共查询到20条相似文献,搜索用时 31 毫秒
1.
Isabelle Fernandes Hélène Chanut-Delalande Pierre Ferrer Yvan Latapie Lucas Waltzer Markus Affolter François Payre Serge Plaza 《Developmental cell》2010,18(1):64-76
Highlights? In Drosophila epidermis, shavenbaby controls ZPD gene expression ? Apical cell shape remodeling relies on the coordinated action of ZPD genes ? ZPD proteins define sub-regions in the apical extracellular matrix (aECM) ? ZPD products maintain localized apical membrane/aECM interactions. 相似文献
2.
Kunimoto K Yamazaki Y Nishida T Shinohara K Ishikawa H Hasegawa T Okanoue T Hamada H Noda T Tamura A Tsukita S Tsukita S 《Cell》2012,148(1-2):189-200
Highlights? Mice expressing truncated Odf2 cough and sneeze due to primary ciliary dyskinesia ? Full-length Odf2 is needed for the formation of basal body-associated basal feet ? In the absence of basal feet, basal bodies fail to align with planar polarity cues ? Polarization of basal bodies by Odf2 is required for coordinated ciliary beating 相似文献
3.
Phillip J. Stansfeld Elizabeth E. Jefferys Mark S.P. Sansom 《Structure (London, England : 1993)》2013,21(5):810-819
Highlights? Multiscale MD simulations predict the interactions of lipids with membrane proteins ? The method is evaluated via comparison with the structure of Aqp0 in a membrane ? Simulations of aquaporins reveal a broadly conserved protein/lipid interface ? The results suggest interchange between annular and bulk lipids 相似文献
4.
Gražvydas Lukinavičius Darja Lavogina Meritxell Orpinell Keitaro Umezawa Luc Reymond Nathalie Garin Pierre Gönczy Kai Johnsson 《Current biology : CB》2013,23(3):265-270
Highlights? Selective chemical crosslinking identifies novel protein-protein interactions ? Superresolution microcopy defines the localization of centrosomal proteins ? Cep57, Cep63, and Cep152 form a ring-like centrosomal complex 相似文献
5.
Xu Liu Tyson R. Shepherd Ann M. Murray Zhen Xu Ernesto J. Fuentes 《Structure (London, England : 1993)》2013,21(3):342-354
Highlights? The Tiam1 PDZ domain preferentially binds a subset of syndecan (SDC) proteins ? The PDZ domain/phospho-SDC1 structure reveals a phosphoryl binding pocket ? Ligand specificity and phosphorylation regulate PDZ/SDC interactions and signaling ? Tiam1 PDZ domain dynamics are ligand-dependent and regulated by phosphorylation 相似文献
6.
Seham Ebrahim Tomoki Fujita Bryan A. Millis Elliott Kozin Xuefei Ma Sachiyo Kawamoto Michelle A. Baird Michael Davidson Shigenobu Yonemura Yasuo Hisa Mary Anne Conti Robert S. Adelstein Hirofumi Sakaguchi Bechara Kachar 《Current biology : CB》2013,23(8):731-736
Highlights? NMII within epithelial junctions assembles into a chain of muscle-like sarcomeres. ? Sarcomeres are paired across the junction to form transcellular contractile units. ? NMII isoforms show differential expression across heterotypic cell junctions. ? Coordinated sarcomere contractility modulates apical cell shape and tissue geometry 相似文献
7.
Barish GD Yu RT Karunasiri MS Becerra D Kim J Tseng TW Tai LJ Leblanc M Diehl C Cerchietti L Miller YI Witztum JL Melnick AM Dent AL Tangirala RK Evans RM 《Cell metabolism》2012,15(4):554-562
Highlights? Bcl6 is a critical antiatherogenic regulator ? Inhibition of Bcl6-SMRT/NCoR interactions induces atherogenic gene expression ? SMRT and NCoR cistromes each exceed 30,000 sites, with a nearly 50% overlap ? Bcl6 recruits SMRT and NCoR to NF-κB-driven inflammatory and tissue remodeling genes 相似文献
8.
Xu Jia Jing Zhang Wenxia Sun Weizhi He Hengyi Jiang Dongrong Chen Alastair I.H. Murchie 《Cell》2013,152(1-2):68-81
Highlights? The 5′ leader RNA of aminoglycoside antibiotic-resistance genes is conserved ? Aminoglycosides induce reporter gene expression by interacting with the leader RNA ? The aminoglycosides bind to the leader RNA and induce a change in the RNA structure ? Induction is independent of leader peptide stalling or drug-ribosome interactions 相似文献
9.
Shan Liu Yinghua Chen Jess Li Tao Huang Sergey Tarasov Aaren King Allan M. Weissman R. Andrew Byrd Ranabir Das 《Structure (London, England : 1993)》2012,20(12):2138-2150
Highlights? The ubiquitin ligase gp78 recruits ubiquitinated substrates via its CUE domain ? gp78CUE:Ub complex reveals a large set of specific interactions ? gp78CUE binds to both distal and proximal moities of diubiquitin in a similar fashion ? The gp78CUE domain binds to K48- and K63-linked diubiquitin equally well 相似文献
10.
Reut Shalgi Jessica A. Hurt Irina Krykbaeva Mikko Taipale Susan Lindquist Christopher B. Burge 《Molecular cell》2013,49(3):439-452
Highlights? Global translation elongation pause at 5′ end of ORFs in severe heat shock ? Modulation of Hsp70 levels/activity affects elongation pausing ? Pausing is associated with hydrophobic N termini ? Hsp70 shows reduced ribosome association and altered interactions in heat stress 相似文献
11.
Highlights? CcmK2 shows a far stronger self-interaction than do other CcmK paralogs ? CcmK2 forms dodecamers via interactions of the αD helix on the concave face ? Hexagonally tiled CcmK2 sheets can weld via this interaction into a double layer ? FRET data supports a double-layered concave-to-concave model of the shell 相似文献
12.
13.
Tuo Deng Christopher J. Lyon Laurie J. Minze Jianxin Lin Jia Zou Joey Z. Liu Yuelan Ren Zheng Yin Dale J. Hamilton Patrick R. Reardon Vadim Sherman Helen Y. Wang Kevin J. Phillips Paul Webb Stephen T.C. Wong Rong-fu Wang Willa A. Hsueh 《Cell metabolism》2013,17(3):411-422
Highlights? Obesity enhances MHCII expression in primary human and mouse adipocytes ? Adipocytes activate CD4+ ARTs via MHCII and leptin to induce adipose inflammation ? Macrophage changes in adipose follow adipocyte and T cell interactions during HFD ? Adaptive immune mechanisms are essential to obesity-induced adipose inflammation 相似文献
14.
Hume Stroud Maxim V.C. Greenberg Suhua Feng Yana V. Bernatavichute Steven E. Jacobsen 《Cell》2013,152(1-2):352-364
Highlights? Genome-wide single-nucleotide resolution methylation maps in 86 silencing mutants ? Complex interplays between different DNA methylation pathways ? Identification of novel regulators of DNA methylation 相似文献
15.
Bjørn Dalhus Line Nilsen Hanne Korvald Joy Huffman Rune Johansen Forstrøm Cynthia T. McMurray Ingrun Alseth John A. Tainer Magnar Bjørås 《Structure (London, England : 1993)》2013,21(1):154-166
Highlights? Unflipped AP site stabilized by helix-hairpin-helix DNA glycosylase homolog Mag2 ? Nonenzymatic AP site recognition and DNA sculpting ? Sculpting of DNA conformation enhances substrate transfer between proteins 相似文献
16.
Daniel J. Bumbarger Metta Riebesell Christian Rödelsperger Ralf J. Sommer 《Cell》2013,152(1-2):109-119
Highlights? Massive neural circuit rewiring between nematodes with divergent feeding behavior ? Striking patterns correlate with known functional differences ? Motor synapse differences indicate a substantial change in information flow ? Correlates of predatory feeding behavior are identified 相似文献
17.
Michele Tinti Lars Kiemer Stefano Costa Martin L. Miller Francesca Sacco Jesper V. Olsen Martina Carducci Serena Paoluzi Francesca Langone Christopher T. Workman Nikolaj Blom Kazuya Machida Christopher M. Thompson Mike Schutkowski Søren Brunak Matthias Mann Bruce J. Mayer Luisa Castagnoli Gianni Cesareni 《Cell reports》2013,3(4):1293-1305
Highlights? The recognition specificity of 70 SH2 domains is probed ? Recognition specificity diverges faster than sequence ? PepspotDB is a database of protein interactions mediated by SH2 domains 相似文献
18.
Myosin-V Opposes Microtubule-Based Cargo Transport and Drives Directional Motility on Cortical Actin
Lukas C. Kapitein Petra van Bergeijk Joanna Lipka Nanda Keijzer Phebe S. Wulf Eugene A. Katrukha Anna Akhmanova Casper C. Hoogenraad 《Current biology : CB》2013,23(9):828-834
Highlights? Myosin-V alternates between active and passive actin-binding modes ? Myosin-V opposes kinesin-propelled cargo redistribution ? Myosin-V anchors kinesin-propelled cargo in actin-rich areas ? Myosin-V can drive medium-range directional transport at the cell periphery 相似文献
19.
Yuval Rinkevich Ayelet Voskoboynik Amalia Rosner Claudette Rabinowitz Guy Paz Matan Oren Jacob Douek Gilad Alfassi Elizabeth Moiseeva Katherine J. Ishizuka Karla J. Palmeri Irving L. Weissman Buki Rinkevich 《Developmental cell》2013,24(1):76-88
Highlights? Identification of a niche for germline and somatic stem cells in a basal chordate ? Stem cells repeatedly migrate between aged or damaged niches into developing niches 相似文献
20.
Bhupinder Pal Toula Bouras Wei Shi François Vaillant Julie M. Sheridan Naiyang Fu Kelsey Breslin Kun Jiang Matthew E. Ritchie Matthew Young Geoffrey J. Lindeman Gordon K. Smyth Jane E. Visvader 《Cell reports》2013,3(2):411-426
Highlights? The mammary epigenome is highly sensitive to steroid hormones at specific developmental stages ? Ezh2 links hormonal cues to changes in chromatin structure and gene expression ? Progesterone is a key in vivo regulator of Ezh2 ? Hormone-induced chromatin changes likely play a role in the initiation of breast cancer 相似文献