. These abnormalities are frequently associated with both, chromosome abnormalities or epigenetic alteration of imprinting genes; however, little is known about the epigenetic stability of endogenous retrotransposable elements (REs). In our laboratory, we came across a R1 ES cell line, which at passage 27, lost the ability of germline transmission and started inducing the kinky tail phenotype in all chimeric animals produced with it. 相似文献3.
P. Viau P. FrankenB. Padovani P.-M. Koulibaly J. BenolielM. Razzouk J. Darcourt 《Médecine Nucléaire》2011,35(3):117-125
Purpose
V/P-SPECT lung scan can be combined with computerized tomography (CT) from hybrid camera. We investigated if CT data could be use only with perfusion scans for the diagnosis of acute pulmonary embolism (PE).Patients and methods
In a retrospective study, 75 consecutives patients, referred for suspicion of PE, underwent SPECT ventilation and perfusion scans coupled with a CT on Symbia T2. The perfusion images (P-SPECT) were classified as normal or abnormal with systematized (segmental and sub-segmental) or not systematized perfusion abnormalities. The ventilation images (V-SPECT) were considered as normal or abnormal in light of perfusion defects. The same was done for CT images. Correlations between V-SPECT and CT were studied.Results
Hence, 28 patients had a normal P-SPECT and did not have PE. Patients (47) had an abnormal P-SPECT (among them, 16 turned out to have PE and 31 did not). There were 192 perfusion abnormalities of which 81 were segmental and 81 sub-segmental. Corresponding to these abnormalities, V-SPECT and CT were concordant in 83 % of the cases. When not-concordant, V-SPECT abnormalities with normal CT were found in 14 % of the cases and CT abnormalities with normal V-SPECT were found in 3 % of the cases. According to the EANM guidelines for PE diagnosis, sensitivity was 88 % and specificity 93 % with V/P-SPECT and 100 % and 83 % respectively with CT/P-SPECT (p = NS).Conclusion
V/P-SPECT remains slightly more specific for the diagnosis of PE. However, this study demonstrates that CT/P-SPECT obtained with hybrid camera could be used for PE diagnosis with performances similar to V/P-SPECT. If these results would be confirmed on larger populations, this could lead to a significant reduction of scanning time which would improve patient comfort and reduce the camera load. 相似文献4.
Introduction
Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease characterized by various systemic symptoms and multiple organ damage. We clarify biological and functional abnormalities in SLE by comparing the gene expression profiles of SLE patients with those of healthy individuals. 相似文献5.
Background
Proximal chromosome 15q is implicated in neurodevelopmental disorders including Prader-Willi and Angelman syndromes, autistic disorder and developmental abnormalities resulting from chromosomal deletions or duplications. A subset of genes in this region are subject to genomic imprinting, the expression of the gene from only one parental allele. 相似文献6.
Ying J Nie Mo Y Mok Godfrey CF Chan Albert W Chan Ou Jin Sushma Kavikondala Albert KW Lie Chak S Lau 《Arthritis research & therapy》2010,12(3):R91
Introduction
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoreactive T and B cells, which are believed to be secondary to deficient dendritic cells (DCs). However, whether DC abnormalities occur during their development in the bone marrow (BM) or in the periphery is not known. 相似文献7.
Shin-Hua Lu Josephine W Wu Hsuan-Liang Liu Jian-Hua Zhao Kung-Tien Liu Chih-Kuang Chuang Hsin-Yi Lin Wei-Bor Tsai Yih Ho 《Journal of biomedical science》2011,18(1):8
Background
Alzheimer's disease (AD) is the most common cause of dementia characterized by progressive cognitive impairment in the elderly people. The most dramatic abnormalities are those of the cholinergic system. Acetylcholinesterase (AChE) plays a key role in the regulation of the cholinergic system, and hence, inhibition of AChE has emerged as one of the most promising strategies for the treatment of AD. 相似文献8.
Fumiko Shinkai-Ouchi Yoshio Yamakawa Hideyuki Hara Minoru Tobiume Masahiro Nishijima Kentaro Hanada Ken'ichi Hagiwara 《Proteome science》2010,8(1):53
Background
Prion diseases are fatal neurodegenerative disorders that accompany an accumulation of the disease-associated form(s) of prion protein (PrPSc) in the central nervous system. The neuropathological changes in the brain begin with focal deposits of PrPSc, followed by pathomorphological abnormalities of axon terminal degeneration, synaptic loss, atrophy of dendritic trees, and eventual neuronal cell death in the lesions. However, the underlying molecular basis for these neuropathogenic abnormalities is not fully understood. 相似文献9.
Dimitrios A Pappas Jon T Giles Geoffrey Connors Noah Lechtzin Joan M Bathon Sonye K Danoff 《Arthritis research & therapy》2010,12(3):R104
Introduction
Lung involvement is a common extra-articular manifestation of rheumatoid arthritis (RA) that confers significant morbidity and mortality. The objective of the present study is to assess which respiratory symptoms and patient and disease characteristics are most highly associated with pulmonary function test (PFT) abnormalities in an RA patient cohort without clinical cardiovascular disease. 相似文献10.
Matthias Majer James F Jones Elizabeth R Unger Laura Solomon Youngblood Michael J Decker Brian Gurbaxani Christine Heim William C Reeves 《BMC neurology》2007,7(1):40
Background
Complaints of unrefreshing sleep are a prominent component of chronic fatigue syndrome (CFS); yet, polysomnographic studies have not consistently documented sleep abnormalities in CFS patients. We conducted this study to determine whether alterations in objective sleep characteristics are associated with subjective measures of poor sleep quality in persons with CFS. 相似文献11.
Jan Berend Deijen Diederick Stoffers Henk W Berendse Erik Ch Wolters Jan Theeuwes 《BMC neurology》2006,6(1):43
Background
One of the perceptual abnormalities observed in Parkinson's disease (PD) is a deficit in the suppression of reflexive saccades that are automatically triggered by the onset of a peripheral target. Impairment of substantia nigra function is thought to lead to this reduced ability to suppress reflexive saccades. 相似文献12.
T.L. Buhr A.A. Young Z.A. Minter C.M. Wells D.C. McPherson C.L. Hooban C.A. Johnson E.J. Prokop J.R. Crigler 《Journal of applied microbiology》2012,113(5):1037-1051
Aims
To develop test methods and evaluate the survival of Bacillus anthracis ?Sterne and Bacillus thuringiensis Al Hakam spores after exposure to hot, humid air.Methods and Results
Spores (>7 logs) of both strains were dried on six different test materials. Response surface methodology was employed to identify the limits of spore survival at optimal test combinations of temperature (60, 68, 77°C), relative humidity (60, 75, 90%) and time (1, 4, 7 days). No spores survived the harshest test run (77°C, 90% r.h., 7 days), while > 6·5 logs of spores survived the mildest test run (60°C, 60% r.h., 1 day). Spores of both strains inoculated on nylon webbing and polypropylene had greater survival rates at 68°C, 75% r.h., 4 days than spores on other materials. Electron microscopy showed no obvious physical damage to spores using hot, humid air, which contrasted with pH‐adjusted bleach decontamination.Conclusions
Test methods were developed to show that hot, humid air effectively inactivates B. anthracis ?Sterne and B. thuringiensis Al Hakam spores with similar kinetics.Significance and Impact of the Study
Hot, humid air is a potential alternative to conventional chemical decontamination. 相似文献13.
Background
Perineuriomas have been defined as tumorous lesions of the peripheral nerves which derive from perineurial cell proliferation and may be associated with abnormalities on chromosome 22. 相似文献14.
15.
Background
The clinical and radiological aspects of hypoxic brain injury without ischemia are not well characterized. A spectrum of clinical manifestations have been observed in patients that recover from hypoxic brain injury, including a subset that demonstrate persistent motor system disturbances. Early Magnetic Resonance Imaging (MRI) studies have shown abnormalities in basal ganglia, cerebral and cerebellar cortex. 相似文献16.
Nicolas Fayed Javier Garcia-Campayo Rosa Magallón Helena Andrés-Bergareche Juan V Luciano Eva Andres Julián Beltrán 《Arthritis research & therapy》2010,12(4):R134-12
Introduction
The purpose of this study was to investigate whether single-voxel (SV) proton magnetic resonance spectroscopy (MRS), diffusion-weighted imaging (DWI), and diffusion tensor imaging (DTI) detected differences between fibromyalgia (FM) patients and healthy controls. We also searched for correlations between neuroimaging abnormalities and neuropsychological variables. 相似文献17.
Jia Huang Renmin Ni Xiaoli Chen Lili Huang Yaqin Mo Dongzi Yang 《Reproductive biology and endocrinology : RB&E》2010,8(1):142
Background
Adults with polycystic ovary syndrome (PCOS) can have multiple metabolic abnormalities. However, studies in the adolescent population are still limited and these results seem to vary widely. This study was to investigate the metabolic abnormalities in adolescents with PCOS in South China and the potential risk factors contributed to these health risks. 相似文献18.
Carlo Paribello Leeping Tao Anthony Folino Elizabeth Berry-Kravis Michael Tranfaglia Iryna M Ethell Douglas W Ethell 《BMC neurology》2010,10(1):91
Background
Fragile X syndrome (FXS) is a disorder characterized by a variety of disabilities, including cognitive deficits, attention-deficit/hyperactivity disorder, autism, and other socio-emotional problems. It is hypothesized that the absence of the fragile X mental retardation protein (FMRP) leads to higher levels of matrix metallo-proteinase-9 activity (MMP-9) in the brain. Minocycline inhibits MMP-9 activity, and alleviates behavioural and synapse abnormalities in fmr1 knockout mice, an established model for FXS. This open-label add-on pilot trial was conducted to evaluate safety and efficacy of minocycline in treating behavioural abnormalities that occur in humans with FXS. 相似文献19.
Background
PhiC31 integrase facilitates efficient integration of transgenes into human and mouse genomes and is considered for clinical gene therapy. However recent studies have shown that the enzyme can induce various chromosomal abnormalities in primary human embryonic cells and mammalian cell lines. The mechanisms involved are unknown, but it has been proposed that PhiC31 attachment sites in the host genome recombine leading to chromosomal translocations. 相似文献20.
William C Reeves Christine Heim Elizabeth M Maloney Laura Solomon Youngblood Elizabeth R Unger Michael J Decker James F Jones David B Rye 《BMC neurology》2006,6(1):41-8