共查询到20条相似文献,搜索用时 15 毫秒
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Chen D Li Z Yang Q Zhang J Zhai Z Shu HB 《Biochemical and biophysical research communications》2003,310(3):720-724
Receptor-interacting protein (RIP) is a serine/threonine protein kinase that is critically involved in tumor necrosis factor receptor-1 (TNF-R1)-induced NF-kappaB activation. In a yeast two-hybrid screening for potential RIP-interacting proteins, we identified a novel protein designated as NKAP. Although NKAP interacts with RIP in yeast, NKAP does not interact with RIP in mammalian cells in co-immunoprecipitation experiments. When overexpressed in 293 cells, NKAP activated NF-kappaB in a dose-dependent manner. Moreover, down-regulation of NKAP by antisense RNA significantly inhibited TNF- and IL-1-induced NF-kappaB activation. Immunofluorescent staining indicated that NKAP was localized in the nucleus. Our findings suggest that NKAP is a novel nuclear regulator of TNF- and IL-1-induced NF-kappaB activation. 相似文献
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Oda T Ueda A Shimizu N Handa H Kasahara T 《Journal of immunology (Baltimore, Md. : 1950)》2002,169(6):3329-3335
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Takada Y Mukhopadhyay A Kundu GC Mahabeleshwar GH Singh S Aggarwal BB 《The Journal of biological chemistry》2003,278(26):24233-24241
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Ma W Gee K Lim W Chambers K Angel JB Kozlowski M Kumar A 《Journal of immunology (Baltimore, Md. : 1950)》2004,172(1):318-330