共查询到20条相似文献,搜索用时 15 毫秒
1.
2.
3.
4.
5.
6.
7.
8.
John C. Sih 《Prostaglandins & other lipid mediators》1977,13(5):831-835
We wish to report here the total synthesis of the naturally occurring (19R)-19-hydroxy-prostaglandins of the PGE and PGF series. 相似文献
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
Inoculation of newborn mice with fecal samples from approximately 200 baboons (Papio cynocephalus) yielded an enterovirus (SV19) from four different animals. This virus previously had been found only in Asian monkeys (Macaca sp). 相似文献
19.
Shan Lu Renxian Wang Congli Cai Junbo Liang Longchang Xu Shiying Miao Linfang Wang Wei Song 《PloS one》2014,9(4)
Apoptosis is a regulated cellular suicide program that is critical for the development and maintenance of healthy tissues. Previous studies have shown that small kinetochore associated protein (SKAP) cooperates with kinetochore and mitotic spindle proteins to regulate mitosis. However, the role of SKAP in apoptosis has not been investigated. We have identified a new interaction involving SKAP, and we propose a mechanism through which SKAP regulates cell apoptosis. Our experiments demonstrate that both overexpression and knockdown of SKAP sensitize cells to UV-induced apoptosis. Further study has revealed that SKAP interacts with Pre-mRNA processing Factor 19 (Prp19). We find that UV-induced apoptosis can be inhibited by ectopic expression of Prp19, whereas silencing Prp19 has the opposite effect. Additionally, SKAP negatively regulates the protein levels of Prp19, whereas Prp19 does not alter SKAP expression. Finally, rescue experiments demonstrate that the pro-apoptotic role of SKAP is executed through Prp19. Taken together, these findings suggest that SKAP promotes UV-induced cell apoptosis by negatively regulating the anti-apoptotic protein Prp19. 相似文献
20.
Netherlands Heart Journal - 相似文献