共查询到20条相似文献,搜索用时 15 毫秒
1.
Y. Groen A. E. den Heijer A. B. M. Fuermaier M. Althaus O. Tucha 《Attention deficit and hyperactivity disorders》2018,10(2):141-150
Studies in children with ADHD suggest impairments in social cognitive functions, whereas studies in adults with ADHD are scarce and inconclusive. The aim of this study was to investigate the relationship between ADHD traits and self-reported social cognitive style in a sample of adults from the general population. For this purpose, a community sample of 685 adults filled out online self-report questionnaires about ADHD symptoms (ADHD Rating Scale, ARS), social cognitive functioning and friendships. The Empathy Quotient (EQ) with the subscales Cognitive Empathy (CE), Emotional Empathy (EE) and Social Skills (SS), and the Systemizing Quotient (SQ) were included for measuring social cognitive style and the Friendship Questionnaire (FQ) for the quality of friendships. Participants who met the DSM-5 criteria on the ARS (‘subclinical ADHD’; n = 56) were compared regarding their social cognitive functioning scores with a control group (n = 56) that was matched for age, sex and student status. With small effect sizes, the subclinical ADHD group showed reduced EE scores on the EQ and a more male social cognitive profile. This result was not influenced by sex or ADHD subtype. This study points to a relationship between traits of ADHD and the emotional aspect of empathy, whereas more complex aspects of empathy were unrelated. These findings should be corroborated in clinical patients with ADHD, employing neuropsychological tests rather than self-report questionnaires. 相似文献
2.
Baron-Cohen S Richler J Bisarya D Gurunathan N Wheelwright S 《Philosophical transactions of the Royal Society of London. Series B, Biological sciences》2003,358(1430):361-374
Systemizing is the drive to analyse systems or construct systems. A recent model of psychological sex differences suggests that this is a major dimension in which the sexes differ, with males being more drawn to systemize than females. Currently, there are no self-report measures to assess this important dimension. A second major dimension of sex differences is empathizing (the drive to identify mental states and respond to these with an appropriate emotion). Previous studies find females score higher on empathy measures. We report a new self-report questionnaire, the Systemizing Quotient (SQ), for use with adults of normal intelligence. It contains 40 systemizing items and 20 control items. On each systemizing item, a person can score 2, 1 or 0, so the SQ has a maximum score of 80 and a minimum of zero. In Study 1, we measured the SQ of n = 278 adults (114 males, 164 females) from a general population, to test for predicted sex differences (male superiority) in systemizing. All subjects were also given the Empathy Quotient (EQ) to test if previous reports of female superiority would be replicated. In Study 2 we employed the SQ and the EQ with n = 47 adults (33 males, 14 females) with Asperger syndrome (AS) or high-functioning autism (HFA), who are predicted to be either normal or superior at systemizing, but impaired at empathizing. Their scores were compared with n = 47 matched adults from the general population in Study 1. In Study 1, as predicted, normal adult males scored significantly higher than females on the SQ and significantly lower on the EQ. In Study 2, again as predicted, adults with AS/HFA scored significantly higher on the SQ than matched controls, and significantly lower on the EQ than matched controls. The SQ reveals both a sex difference in systemizing in the general population and an unusually strong drive to systemize in AS/HFA. These results are discussed in relation to two linked theories: the 'empathizing-systemizing' (E-S) theory of sex differences and the extreme male brain (EMB) theory of autism. 相似文献
3.
Shirenova Sofie D. Khlebnikova Nadezhda N. Krupina Nataliya A. 《Biochemistry. Biokhimii?a》2021,86(6):704-715
Biochemistry (Moscow) - Early-life stress is a risk factor for the development of behavioral and cognitive disorders in humans and animals. Such stressful situations include social isolation in... 相似文献
4.
Fang Xie Yun Zhao Jing Ma Jing-Bo Gong Shi-Da Wang Liang Zhang Xiu-Jie Gao Ling-Jia Qian 《Cell stress & chaperones》2016,21(5):915-926
Chronic stress is a risk factor in the development of cognitive decline and even Alzheimer’s disease (AD), although its underlying mechanism is not fully understood. Our previous data demonstrated that the level of homocysteine (Hcy) was significantly elevated in the plasma of stressed animals, which suggests the possibility that Hcy is a link between stress and cognitive decline. To test this hypothesis, we compared the cognitive function, plasma concentrations of Hcy, and the brain beta-amyloid (Aβ) level between rats with or without chronic unexpected mild stress (CUMS). A lower performance by rats in behavioral tests indicated that a significant cognitive decline was induced by CUMS. Stress also disturbed the normal processing of Aβ precursor protein (APP) and resulted in the accumulation of Aβ in the brains of rats, which showed a positive correlation with the hyperhomocysteinemia (HHcy) that appeared in stressed rats. Hcy-targeting intervention experiments were used to verify further the involvement of Hcy in stress-induced APP misprocessing and related cognitive decline. The results showed that diet-induced HHcy could mimic the cognitive impairment and APP misprocessing in the same manner as CUMS, while Hcy reduction by means of vitamin B complex supplements and betaine could alleviate the cognitive deficits and dysregulation of Aβ metabolism in CUMS rats. Taken together, the novel evidence from our present study suggests that Hcy is likely to be involved in chronic stress-evoked APP misprocessing and related cognitive deficits. Our results also suggested the possibility of Hcy as a target for therapy and the potential value of vitamin B and betaine intake in the prevention of stress-induced cognitive decline. 相似文献
5.
A self-report questionnaire tapping 98 frequently reported physical stress reactions was subjected to factor analysis. The instrument was given to 1,210 subjects (593 males, 520 females, and 97 who failed to indicate their gender). The final factor solution identified 18 interpretable factors for the combined sample. Some of the more notable findings are: (a) Gastric Distress (Factor 1) is by far the most prominent factor and accounts for .491 of the total variance; (b) the factor solutions for males and females are highly similar, although Cardiorespiratory Activity (Factor 2) is defined by a greater diversity of noncardiac reactions for females than for males; and (c) six independent striated muscle tension factors can be identified for the entire sample. Results are discussed in terms of a behavioral conceptualization of psychosomatic symptoms. Clinical implications are noted. 相似文献
6.
Stereotypies and other abnormal repetitive behaviors: potential impact on validity, reliability, and replicability of scientific outcomes 总被引:1,自引:0,他引:1
Garner JP 《ILAR journal / National Research Council, Institute of Laboratory Animal Resources》2005,46(2):106-117
Normal behavior plays a key role in facilitating homeostasis, especially by allowing the animal to control and modify its environment. Captive environments may interfere with these behavioral responses, and the resulting stress may alter many physiological parameters. Abnormal behaviors indicate that an animal is unable to adjust behaviorally to the captive environment and, hence, may be expressing abnormal physiology. Therefore, captive environments may affect the following aspects of an experiment: validity, by introducing abnormal animals into experiments; reliability, by increasing interindividual variation through the introduction of such individuals; and replicability, by altering the number and type of such individuals between laboratories. Thus, far from increasing variability, enrichment may actually improve validity, reliability, and replicability by reducing the number of abnormal animals introduced into experiments. In this article, the specific example of abnormal repetitive behaviors (ARBs) is explored. ARBs in captive animals appear to involve the same mechanisms as ARBs in human psychiatry, which reflect underlying abnormalities of brain function. ARBs are also correlated with a wide range of behavioral changes that affect experimental outcomes. Thus, ARBs in laboratory animals may compromise validity, reliability, and replicability, especially in behavioral experiments; and enrichments that prevent ARB may enhance validity, reliability, and replicability. Although many links in this argument have been tested experimentally, key issues still remain in the interpretation of these data. In particular, it is currently unclear (1) whether or not the differences in brain function seen in animals performing ARB are abnormal, (2) which common behavioral paradigms are affected by ARB, and (3) whether enrichment does indeed improve the quality of behavioral data. Ongoing and future work addressing these issues is outlined. 相似文献
7.
Dufau S Duñabeitia JA Moret-Tatay C McGonigal A Peeters D Alario FX Balota DA Brysbaert M Carreiras M Ferrand L Ktori M Perea M Rastle K Sasburg O Yap MJ Ziegler JC Grainger J 《PloS one》2011,6(9):e24974
Investigating human cognitive faculties such as language, attention, and memory most often relies on testing small and homogeneous groups of volunteers coming to research facilities where they are asked to participate in behavioral experiments. We show that this limitation and sampling bias can be overcome by using smartphone technology to collect data in cognitive science experiments from thousands of subjects from all over the world. This mass coordinated use of smartphones creates a novel and powerful scientific "instrument" that yields the data necessary to test universal theories of cognition. This increase in power represents a potential revolution in cognitive science. 相似文献
8.
Comorbidity of depression and diabetes is a serious risk factor worsening the complications such as cognitive function and locomotion. Treatment under this condition becomes extremely complicated. Insulin signaling and autophagy pathways are involved in modulation of learning and memory. Rosiglitazone (ROSI) ameliorate cognitive deficit associated with depression and insulin resistance. In the present study, we investigated the effect of ROSI against chronic unpredictable stress (CUS) induced depression as a risk factor for diabetes and behavioral dysfunctions. Adult male Swiss albino mice were exposed to CUS alongside ROSI (5 mg/kg/day) treatment for 21 days. Thereafter, animals were subjected to different behavioral studies to assess depressive like behavior, cognition and locomotion. The effect of ROSI on insulin signaling, autophagy and apoptosis were evaluated in the hippocampus. CUS resulted in depressive like behavior, cognitive impairment and hypolocomotion associated with oxidative stress, impaired glucose tolerance and hypercorticosteronemia. CUS significantly impaired hippocampal insulin signaling, membrane translocation of glucose transporter type 4 (GLUT4) as well as decreased the expression of autophagy5, autophagy7, B-cell lymphoma 2 and apoptosis inhibitory protein 2. ROSI significantly reduced depressive like behavior, postprandial blood glucose, hypercorticosteronemia, oxidative and inflammatory stress, and apoptosis in stressed mice. Moreover, ROSI treatment effectively improved hippocampal insulin signaling, GLUT4 membrane translocation and cognitive performance in depressed mice. ROSI administration might prove to be effective for neurological disorders associated with depressive like behavior and impaired glucose tolerance. 相似文献
9.
This paper reviews the role of the n-3 fatty acids in the regulation of cognitive functions, locomotor and exploratory activity and emotional status in rodents. There are disparate data on the performance of n-3 fatty acid deficient animals in the open field test and elevated plus maze. Results obtained in our laboratory indicated slower habituation to the open field in deficient mice, which affects total locomotor and exploratory parameters. We also observed no change in plus maze performance of deficient mice under low-stress but elevated anxiety under high-stress conditions. There is some evidence of elevated aggression and increased immobility time in the forced swimming test caused by n-3 fatty acid deficiency in rodents. Effects of n-3 fatty acid deficiency and supplementation on learning in several tests such as the Morris water maze, two odor olfactory discriminations, radial arm maze performance and avoidance tasks are reviewed in detail. There is some evidence of an enhanced vulnerability to stress of n-3 fatty acid deficient animals and this factor can influence performance in a variety of tests. Thus, behavioral tasks that involve a higher level of stress may better differentiate behavioral effects related to brain docosahexaenoic acid (DHA) status. It is suggested that a fruitful area for future investigations of functional alterations related to brain DHA status will be the delineation of the factors underlying changes in performance in behavioral tasks. The possible role of non-cognitive factors like emotionality and attention in the impaired performance of n-3 fatty acid deficient animals also requires further investigation. 相似文献
10.
A central hypothesis to account for the ubiquity of rituals across cultures is their supposed anxiolytic effects: rituals being maintained because they reduce existential anxiety and uncertainty. We aimed to test the anxiolytic effects of rituals by investigating two possible underlying mechanisms for it: cognitive load and repetitive movement. In our pre-registered experiment (osf.io/rsu9x), 180 undergraduates took part in either a stress or a control condition and were subsequently assigned to either control, cognitive load, undirected movement, a combination of undirected movement and cognitive load, or a ritualistic intervention. Using both repeated self-report measures and continuous physiological indicators of anxiety, we failed to find direct support for a cognitive suppression effect of anxiety through ritualistic behavior. Nevertheless, we found that induced stress increased participants’ subsequent repetitive behavior, which in turn reduced physiological arousal. This study provides novel evidence for plausible underlying effects of the proposed anxiolytic effect of rituals: repetitive behavior but not cognitive load may decrease physiological stress responses during ritual. 相似文献
11.
Chronic stress produces sex-specific neuromorphological changes in a variety of brain regions, which likely contribute to
the gender differences observed in stress-related illnesses and cognitive ability. Here, we review the literature investigating
the relationship between chronic stress and sex differences on brain plasticity and function, with an emphasis on morphological
changes in dendritic arborization and spines in the hippocampus, prefrontal cortex, and amygdala. These brain structures are
highly interconnected and sensitive to stress and gonadal hormones, and influence a variety of cognitive abilities. Although
much less work has been published using female subjects than with male subjects, the findings suggest that the relationship
between brain morphology and function is very different between the sexes. After reviewing the literature, we present a model
showing how chronic stress influences the morphology of these brain regions and changes the dynamic of how these limbic structures
interact with each other to produce altered behavioral outcomes in spatial ability, behavioral flexibility/executive function,
and emotional arousal. 相似文献
12.
In this study, we assessed the effects of ginsenoside Re (GRe) administration on repeated immobilization stressinduced behavioral alterations using the forced swimming test (FST), the elevated plus maze (EPM), and the active avoidance conditioning test (AAT). Additionally, we examined the effect of GRe on the central adrenergic system by observing changes in neuronal tyrosine hydroxylase (TH) immunoreactivity and brain-derived neurotrophic factor (BDNF) mRNA expression in the rat brain. Male rats received 10, 20, or 50 mg/kg GRe (i.p.) 30 min before daily exposures to repeated immobilization stress (2 h/day) for 10 days. Activation of the hypothalamic-pituitary-adrenal (HPA) axis in response to repeated immobilization was confirmed by measuring serum levels of corticosterone (CORT) and the expression of corticotrophin-releasing factor (CRF) in the hypothalamus. Repeated immobilization stress increased immobility in the FST and reduced openarm exploration in the EPM test. It also increased the probability of escape failures in the AAT test, indicating a reduced avoidance response. Daily administration of GRe during the repeated immobilization stress period significantly inhibited the stress-induced behavioral deficits in these behavioral tests. Administration of GRe also significantly blocked the increase in TH expression in the locus coeruleus (LC) and the decrease in BDNF mRNA expression in the hippocampus. Taken together, these findings indicate that administration of GRe prior to immobilization stress significantly improved helpless behaviors and cognitive impairment, possibly through modulating the central noradrenergic system in rats. These findings suggest that GRe may be a useful agent for treating complex symptoms of depression, anxiety, and cognitive impairment. 相似文献
13.
Background
Early stone tools provide direct evidence of human cognitive and behavioral evolution that is otherwise unavailable. Proper interpretation of these data requires a robust interpretive framework linking archaeological evidence to specific behavioral and cognitive actions.Methodology/Principal Findings
Here we employ a data glove to record manual joint angles in a modern experimental toolmaker (the 4th author) replicating ancient tool forms in order to characterize and compare the manipulative complexity of two major Lower Paleolithic technologies (Oldowan and Acheulean). To this end we used a principled and general measure of behavioral complexity based on the statistics of joint movements.Conclusions/Significance
This allowed us to confirm that previously observed differences in brain activation associated with Oldowan versus Acheulean technologies reflect higher-level behavior organization rather than lower-level differences in manipulative complexity. This conclusion is consistent with a scenario in which the earliest stages of human technological evolution depended on novel perceptual-motor capacities (such as the control of joint stiffness) whereas later developments increasingly relied on enhanced mechanisms for cognitive control. This further suggests possible links between toolmaking and language evolution. 相似文献14.
Research examining the contribution of genetics to behavior is increasingly focused on higher order behavioral and cognitive processes including the ability to modify behaviors when environmental demands change. The frontal cortices of mammals, including rodents, subserve a diverse set of behavioral and cognitive functions including motor planning, social behavior, evaluation of expected outcomes and working memory, which may be particularly sensitive to genetic factors and interactions with experience (e.g. stress). Behavioral flexibility is a core attribute of these functions. This review orients readers to the current landscape of the literature on the frontocortical bases of behavioral flexibility in rodent laboratory experiments. Studies are divided into three broad categories: reversal learning, inhibitory learning and set‐shifting. Functional dissociations within the broader scope of behavioral flexibility are reviewed, followed by discussion of the associations between specific components of frontal cortex and specific aspects of relevant behavioral processes. Finally, the authors identify open questions that need to be addressed to better establish the constituents of frontal cortex underlying behavioral flexibility. 相似文献
15.
Carlyle Mendes Coelho Cristiano Schetini de Azevedo Marcelo Alcino de Barros Vaz Guimarães 《Journal of applied animal welfare science : JAAWS》2016,19(4):353-362
Environmental enrichment is a technique that may reduce the stress of nonhuman animals in captivity. Stress may interfere with normal behavioral expression and affect cognitive decision making. Noninvasive hormonal studies can provide important information about the stress statuses of animals. This study evaluated the effectiveness of different environmental enrichment treatments in the diminution of fecal glucocorticoid metabolites (stress indicators) of three captive maned wolves (Chrysocyon brachyurus). Correlations of the fecal glucocorticoid metabolite levels with expressed behaviors were also determined. Results showed that environmental enrichment reduced fecal glucocorticoid metabolite levels. Furthermore, interspecific and foraging enrichment items were most effective in reducing stress in two of the three wolves. No definite pattern was found between behavioral and physiological responses to stress. In conclusion, these behavioral and physiological data showed that maned wolves responded positively from an animal well being perspective to the enrichment items presented. 相似文献
16.
Stress Inventory-6, a 72-item self-report questionnaire designed to tap 18 factors of physical stress reactions, was subjected to factor analysis. The instrument was given to 474 students (254 females, 206 males, and 14 who failed to indicate their gender). The final factor solution identified 16 first-order and 4 second-order factors. The first-order solution replicated most of the factors identified in a previous study and defined factors in terms of organ system, muscle group, and simple content. In the second-order solution, Factors I, III, and IV include symptoms that are immediate and direct, appear to be related to arousal of the somatic and sympathetic nervous system, and are marked prominently by cardiorespiratory activity. In contrast, Factor II includes symptoms that are indirect and often delayed consequences of sustained arousal (Fatigue and Lack of Energy, Headaches, Backaches, etc.). A major distinction can be made between stress arousal Factors I and III. Factor III appears to be a simple fight or flight arousal pattern characterized by fairly direct manifestations of striated muscle tension as well as cardiorespiratory activity. In contrast, Factor I is a complex arousal pattern characterized by diffuse autonomic arousal, self-directed attention, and possibly low self-esteem. The results of this study draw into question the extent to which popular stress inventories tap a representative sample of stress symptoms. Clinical implications are discussed.The authors wish to thank Patrick Corrigan for his considerable statistical assistance. 相似文献
17.
18.
This study aimed to validate a Chinese’s adaption of the Cognitive Emotion Regulation Questionnaire for children (CERQ-Ck). This self-report instrument evaluates nine cognitive emotion regulation strategies that can be used by children after experiencing a negative life event. The CERQ-Ck was evaluated in a sample of 1403 elementary students between the ages of 9 and 11 by using cluster sampling. All the item-correlation coefficients for CERQ-Ck were above 0.30. The internal consistencies of the nine factors suggested moderate reliability (0.66 to 0.73). Confirmatory factor analysis (CFA) indicated that the current version had the same structure as the original instrument (Tucker–Lewis index = 0.912, comparative fit index = 0.922, root mean square error of approximation = 0.032, standardized root mean square residual = 0.044). A second-order factor and a third-order factor structure were also found. Test–retest correlations (0.53 to 0.70, ps < 0.01) over a period of 1 month, which ranged from acceptable to moderately strong were obtained from a random and stratified subsample of elementary students (N = 76). In addition, we analyzed convergent validity in relation to CERQ-Ck and the Chinese version of the Children’s Depression Inventory model dimensions with a subsample of 1083 elementary students. Multiple-group CFA confirmed the measurement invariance for both the male and female groups (ΔCFI < 0.01, ΔRMSEA < 0.015). Overall, results indicate that CERQ-Ck has similar psychometric properties to the original instrument as well as with adequate reliability and validity to investigate the nine cognitive emotion regulation strategies during late childhood developmental periods. 相似文献
19.
Radiation therapy of the CNS, even at low doses, can lead to deficits in neurocognitive functions. Reduction in hippocampal neurogenesis is usually, but not always, associated with cognitive deficits resulting from radiation therapy. Generation of reactive oxygen species is considered the main cause of radiation-induced tissue injuries, and elevated levels of oxidative stress persist long after the initial cranial irradiation. Consequently, mutant mice with reduced levels of the mitochondrial antioxidant enzyme, Mn superoxide dismutase (MnSOD or Sod2), are expected to be more sensitive to radiation-induced changes in hippocampal neurogenesis and the related functions. In this study, we showed that MnSOD deficiency led to reduced generation of immature neurons in Sod2−/+ mice even though progenitor cell proliferation was not affected. Compared to irradiated Sod2+/+ mice, which showed cognitive defects and reduced differentiation of newborn cells towards the neuronal lineage, irradiated Sod2−/+ mice showed normal hippocampal-dependent cognitive functions and normal differentiation pattern for newborn neurons and astroglia. However, we also observed a disproportional decrease in newborn neurons in irradiated Sod2−/+ following behavioral studies, suggesting that MnSOD deficiency may render newborn neurons more sensitive to stress from behavioral trainings following cranial irradiation. A positive correlation between normal cognitive functions and normal dendritic spine densities in dentate granule cells was observed. The data suggest that maintenance of synaptic connections, via maintenance of dendritic spines, may be important for normal cognitive functions following cranial irradiation. 相似文献
20.
Diesfeldt HF 《Tijdschrift voor gerontologie en geriatrie》2004,35(6):224-233
The Depression List is a Dutch self-report measure of depressive symptoms in persons with dementia. Fifteen items differ to the extent that they provide reliable measurements of latent constructs such as feeling depressed, tired or lonely. Item scalability and construct reliability were studied by administering the questionnaire to 599 consecutive visitors of a psychogeriatric day care department. Using confirmatory factor analysis three competing hypothetical models were tested for model fit. A four-factor model composed of latent constructs for feeling depressed, tired, lonesome and appetite or sleep disturbance provided an adequate fit to the clinical data, which did not apply to a two-factor model (distinguishing a construct of loneliness from a more general mood construct) and a one-factor model, that hypothesized a single general mood construct for all fifteen items. Nine items carried relatively small proportions of error variance. These reliable items were selected for the construction of three scales that satisfied the assumptions of Mokken's criteria for homogeneity. The resulting measures of feeling depressed, tired or lonely showed evidence of convergent validity for a latent affective construct. The affective measures were not associated with severity of cognitive impairment (discriminant validity). The three scales allow a reliable measurement of differences in affective function in cognitively impaired subjects. 相似文献