共查询到20条相似文献,搜索用时 15 毫秒
1.
Tomoko Kawabata Keiichiro Nishida Koji Takasugi Hiroko Ogawa Kenei Sada Yasutaka Kadota Junko Inagaki Satoshi Hirohata Yoshifumi Ninomiya Hirofumi Makino 《Arthritis research & therapy》2010,12(4):R133-13
Introduction
The purpose of this study was to investigate the profile of histone deacetylase (HDAC) expression in the synovial tissue of rheumatoid arthritis (RA) compared with that of normal control and osteoarthritis (OA), and to examine whether there is a link between HDAC activity and synovial inflammation. 相似文献2.
Elena Neumann Birgit Riepl Anette Knedla Stephanie Lefèvre Ingo H Tarner Joachim Grifka Jurgen Steinmeyer Jurgen Schölmerich Steffen Gay Ulf Müller-Ladner 《Arthritis research & therapy》2010,12(3):R83
Introduction
Rheumatoid arthritis synovial fibroblasts (RASF) are key players in synovial pathophysiology and are therefore examined extensively in various experimental approaches. We evaluated, whether passaging during culture and freezing has effects on gene expression and cell proliferation. 相似文献3.
Ta-Liang Chen Yung-Feng Lin Chao-Wen Cheng Shi-Yun Chen Ming-Thau Sheu Ting-Kai Leung Cheng-Hong Qin Chien-Ho Chen 《Journal of biomedical science》2011,18(1):43
Background
Osteoarthritis (OA) is a degenerative joint disease which affects the entire joint structure, including the synovial membrane. Disease progression was shown to involve inflammatory changes mediated by proteinase-activated receptor (PAR)-2. Previous studies demonstrated that PAR-2 messenger (m)RNA and protein levels increased in OA synovial cells, suggesting that PAR-2 is a potential therapeutic target of the disease. 相似文献4.
Karina Roxana Gheorghe Marina Korotkova Anca Irinel Catrina Linda Backman Erik af Klint Hans-Erik Claesson Olof R?dmark Per-Johan Jakobsson 《Arthritis research & therapy》2009,11(3):R83
Introduction
It was previously shown that lipoxygenase (LO) pathways are important in the rheumatoid arthritis (RA) inflammatory process and that synovial fluid from RA patients contains high amounts of leukotrienes. We therefore aimed to investigate the 5-LO and 15-LO-1 expression pattern in RA and ostheoarthritis (OA) synovial tissue and to study the effect of intraarticular glucocorticoid (GC) therapy on enzyme expression. 相似文献5.
Ekwall AK Eisler T Anderberg C Jin C Karlsson N Brisslert M Bokarewa MI 《Arthritis research & therapy》2011,13(2):R40
Introduction
Activated fibroblast-like synoviocytes (FLSs) in rheumatoid arthritis (RA) share many characteristics with tumour cells and are key mediators of synovial tissue transformation and joint destruction. The glycoprotein podoplanin is upregulated in the invasive front of several human cancers and has been associated with epithelial-mesenchymal transition, increased cell migration and tissue invasion. The aim of this study was to investigate whether podoplanin is expressed in areas of synovial transformation in RA and especially in promigratory RA-FLS. 相似文献6.
Koichi Murata Hiroyuki Yoshitomi Shimei Tanida Masahiro Ishikawa Kohei Nishitani Hiromu Ito Takashi Nakamura 《Arthritis research & therapy》2010,12(3):R86
Introduction
MicroRNAs (miRNAs), endogenous small noncoding RNAs regulating the activities of target mRNAs and cellular processes, are present in human plasma in a stable form. In this study, we investigated whether miRNAs are also stably present in synovial fluids and whether plasma and synovial fluid miRNAs could be biomarkers of rheumatoid arthritis (RA) and osteoarthritis (OA). 相似文献7.
Introduction
The aim of this study was to quantify the number of T-helper (TH)-17 cells present in rheumatoid arthritis (RA) synovial fluid (SF) and to determine the level of interleukin (IL)-17 cytokine in RA, osteoarthritis (OA) and normal synovial tissue, as well as to examine SF macrophages for the presence of IL-23, IL-27 and interferon (IFN)-γ. 相似文献8.
Church LD Filer AD Hidalgo E Howlett KA Thomas AM Rapecki S Scheel-Toellner D Buckley CD Raza K 《Arthritis research & therapy》2010,12(5):R184
Introduction
Th17 cells have been implicated in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to systematically analyse the phenotype, cytokine profile and frequency of interleukin-17 (IL-17) producing CD4-positive T cells in mononuclear cells isolated from peripheral blood, synovial fluid and synovial tissue of RA patients with established disease, and to correlate cell frequencies with disease activity. 相似文献9.
Kokebie R Aggarwal R Lidder S Hakimiyan AA Rueger DC Block JA Chubinskaya S 《Arthritis research & therapy》2011,13(2):R50
Introduction
The purpose of this study was to correlate the level of anabolic and catabolic biomarkers in synovial fluid (SF) from patients with rheumatoid arthritis (RA), patients with osteoarthritis (OA) and asymptomatic organ donors. 相似文献10.
Miyamoto T Muneta T Tabuchi T Matsumoto K Saito H Tsuji K Sekiya I 《Arthritis research & therapy》2010,12(6):R206
Introduction
Synovial mesenchymal stem cells (MSCs) have high proliferative and chondrogenic potentials, and MSCs transplanted into the articular cartilage defect produce abundant extracellular matrix. Because of similarities between the articular cartilage and the intervertebral disc cartilage, synovial MSCs are a potential cell source for disc regeneration. Here, we examined the effect of intradiscal transplantation of synovial MSCs after aspiration of nucleus pulposus in rabbits. 相似文献11.
Onno J Arntz Jeroen Geurts Sharon Veenbergen Miranda B Bennink Ben T van den Brand Shahla Abdollahi-Roodsaz Wim B van den Berg Fons A van de Loo 《Arthritis research & therapy》2010,12(2):R61
Introduction
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that mainly affects synovial joints. Biologics directed against tumor-necrosis-factor (TNF)-α are efficacious in the treatment of RA. However, the role of TNF receptor-1 (TNFR1) in mediating the TNFα effects in RA has not been elucidated and conflicting data exist in experimental arthritis models. The objective is to investigate the role of TNFR1 in the synovial lining cells (SLC) and the reticuloendothelial system (RES) during experimental arthritis. 相似文献12.
David Pretzel Dirk Pohlers Sönke Weinert Raimund W Kinne 《Arthritis research & therapy》2009,11(1):R25-20
Introduction
Activated synovial fibroblasts are thought to play a major role in the destruction of cartilage in chronic, inflammatory rheumatoid arthritis (RA). However, profound insight into the pathogenic mechanisms and the impact of synovial fibroblasts in the initial early stages of cartilage destruction is limited. Hence, the present study sought to establish a standardised in vitro model for early cartilage destruction with native, intact cartilage in order to analyse the matrix-degrading capacity of synovial fibroblasts and their influence on cartilage metabolism. 相似文献13.
Valérie Badot Christine Galant Adrien Nzeusseu Toukap Ivan Theate Anne-Lise Maudoux Benoît J Van den Eynde Patrick Durez Frédéric A Houssiau Bernard R Lauwerys 《Arthritis research & therapy》2009,11(2):R57-13
Introduction
To identify markers and mechanisms of resistance to adalimumab therapy, we studied global gene expression profiles in synovial tissue specimens obtained from severe rheumatoid arthritis (RA) patients before and after initiation of treatment. 相似文献14.
Koga H Shimaya M Muneta T Nimura A Morito T Hayashi M Suzuki S Ju YJ Mochizuki T Sekiya I 《Arthritis research & therapy》2008,10(4):R84
Introduction
Current cell therapy for cartilage regeneration requires invasive procedures, periosteal coverage and scaffold use. We have developed a novel transplantation method with synovial mesenchymal stem cells (MSCs) to adhere to the cartilage defect. 相似文献15.
Mohammed A Akhavani Leigh Madden Ian Buysschaert Branavan Sivakumar Norbert Kang Ewa M Paleolog 《Arthritis research & therapy》2009,11(3):R64
Introduction
Rheumatoid arthritis (RA) is characterised by invasion of cartilage, bone and tendon by inflamed synovium. Previous studies in our laboratory have shown that hypoxia is a feature of RA synovitis. In the present study, we investigated the consequences of hypoxia on angiogenesis and synovial fibroblast migration in RA. 相似文献16.
Chun K Wong Da P Chen Lai S Tam Edmund K Li Yi B Yin Christopher WK Lam 《Arthritis research & therapy》2010,12(4):R129-15
Introduction
Interleukin (IL)-27 is a novel member of the IL-6/IL-12 family cytokines that are produced early by antigen-presenting cells in T helper (Th)1-mediated inflammation. Elevated expression of IL-27 has been detected in the synovial membranes and fluid of rheumatoid arthritis (RA). 相似文献17.
Appel H Maier R Wu P Scheer R Hempfing A Kayser R Thiel A Radbruch A Loddenkemper C Sieper J 《Arthritis research & therapy》2011,13(3):R95
Introduction
In this study, we analysed the number of IL-17+ cells in facet joints, in the peripheral blood (PB) and synovial fluid (SF) of spondyloarthritis (SpA) patients and compared these results with those of patients with other rheumatic diseases and controls. 相似文献18.
Introduction
Expression of TXNDC5, which is induced by hypoxia, stimulates cell proliferation and angiogenesis. Our previous study detected increased TXNDC5 expression in the synovial tissues of rheumatoid arthritis (RA) patients using proteomic methods. The current study investigated a pathogenic role for TXNDC5 in RA. 相似文献19.
20.
Julia Freise Iris Bernau Sabine Meier Henning Zeidler Jens G Kuipers 《Arthritis research & therapy》2009,11(6):R175-10