共查询到20条相似文献,搜索用时 15 毫秒
1.
Andrew S Warren Jeremy Archuleta Wu-chun Feng João Carlos Setubal 《BMC bioinformatics》2010,11(1):131
Background
Protein-coding gene detection in prokaryotic genomes is considered a much simpler problem than in intron-containing eukaryotic genomes. However there have been reports that prokaryotic gene finder programs have problems with small genes (either over-predicting or under-predicting). Therefore the question arises as to whether current genome annotations have systematically missing, small genes. 相似文献2.
Introduction
Findings that African-American race/ethnicity is associated with higher concentrations of serum urate have not been adjusted for possible confounding factors or have not explored this question as a primary outcome. We tested this hypothesis in a bi-racial cohort of younger African-American and white men and women. 相似文献3.
Lili Hao Xiaomeng Ge Haolei Wan Songnian Hu Martin J Lercher Jun Yu Wei-Hua Chen 《BMC evolutionary biology》2010,10(1):316
Background
Many functional, structural and evolutionary features of human genes have been observed to correlate with expression breadth and/or gene age. Here, we systematically explore these correlations. 相似文献4.
Background
Previous cost-effectiveness studies of cholinesterase inhibitors have modeled Alzheimer's disease (AD) progression and treatment effects through single or global severity measures, or progression to "Full Time Care". This analysis evaluates the cost-effectiveness of donepezil versus memantine or no treatment in Germany by considering correlated changes in cognition, behavior and function. 相似文献5.
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Background
Gene gain and subsequent retention or loss during evolution may be one of the underlying mechanisms involved in generating the diversity of metazoan nervous systems. However, the causal relationships acting therein have not been studied extensively. 相似文献7.
Bahram Hosseini-Maaf ?sa Hellberg Maria J Rodrigues M Alan Chester Martin L Olsson 《BMC genetics》2003,4(1):17
Background
Since the cloning in 1990 of cDNA corresponding to mRNA transcribed at the blood-group ABO locus, polymorphisms due to ethnic and/or phenotypic variations have been reported. Some subgroups have been explained at the molecular level, but unresolved samples are frequently encountered in the reference laboratory. 相似文献8.
Gelse K Pfander D Obier S Knaup KX Wiesener M Hennig FF Swoboda B 《Arthritis research & therapy》2008,10(5):R111
Introduction
Chondrocytes have to withstand considerable hypoxic conditions within the avascular articular cartilage. The present study investigated the effects of inhibiting or stabilizing hypoxia-inducible factor (HIF)-1α by 2-methoxyestradiol or dimethyloxaloylglycine on the progression of osteoarthritis in murine knee joints. 相似文献9.
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Background
The question of how a circle or line segment becomes covered when random arcs are marked off has arisen repeatedly in bioinformatics. The number of uncovered gaps is of particular interest. Approximate distributions for the number of gaps have been given in the literature, one motivation being ease of computation. Error bounds for these approximate distributions have not been given. 相似文献11.
Insights on the evolution of trehalose biosynthesis 总被引:3,自引:0,他引:3
Nelson Avonce Alfredo Mendoza-Vargas Enrique Morett Gabriel Iturriaga 《BMC evolutionary biology》2006,6(1):109-15
Background
The compatible solute trehalose is a non-reducing disaccharide, which accumulates upon heat, cold or osmotic stress. It was commonly accepted that trehalose is only present in extremophiles or cryptobiotic organisms. However, in recent years it has been shown that although higher plants do not accumulate trehalose at significant levels they have actively transcribed genes encoding the corresponding biosynthetic enzymes. 相似文献12.
Leila Hatami-Baroogh Shahnaz Razavi Hamid Zarkesh-Esfahani Marziyeh Tavalaee Somayeh Tanhaei Kamran Ghaedi Mohamad Reza Deemeh Farzaneh Rabiee Mohammad Hossein Nasr-Esfahani 《Reproductive biology and endocrinology : RB&E》2010,8(1):17
Background
Leptin, a 167 amino acid peptide hormone, profoundly effects reproduction exerting its biological effects via interaction with the leptin receptor (ObR) which is widely expressed on peripheral tissues. In this study, we have attempted to assess leptin receptor expression in the spermatozoa of fertile males and those diagnosed with male factor infertility; both at the mRNA or protein levels. 相似文献13.
Increasing the sensitivity of reverse phase protein arrays by antibody-mediated signal amplification
Jan C Brase Heiko Mannsperger Holger Fröhlich Stephan Gade Christian Schmidt Stefan Wiemann Tim Beissbarth Thorsten Schlomm Holger Sültmann Ulrike Korf 《Proteome science》2010,8(1):36
Background
Reverse phase protein arrays (RPPA) emerged as a useful experimental platform to analyze biological samples in a high-throughput format. Different signal detection methods have been described to generate a quantitative readout on RPPA including the use of fluorescently labeled antibodies. Increasing the sensitivity of RPPA approaches is important since many signaling proteins or posttranslational modifications are present at a low level. 相似文献14.
Background
Amino acid sequence probability distributions, or profiles, have been used successfully to predict secondary structure and local structure in proteins. Profile models assume the statistical independence of each position in the sequence, but the energetics of protein folding is better captured in a scoring function that is based on pairwise interactions, like a force field. 相似文献15.
Issa Dahabreh George Tsoutsos Dimitrios Tseligas Dimitrios Janinis 《BMC clinical pharmacology》2006,6(1):5-4
Background
Oxaliplatin is a platinum derivative, which is used in the treatment of colorectal cancer. A small number of oxaliplatin-related hemolytic and/or thrombocytopenic reactions have been reported. We present a case of hemolytic-uremic syndrome that developed during the 4th cycle of combination chemotherapy with oxaliplatin, 5-fluorouracil and leucovorin. 相似文献16.
Background
Calcium phosphate manufactured samples, prepared with hydroxyapatite, are used as either spacers or fillers in orthopedic surgery, but these implants have never been used under conditions of mechanical stress. Similar conditions also apply with cements. Many authors have postulated that cements are a useful substitute material when implanted in vivo. The aim of this research is to develop a low cristalline material similar to bone in porosity and cristallinity. 相似文献17.
Background
Experimental examinations of biofluids to measure concentrations of proteins or their fragments or metabolites are being explored as a means of early disease detection, distinguishing diseases with similar symptoms, and drug treatment efficacy. Many studies have produced classifiers with a high sensitivity and specificity, and it has been argued that accurate results necessarily imply some underlying biology-based features in the classifier. The simplest test of this conjecture is to examine datasets designed to contain no information with classifiers used in many published studies. 相似文献18.
Background
Ribonuclease P is an ancient endonuclease that cleaves precursor tRNA and generally consists of a catalytic RNA subunit (RPR) and one or more proteins (RPPs). It represents an important macromolecular complex and model system that is universally distributed in life. Its putative origins have inspired fundamental hypotheses, including the proposal of an ancient RNA world. 相似文献19.
Analysis and comparison of the pan-genomic properties of sixteen well-characterized bacterial genera
Brett Trost Monique Haakensen Vanessa Pittet Barry Ziola Anthony Kusalik 《BMC microbiology》2010,10(1):258
Background
The increasing availability of whole genome sequences allows the gene or protein content of different organisms to be compared, leading to burgeoning interest in the relatively new subfield of pan-genomics. However, while several studies have analyzed protein content relationships in specific groups of bacteria, there has yet to be a study that provides a general characterization of protein content relationships in a broad range of bacteria. 相似文献20.