共查询到20条相似文献,搜索用时 31 毫秒
1.
G. P. Udalova S. V. Kholodkevich V. P. Fedotov E. L. Kornienko 《Inland Water Biology》2012,5(1):119-127
The changes in heart rate and circadian cardiac rhythm of crayfish Pontastacus leptodactylus Esch. kept in a lightning regime that is close to natural under optimal or low pH values were studied. The heart rate was
registered in real time using an original noninvasive fiberoptic method. Upon acidification, disorders in circadian cardiac
rhythm and organism reaction (by heart rate) in the suspension test were detected. The characteristics of cardiac activity
are considered criteria for estimating the crayfish’s functional state at normal and stress conditions caused by the changes
in the quality of the environment. 相似文献
2.
Demin DB Poskotinova LV Krivonogova EV 《Rossi?skii fiziologicheski? zhurnal imeni I.M. Sechenova / Rossi?skaia akademiia nauk》2011,97(11):1262-1269
Types of neurophysiologic and thyroid condition in 15-17-year old adolescents were studied for the purpose of heart rhythm biofeedback session effect by heart rhythm variability parameters. Changes of heart rhythm vegetative regulation activity modulate functional capacities of central vegetative regulation structures. The biofeedback training with heart rhythm variability parameters increases brain bioelectrical activity in different frequency ranges. The thyroid system modulates functional activity of vegetative regulation central structures uppermost at sympathotonic and thyreotropin increasing leads to increase of rhythm maker structure reactivity in brain. 相似文献
3.
Schmidt Krzysztof Nakanishi Nozomi Izawa Masako Okamura Maki Watanabe Shinichi Tanaka Sachiko Doi Teruo 《Journal of Ethology》2009,27(1):165-174
Felids are generally considered to be crepuscular and nocturnal in their activity, but few studies have attempted to analyze
the variability of their activity patterns. We studied the daily activity of the Iriomote cat Prionailurus iriomotensis by radio-tracking on Iriomote Island, Japan. The general activity patterns of Iriomote cats showed slightly prevailing activity
during dark periods of the day with particular peaks at dawn and dusk or during the early hours of the night. However, these
patterns were clearly dependent on the sex and reproductive status of the cat. Peaks of cats’ activity coincided with those
of their main prey. On average, the cats were active for thirteen hours per day. During the mating season, the rhythm of activity
in males followed that of breeding females, but not that of non-breeding ones. Males exhibited 11% higher total daily activity
and longer active bouts during the mating period than in the remainder of the year. Breeding females had additional mid-day
activity peak during the nursing period, but their total time of activity per day was 16% lower than in the period of kittens’
independence. Their active bouts were shorter and more frequent during nursing than at other times. These results suggest
that lactating females perform frequent movements to and from the den site to care for kittens. During the non-nursing period,
females increased their activity, possibly in response to lowered prey abundance and the need of intensive foraging to recover
after lactation. Seasonal and sexual variation of activity patterns in the Iriomote cats confirmed the existence of different
reproductive strategies of males and females of these solitary carnivores. 相似文献
4.
A. V. Bursian L. E. Dmitrieva V. A. Sizonov 《Journal of Evolutionary Biochemistry and Physiology》2011,47(4):366-373
Changes in the heart basic rhythm, its rhythmical variations on periodograms, and level of spontaneous motor activity were
studied on offspring of white rats from newborn to 3-week age at transition from the state of active wakefulness to narcosis
as well as under conditions of blockade of M-cholinoreceptors with atropine. It is shown that the endogenous rhythmical activity
can be regulated not only by a change in frequency of basic rhythms, but also by action on all parameters and properties of
their rhythmical variations and secondary rhythms. The changes in power of the heart secondary rhythms exceed considerably
the frequency oscillations of basic rhythms during blockade of cholinergic innervation or a change in the motor activity level
that affects both the basic rhythm circulation and respiration and their variations—secondary rhythms. The atropine blockade
of M-cholinoreceptors at the studied ages changes the heart contraction rhythm within the limits of 10% of bradycardia in
newborns to tachycardia in the 3-week old animals. At the same time, power of the cardiac rhythm secondary oscillations changes
several times. These data indicate that the cholinergic mechanisms play the key role in formation of the secondary rhythms
and their correlation with motor activity. 相似文献
5.
Perez-Lloret S Risk M Golombek DA Cardinali DP Sanchez R Ramirez A 《Chronobiology international》2008,25(1):99-113
24 h and ultradian rhythms of blood pressure (BP) have been previously shown to be disorganized in nocturnal hypertensive subjects. The present study was undertaken to further analyze the ultradian and circadian BP rhythm structure in sleep-time hypertensive subjects with normal or elevated awake-time BP levels. Fourier analysis was used to fit 24, 12, 8, and 6 h curves to mean BP as well as heart rate (HR) time series data derived from 24 h ambulatory blood pressure monitoring. Awake and sleep periods were defined according to individual sleep diaries. Awake-time hypertension was defined as diurnal systolic (SBP) and/or diastolic BP (DBP) means ≥135/85 mmHg. Sleep-time hypertension was defined as nocturnal SBP and/or DBP means ≥120/70 mmHg. The sample included 240 awake-time normotensive subjects (180 sleep-time normotensives and 60 sleep-time hypertensives) and 138 untreated awake-time hypertensive subjects (31 sleep-time normotensives and 107 sleep-time hypertensives). The amplitude and integrity (i.e., percent rhythm) of the 24 and 12 h BP rhythms were lower in the sleep-time hypertensive subjects and higher in the awake-time hypertensive subjects. However, no differences were detected when the integrity and amplitude of the 6 and 8 h mean BP rhythms were analyzed. The sleep-time hypertensive group showed significantly higher 24 h BP rhythm acrophase variability. No differences could be found in any of the HR rhythm parameters. Altogether, the findings suggest a disorganization of the BP circadian rhythm in sleep-time hypertensives that results in reduced 24 h rhythm amplitude and integrity that could be related to cardiovascular risk. 相似文献
6.
Tomasz H. Szymura 《Trees - Structure and Function》2009,23(2):211-217
Changes in the content of Cd, Ni, Pb, Zn, Fe, Mg, Mn, Ca, P, K, and N in six age classes of silver fir (Abies alba Mill.) needles were described as a function of the needles’ age. The raw measurements of each element’s concentration were
standardized at the level of an individual tree; such a procedure reduced the variability caused by differences in the absolute
content of an element between individual trees. The changes in the content of Fe at both sites, and of Pb and Cd at one site
were characterized by linear increase. The content of N, P, K, and Mg decreased exponentially, whereas the concentrations
of Ca, Mn, and Zn increased exponentially with the needles’ age at all sites. Only the concentration of Ni revealed erratic
behavior at both sites. 相似文献
7.
Hanna Pawluk Robert Pawluk Kornelia Kędziora-Kornatowska Józef Kędziora 《Redox report : communications in free radical research》2017,22(6):542-546
Objective: The objective of the present study was to examine selected parameters of the blood redox system in elderly patients with hypertension.examine selected parameters of the blood redox system in elderly patients with hypertension. Methods: We analyzed differences in redox-associated molecules and enzymes among elderly hypertensive subjects (age above 65?years, n?=?49) and two groups of normotensive subjects (<65 years old – Control group I; n?=?27, and >65 – Control group II; n?=?30). Results: Decreased activity of antioxidant enzymes, increased lipid peroxidation and reduced production of nitric oxide were observed in hypertensive subjects, compared to healthy younger controls, or those of the same age. In healthy controls, an age-related decrease in the production of nitric oxide and the activities of SOD-1 and GPx-1 was also evident. The pathology of hypertension was characterised by further, significant decreases in the values of these parameters. When the subgroups of females and males were compared to their respective controls, a compromised redox balance was observed that was more evident in female hypertensives. Discussion: Hypertension in elderly patients is accompanied by changes in biomarkers of antioxidant status and lipid peroxidation status, which significantly differ from those observed in healthy ageing subjects. Our study also suggests that the relationship of gender and changes in redox balance with regard to hypertension should be further explored. 相似文献
8.
Santana DB Armentano RL Zócalo Y Pérez Cámpos H Cabrera FE Graf S Saldías M Silva W Alvarez I 《Cell and tissue banking》2007,8(1):43-57
The ideal arterial graft must share identical functional properties with the host artery. Surgical reconstruction of the common
carotid artery (CA) is performed in several clinical situations, using expanded polytetrafluoroethylene prosthesis (ePTFE)
or saphenous vein (SV) grafts. At date there is interest in obtaining an arterial graft that improves the results of that
nowadays available. The use of a fresh or cryopreserved/defrosted artery appears as an interesting alternative. However, if
the fresh and cryopreserved/defrosted arteries allow an adequate viscoelastic and functional matching with the host arteries
needs to be established. The aims were to compare the viscoelastic and functional performance of: (1) conduits used in CA
reconstruction (SV and ePTFE) with those of the fresh and cryopreserved/defrosted CA and femoral arteries (FA), and (2) normotensive
and hypertensive patients’ arteries with those of the arterial substitutes in vitro analyzed. Pressure, diameter and wall thickness of the CA were recorded in 15 normotensive and 15 hypertensive patients (in vivo studies), and in SV, fresh and cryopreserved/defrosted CA and FA (obtained from 15 donors), and ePTFE segments (in vitro studies). From stress–strain relationship we calculated elastic and viscous modulus, and the characteristic impedance. The
local buffer and conduit functions were quantified as the viscous/elastic quotient and the inverse of the characteristic impedance.
Fresh and cryopreserved/defrosted CA and FA were more alike, both in viscoelastic and functional levels, respect to normotensive
and hypertensive patients’ arteries, than the ePTFE and SV grafts. CA and FA cryografts could be considered an important alternative
for carotid reconstruction. 相似文献
9.
A great majority of salinity studies have dealt with intertidal species. Little is known about the way subtidal animals respond
to salinity fluctuations. Even less details are available on invertebrates from the White Sea, which salinity is ca. 25. The
heart rate of two subtidal Bivalvia—Hiatella arctica and Modiolus modiolus—exposed to different salinities was recorded. Changes in cardiac activity were monitored for 9 days of the animals’ acclimation
to salinities of 15, 20, 30 and 35, and for 4 days of reacclimation (return to the initial salinity of 25). The initial response
to salinity change was a significant heart rate reduction. On the other hand, cardiac activity in M. modiolus intensified at salinities of 30 and 35. Reacclimation induced different HR responses: from a decrease to a rise, depending
on the species and the salinity applied in the experiment. The differences in responses to salinity are discussed with respect
to the morphological and ecological characteristics of the species. 相似文献
10.
Modulation of a turgor-growth movement called circumnutation in sunflower (Helianthus annuus L.) was investigated using a picture analysis system. Two photoperiod conditions were applied: light–darkness conditions
(LD) 8:8 and LD 20:10. After about 3 weeks of these regimes, the plants were placed under constant light to determine whether
circadian regulation of circumnutation existed or not. The rhythms of movement activity with regard to the trajectory length,
period, and shape of individual circumnutations were examined. Data were processed by Fourier spectral analysis. All the parameters,
trajectory length, period, and shape, revealed the ability to entrain to the administered daily cycles (16 h or 30 h). We
observed diurnal fluctuations of the circumnutation parameters with the phase of the highest trajectory length, the shortest
period, and the highest shape coefficient (the most circular form) during the dark period. After the LD–LL transition, the
parameters revealed periodicity, which was close to 24 h. After several days of a clear circadian free running rhythm, a gradual
decrease of the amplitude of the rhythm was observed. However, the rhythm did not disappear completely. The trajectory length
manifested the strongest entrainment; the circumnutation period and the circumnutation shape were less modulated by photoperiod.
These findings indicate for the first time that different parameters of circumnutation in sunflower are circadian-regulated
rhythms, not solely ultradian as had been thought previously. 相似文献
11.
Mustapha Ennajeh Ahmadou Mohamed Vadel Habib Khemira 《Acta Physiologiae Plantarum》2009,31(4):711-721
In this study, we compared the efficacy of defense mechanisms against severe water deficit in the leaves of two olive (Olea europaea L.) cultivars, ‘Chemlali’ and ‘Meski’, reputed drought resistant and drought sensitive, respectively. Two-year old plants
growing in sand filled 10-dm3 pots were not watered for 2 months. Changes in chlorophyll fluorescence parameters and malondialdehyde content as leaf relative
water content (RWC) decreased showed that ‘Chemlali’ was able to maintain functional and structural cell integrity longer
than ‘Meski’. Mannitol started to accumulate later in the leaves of ‘Chemlali’ but reached higher levels than in the leaves
of ‘Meski’. The latter accumulated several soluble sugars at lower dehydration. ‘Chemlali’ leaves also accumulated larger
quantities of phenolic compounds which can improve its antioxidant response. Furthermore, the activity of three antioxidant
enzymes catalase (CAT), peroxidase (POD) and ascorbate peroxidase (APX) increased as leaf RWC decreased. However, differences
were observed between the two cultivars for CAT and POD but not for APX. The activity of the first two enzymes increased earlier
in ‘Meski’, but reached higher levels in ‘Chemlali’. At low leaf hydration levels, ‘Chemlali’ leaves accumulated mannitol
and phenolic compounds and had increased CAT and POD activities. These observations suggest that ‘Chemlali’ was more capable
of maintaining its leaf cell integrity under severe water stress because of more efficient osmoprotection and antioxidation
mechanisms. 相似文献
12.
The degree of activation of the central stepping program during passive leg movement was studied in healthy subjects under
unloading conditions; the excitability of spinal motoneurons was studied during passive and voluntary stepping movements.
Passive stepping movements with characteristics maximally close to those during voluntary stepping were accomplished by the
experimenter. The bursts of muscular activity during voluntary and imposed stepping movements were compared. In addition,
the influence on the leg movement of artificially created loading onto the foot was studied. The excitability of spinal motoneurons
was estimated by the amplitude of modulation of the m. soleus H reflex. Changes in the H reflex (Hoffmann’s reflex) after fixation of the knee and hip joints were also studied. In most subjects, passive movements
were accompanied by bursts of electromyographic (EMG) activity in the hip muscles (sometimes in shank muscles); the timing
of the EMG burst during the step cycle coincided with the burst’s timing during voluntary stepping. In many cases, the bursts
in EMG activity exceeded the activity of homonymous muscles during voluntary stepping. Simulation of foot loading influenced
significantly the distal part of the moving extremity during both voluntary and passive movements, which was expressed in
the appearance of movements in the ankle joint and an increase in the phasic EMG activity of the shank muscles. The excitability
of motoneurons during passive movements was higher than during voluntary movements. Changes and modulation of the H reflex throughout the step cycle were similar without restriction of joint mobility and without hip joint mobility. Fixation
of the knee joint was of great importance. It is supposed that imposed movements activate the same mechanisms of rhythm generation
as supraspinal commands during voluntary movements. During passive movements, presynaptic inhibition depends mostly on the
afferent influences from the moving leg rather than on the central commands. Under the conditions of “air-stepping,” the afferent
influences from the foot pressure receptors are likely to interact actively with the central program of stepping and to determine
the final activity pattern irrespective of the movement type (voluntary or passive). 相似文献
13.
Alfonso Mate José L. Miguel-Carrasco María T. Monserrat Carmen M. Vázquez 《Journal of physiology and biochemistry》2010,66(2):127-136
In spite of a wide range of drugs being available in the market, treatment of arterial hypertension still remains a challenge,
and new therapeutic strategies could be developed in order to improve the rate of success in controlling this disease. Since
oxidative stress has gained importance in the last few years as one of the mechanisms involved in the origin and development
of hypertension, and considering that L-carnitine (LC) is a useful compound in different pathologies characterized by increased
oxidative status, the aim of the present study was to investigate the systemic antioxidant effect of LC and its correlation
to blood pressure in two experimental models of hypertension: (1) spontaneously hypertensive rats (SHR) and (2) rats with
hypertension induced by Nω-nitro-L-arginine methyl ester (L-NAME). Treatment with captopril was also performed in SHR in order to compare the antioxidant
and antihypertensive effects of LC and captopril. The antioxidant defense capacity, in terms of antioxidant enzyme activity,
glutathione system availability and plasma total antioxidant capacity, was measured in both animal models with or without
an oral, chronic treatment with LC. All the antioxidant parameters studied were diminished in SHR and in L-NAME-treated animals,
an alteration that was in general reversed after treatments with LC and captopril. In addition, LC produced a significant
but not complete reduction of systolic and diastolic blood pressure levels in these two models of hypertension, whereas captopril
was able to normalize blood pressure. Both LC and captopril prevented the reduction in nitric oxide (NO) levels observed in
hypertensive animals. This suggests a decrease in the systemic oxidative stress and a higher availability of NO induced by
LC in a similar way to captopril’s effects, which could be relevant in the management of arterial hypertension eventually. 相似文献
14.
The aim of this study was to determine the levels of tissue and blood zinc (Zn), copper (Cu), magnesium (Mg) in nitric oxide
(NO) synthase blockade-induced hypertension. A group of albino rats received a NO synthase inhibitor, N
G
-nitro-l-arginine-methyl ester (l-NAME, 60 mg/kg/d) in their drinking water for 21 d. l-NAME intake caused a progressive rise in this group’s resting mean arterial blood pressure compared to a control group (p<0.01). There were no differences between the groups with regard to tissue and blood levels of Zn or Cu; however, Mg concentrations
were significantly lower in the hypertensive rats’ erythrocytes (20.2% reduction from control levels), cerebral cortex (17.0%),
heart (9.1%), renal cortex (12%), renal medulla (16.7%), and in the tissues of the caval vein (23.7%), mesenteric artery (29.8%),
renal artery (18.4%), and renal vein (22.1%). There were no significant Mg concentration changes in the hypertensive group’s
plasma, cerebellum, liver, duodenum, or aortal tissue. These findings suggest that Mg depletion may play a role in the blood
pressure rise that occurs in the model of chronic NO synthase inhibition-induced hypertension. 相似文献
15.
A simulation model has been developed for predicting the distribution of trinucleotide repeat expansion diseases in human
populations. The interface of the software used to run this model presents the options for simulating natural reproduction
of a population, with the population demographic parameters taken into account, and for simulating the appearance of a dynamic
mutation in populations, transmission of the mutant gene from parents to offspring, and the effect of the phenotypic expression
of the disease (the patients’ life expectancy and birthrate) on the transmission of the mutant allele in the patients’ families
and its accumulation in the population. 相似文献
16.
In chronic experiments on awake cats, we studied the dynamics of the spectral power density (SPD) of the α rhythm vs SPD of the θ rhythm ratio and also of the characteristics of impulse activity generated by supposedly noradrenergic (NA)
neurons of the locus coeruleus in the course of feedback (FB) sessions by EEG characteristics (EEG-FB). Trainings were performed using a technique analogous
to that in EEG-FB sessions for humans. The level of a sound noise signal presented to the animal decreased with increase in
the α/θ SPD ratio in the occipital lead. Changes in the level of the sound signal did not depend on EEG modulation in the
control series. The animals were trained to correlate changes in the loudness of the sound signal with the power of EEG rhythms
and, in such a way, to control the latter. The α/θ SPD ratio in EEG-FB sessions changed mostly due to a significant increase
in the α rhythm power. The frequency of the impulse activity of NA neurons increased in a parallel manner with such EEG modulation.
Possible mechanisms of the involvement of the cerebral NA system in the formation of the effects of EEG-FB sessions are discussed. 相似文献
17.
Transgenic hypertensive TGR(mREN2)27 rats (TGR) exhibit an inverse circadian blood pressure profile from the age of 8 to 9 wk. To investigate the role of the sympathetic nervous system in this pathological blood pressure rhythm, we examined postnatal changes in catecholamine concentration, expression of tyrosine-hydroxylase (TH), and norepinephrine (NE) reuptake1-transporter (NET) in the heart, adrenal glands, and hypothalamus of non-hypertensive TGR at an age of 4 wk and of hypertensive TGR at an age of 10 wk and compared these to normotensive, age-matched Sprague-Dawley rats. Rats were kept under synchronized light:dark (LD) conditions of 12:12 h. Blood pressure and heart rate were monitored by radiotelemetry, catecholamines by high performance liquid chromatography, expression of TH and NET (mRNA) by RT-PCR, and TH protein by Western blots. In normotensive 4 wk-old Sprague-Dawley rats, cardiac NE concentrations were circadian phase-dependent with lower values at ZT12.5, with no differences observed, in 10-wk-old animals. At both ages however, sympathetic tone was higher during the dark phase, as shown by a higher turnover of NE. This observation confirms earlier data, which indicate that the endogenous amine concentration may not mirror its turnover rate. TGR at either age had lower cardiac NE as well as lower TH expression and did not display a circadian phase-dependency. The increased cardiac NE turnover rate in the dark phase in non-hypertensive TGR was lost in hypertensive rats. Both cardiac NE concentrations and TH expression decreased with age in both strains. In adrenal glands, NE and epinephrine (E) were not circadian phase-dependent in both strains but increased with age. NE concentrations in the hypothalamus were neither circadian phase-dependent nor different in both strains and at both ages. However, sympathetic tone of NE in the hypothalamus, as indicated by the turnover rate, was greater during the dark phase in both strains at an age of 10 wk. Expression of TH and NET were greatly reduced in adrenal glands when compared to Sprague-Dawley rats; whereas, expression of TH in the hypothalamus was significantly increased in hypertensive TGR. These data indicate that the transgene in TGR leads to an increased central stimulation of the sympathetic nervous system and to a consecutive down-regulation in the peripheral organs. It is of interest that rhythmicity in the studied parameters was lost in hypertensive TGR, except in the turnover of NE in the hypothalamus. We concluded that the data on key mechanisms of regulation of the sympathetic system in TGR cannot explain the inverse blood pressure rhythm observed in this transgenic rat strain. 相似文献
18.
I. N. Konareva 《Neurophysiology》2006,38(3):201-208
Modifications of different EEG rhythms induced by a single neurofeedback session (by the EEG characteristics) directed toward
an increase in the ratio of the spectral powers (SPs) of the α vs θ oscillations were compared with the psychological characteristics of the tested subjects (the group included 30 persons).
A generally accepted neurofeedback technique was used; the intensity of acoustic white noise served as the feedback signal.
EEG potentials were recorded from the C3 and C4 leads. Psychological testing was carried out using Eysenck’s (EPQ), Rusalov’s
(OST), and (16 PF) questionnaires. The directions of changes in the SPs of EEG frequency components were found to significantly
correlate with some individuality-related peculiarities of the tested subjects. The SP of the δ rhythm correlated with the
EPQ scale “neuroticism,” OST scale “social plasticity,” and 16 PF factors H (“parmia”), I (“premsia”), and Q3 (“self-control of behavior”). The SP of the θ component demonstrated correlations with the OST scales “ergisity,” “plasticity,”
and “social temp” and with 16 PF factors M (“autia”), Q4 (“frustration”), and Q1 (“exvia”). The SP of the α rhythm correlated with 16 PF factors Q3 (“self-control of behavior”), G (“strength of superEgo”), O (“hypothymia”), L (“protension”), and N (“shrewdness”). The SP
of the β rhythm correlated with the OST scale “emotionality,” while that of the γ rhythm showed correlations with the 16 PF
indices L (“protension”) and M (“autia”). Changes in the ratio of the α vs θ SPs correlated with the EPQ scale “neuroticism.” Thus, our data confirm the statement that a high individual variability
of the results of a single (first in the series) neurofeedback session is to a great extent related to peculiarities of the
individual psychological pattern of the subject.
Neirofiziologiya/Neurophysiology, Vol. 38, No. 3, pp. 239–247, May–June, 2006. 相似文献
19.
Karima Nasri-Ammar Raja Jelassi Anas Ayari Elfed Morgan 《Biological Rhythm Research》2016,47(1):25-38
The locomotor activity rhythm of the desert woodlouse Hemilepistus reaumurii was monitored as individuals over the four seasons, under entraining and constant darkness conditions. Results indicated that individuals exhibited an endogenous rhythm of locomotor activity with a circadian period longer in spring than the other seasons whatever the regimen. Due to the important inter-individual variability, no significant difference in period was found between seasons as well as between regimens. Periodogram analysis revealed also an ultradian period around 12 h. Activity was mostly confined to the hours of the photophase or to those of subjective day. The activity pattern showed two main peaks. This bimodal circadian rhythm persisted for as long as the experiments were run, and was clearer in summer and autumn than in winter. The most clearly defined rhythms were found in spring and summer recordings, respectively, under entraining and free running conditions. The variation of activity patterns according to the seasons will be discussed. 相似文献
20.
We conducted a lifetime study of the content of oxidized and methylated guanine in the urine of intact and irradiated mice.
For statistical processing of the results, we used the trial period method created by A.A. Konradov, which was unpublished
during the author’s lifetime. We prove that there are oscillating components in the age dependence of the concentration of
oxidized and methylated guanine in mice urine. For intact animals, a 7-month oscillation period is the most probable (p = 0.001). For irradiated mice, a disruption in the seasonal oscillation rhythm in the concentration of oxidized and methylated
guanine in urine was noted, which is peculiar to radiation-accelerated aging. 相似文献