共查询到20条相似文献,搜索用时 11 毫秒
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M A Shupnik W W Chin J F Habener E C Ridgway 《The Journal of biological chemistry》1985,260(5):2900-2903
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Gene regulation through chromatin remodelling by members of the nuclear receptor superfamily 总被引:1,自引:0,他引:1
McEwan IJ 《Biochemical Society transactions》2000,28(4):369-373
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Isolation and characterization of human TR3 receptor: a member of steroid receptor superfamily 总被引:5,自引:0,他引:5
Complementary DNAs (cDNAs) encoding a member of steroid receptor super-family, named TR3 receptor, were isolated from a human prostate lambda gt11 cDNA library on the basis of homology of oligonucleotide probes to the DNA-binding domain common to members of the steroid receptor super-family. Expression of TR3 receptor cDNA produced a 64 kDa DNA-binding protein in a rabbit reticulocyte lysate. Nucleotide sequence analysis showed that TR3 receptor cDNA contains two regions of sequences which correspond to the DNA- and hormone-binding domains of members of the steroid receptor super-family. The amino acid sequences in the hormone-binding domain of the TR3 receptor shares about 20% homology with estrogen receptor and less than 15% homology with other known steroid receptors. The DNA-binding domain of the TR3 receptor has about 55% homology with all other known steroid receptors. TR3 receptor had 86% nucleotide and 91% amino acid sequence homology with mouse NUR/77, suggesting that TR3 receptor may be a human homologue of mouse NUR/77 gene product. 相似文献
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