共查询到20条相似文献,搜索用时 15 毫秒
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Control of transcription activation by steroid hormone receptors. 总被引:11,自引:0,他引:11
H Gronemeyer 《FASEB journal》1992,6(8):2524-2529
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T Hirano 《Biochemical and biophysical research communications》1999,260(2):303-308
Cytokines and growth factors play pivotal roles in cell growth, differentiation, and cell survival. Ligand binding to the receptors induces dimerization or oligomerization of the receptors, resulting in the activation of a variety of signal transduction pathways. The interplay among these multiple signals is critically involved in the biological activities of cytokines and growth factors. In this minireview, I discuss two models. One is the "receptor conversion model": The complex of cytokine and its soluble form of receptor acts like a cytokine with novel target specificity. The other is the "orchestrating model": Cytokines can simultaneously generate contradictory signals in the same target cells and the balance of each contradictory signal may determine the final output of cytokine signals to express unified biological activity. These mechanisms are part of the molecular basis underlying functional pleiotropy of cytokines and growth factors. 相似文献
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Signaling pathways mediated by tumor necrosis factor alpha 总被引:6,自引:0,他引:6
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