共查询到20条相似文献,搜索用时 31 毫秒
1.
Philipp N Seibel Jan Krüger Sven Hartmeier Knut Schwarzer Kai L?wenthal Henning Mersch Thomas Dandekar Robert Giegerich 《BMC bioinformatics》2006,7(1):490
Background
Today, there is a growing need in bioinformatics to combine available software tools into chains, thus building complex applications from existing single-task tools. To create such workflows, the tools involved have to be able to work with each other's data – therefore, a common set of well-defined data formats is needed. Unfortunately, current bioinformatic tools use a great variety of heterogeneous formats. 相似文献2.
Background
Scoring functions, such as molecular mechanic forcefields and statistical potentials are fundamentally important tools in protein structure modeling and quality assessment. 相似文献3.
Ramkumar Menon Brad Pearce Digna R Velez Mario Merialdi Scott M Williams Stephen J Fortunato Poul Thorsen 《Reproductive biology and endocrinology : RB&E》2009,7(1):62
Objective
To study pathophysiologic pathways in spontaneous preterm birth and possibly the racial disparity associating with maternal and fetal genetic variations, using bioinformatics tools. 相似文献4.
Brian Fristensky 《BMC bioinformatics》2007,8(1):54
Background
Molecular biologists need sophisticated analytical tools which often demand extensive computational resources. While finding, installing, and using these tools can be challenging, pipelining data from one program to the next is particularly awkward, especially when using web-based programs. At the same time, system administrators tasked with maintaining these tools do not always appreciate the needs of research biologists. 相似文献5.
Background
A common method for presenting and studying biological interaction networks is visualization. Software tools can enhance our ability to explore network visualizations and improve our understanding of biological systems, particularly when these tools offer analysis capabilities. However, most published network visualizations are static representations that do not support user interaction. 相似文献6.
Background
The growing need for functional studies of genes has set the stage for the development of versatile tools for genetic manipulations. 相似文献7.
Morgenstern B Prohaska SJ Pöhler D Stadler PF 《Algorithms for molecular biology : AMB》2006,1(1):6-12
Background
Automated software tools for multiple alignment often fail to produce biologically meaningful results. In such situations, expert knowledge can help to improve the quality of alignments. 相似文献8.
9.
Background
To aid in bioinformatics data processing and analysis, an increasing number of web-based applications are being deployed. Although this is a positive circumstance in general, the proliferation of tools makes it difficult to find the right tool, or more importantly, the right set of tools that can work together to solve real complex problems. 相似文献10.
Background
Predicting metabolic sites is important in the drug discovery process to aid in rapid compound optimisation. No interactive tool exists and most of the useful tools are quite expensive. 相似文献11.
Robert C Edgar 《BMC bioinformatics》2007,8(1):18
Background
Sequencing of prokaryotic genomes has recently revealed the presence of CRISPR elements: short, highly conserved repeats separated by unique sequences of similar length. The distinctive sequence signature of CRISPR repeats can be found using general-purpose repeat- or pattern-finding software tools. However, the output of such tools is not always ideal for studying these repeats, and significant effort is sometimes needed to build additional tools and perform manual analysis of the output. 相似文献12.
Sohrab?P?Shah David?YM?He Jessica?N?Sawkins Jeffrey?C?Druce Gerald?Quon Drew?Lett Grace?XY?Zheng Tao?Xu BF?Francis?Ouellette
Background
We present Pegasys – a flexible, modular and customizable software system that facilitates the execution and data integration from heterogeneous biological sequence analysis tools. 相似文献13.
Background
Profile hidden Markov models (profile-HMMs) are sensitive tools for remote protein homology detection, but the main scoring algorithms, Viterbi or Forward, require considerable time to search large sequence databases. 相似文献14.
Background
Sequence data analyses such as gene identification, structure modeling or phylogenetic tree inference involve a variety of bioinformatics software tools. Due to the heterogeneity of bioinformatics tools in usage and data requirements, scientists spend much effort on technical issues including data format, storage and management of input and output, and memorization of numerous parameters and multi-step analysis procedures. 相似文献15.
Background
Common existing phylogenetic tree visualisation tools are not able to display readable trees with more than a few thousand nodes. These existing methodologies are based in two dimensional space. 相似文献16.
Background
Microarray and other high-throughput technologies are producing large sets of interesting genes that are difficult to analyze directly. Bioinformatics tools are needed to interpret the functional information in the gene sets. 相似文献17.
Background
Realistic modeling of cardiac inter-beat (RR) intervals is highly desirable for basic research in cardiac electrophysiology, clinical management of heart diseases, and developing signal processing tools for ECG analysis. 相似文献18.
Thomas Kuhn Egon L Willighagen Achim Zielesny Christoph Steinbeck 《BMC bioinformatics》2010,11(1):159
Background
Small molecules are of increasing interest for bioinformatics in areas such as metabolomics and drug discovery. The recent release of large open access chemistry databases generates a demand for flexible tools to process them and discover new knowledge. To freely support open science based on these data resources, it is desirable for the processing tools to be open source and available for everyone. 相似文献19.
Background
Construction and interpretation of phylogenetic trees has been a major research topic for understanding the evolution of genes. Increases in sequence data and complexity are creating a need for more powerful and insightful tree visualization tools. 相似文献20.