共查询到20条相似文献,搜索用时 0 毫秒
1.
N. I. Shlyk 《Human physiology》2016,42(6):655-664
This article presents a new approach to planning and timely adjusting athletic trainings according to the data of the quick analysis of heart rate variability. It has been shown that individual types of regulation are different not only in the autonomic balance, but also in the degree of endurance of training and competition loads. 相似文献
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Background
The brightness of the probe spots on expression microarrays intends to measure the abundance of specific mRNA targets. Probes with runs of at least three guanines (G) in their sequence show abnormal high intensities which reflect rather probe effects than target concentrations. This G-bias requires correction prior to downstream expression analysis. 相似文献3.
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A new molecular-modeling methodology has been applied to explain enzymatic enantioselectivity in water. This methodology, which combines vacuum molecular mechanics and the continuum solvation method, should provide a more realistic view of the solvent-enzyme and solvent-substrate interactions than the heretofore used approaches involving the vacuum molecular mechanics only. The methodology described herein has been validated using the experimental data on alpha-chymotrypsin's enantioselectivity in the hydrolysis of four chiral substrates. The reasons why the vacuum molecular mechanics, although not taking hydration into account, still in most cases provide a satisfactory approximation of reality are discussed. 相似文献
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T. Patarinska D. Dochain S. N. Agathos L. Ganovski 《Bioprocess and biosystems engineering》2000,22(6):517-527
The problem of chemostat dynamics modelling for the purpose of control is considered. The "memory" of the culture is explicitly taken into account. Two possibilities for improving the quality of the proposed modelling approaches are discussed. A general model that accounts for the culture `memory' by means of different `memory' functions in the expressions of the specific growth rate and of the specific consumption rate and a polynomial function of the substrate concentration for the yield factor is proposed. The case where the maintenance energy is taken into account is also discussed. Two modifications of the general model (w-type and S-type) are presented. A zero-order `memory' function and a i-function with delay are applied in order to describe the `memory' effects. Continuous growth of the strain Saccharomyces cerevisiae on a glucose limited medium is considered as a case study. Detailed investigations of the variety of models, derived from the general model by applying different `memory' functions and different assumptions are carried out. The results are compared with those previously reported for the same process. It is shown that a significant improvement in predicting the substrate dynamics (not accompanied by any decrease in the quality of the model with respect to the biomass concentration) could be achieved, involving a first- or second-order polynomial function for the yield factor. It is also shown that the quality of the model mainly depends on the way that `memory' function is incorporated. The detailed investigations give priority to the w-type models. In this case past values of both biomass and substrate variables are considered. The time delay models with pure (constant) delay and those which account for the culture `memory' by zero-order `memory' function (adaptability parameter) are compared with respect to their utilization for the purpose of model-based control. 相似文献
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L M Romanov 《Genetika》1983,19(8):1322-1326
The connection of the histoincompatibility antigens, determined by the reaction in a mixed culture of lymphocytes of the pair of parents, with the litter of linear mice and live weight of cattle was studied. It was ascertained that the degree of the difference between mates for histocompatibility locus correlated with fruitfulness and productive qualities of the descendants. As a result, a greater quantity of descendants of animals, being more viable, are born. The descendants of the parents, having the high indexes of the reaction in the mixed culture of lymphocytes, are born larger and stronger and retain this advantage during succeeding life periods. The reaction in monozygotic twins has a minimum index. The index of the reaction increases when the relationship between individuals decreases. The method of mixed culture of lymphocytes can be used for prognosis of pairs' combination, for maintenance of the heterogeneity and for determination of the degree of relationship between animals. 相似文献
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A Reed-Frost model taking into account uncertainties in the diagnostic of the infection 总被引:1,自引:0,他引:1
In this paper, we model the epidemic course of a pathogen infection within a semi-closed group which generates clinical signals
which do not necessarily permit its ready and certain identification. Typical examples of such a pathogen are influenza-type
viruses. We allow for time-varying infectivity levels among individuals, and model the probability of infection per contact
as a function of the clinical signals. In order to accomplish this, we introduce a modified chain-binomial Reed-Frost model.
We obtain an expression for the basic reproduction ratio and determine conditions which guarantee that the epidemic does not
survive in the long-term. These conditions being functions of the signal’s distribution, they can be used to design and evaluate
interventions, such as treatment protocols. 相似文献
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Abakumov AI 《Zhurnal obshche? biologii》2000,61(2):145-156
The general approach for modelling of abundance dynamic of biological populations and communities is offered. The mechanisms of individual adaptation in changing environment are considered. The approach is detailed for population models without structure and with age structure. The property of solutions are investigated. As examples the author studies the concrete definitions of general models by analogy with models of Ricker and May. Theoretical analysis and calculations shows that survival of model population in extreme situation increases if adaptive behaviour is taking into account. 相似文献
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A mathematical model is proposed that takes into account the specific features of electronic excitation energy transfer between the molecular probes sorbed on a polymeric chain in a liquid solution. The kinetics of the process is described from the standpoint of the stochastic changes in macromolecular conformations. The results of numerical solution of the problem are described, as well as the analytical expressions obtained in the context of perturbation theory for a low transfer rate and/or fast conformational dynamics of the macrochain. A channel of nonlinear (with respect to excitation) deactivation resulting from binary annihilation of closely spaced excited centers is considered. Expressions for the efficient rate of mutual quenching and delayed annihilation fluorescence of the probe are obtained. The time dependences of characteristic luminescent signals and the parametric curves of relative fluorescence quantum yield are given. 相似文献
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MOTIVATION: In eukaryotes, rules regarding organization of cis-regulatory elements are complex. They sometimes govern multiple kinds of elements and positional restrictions on elements. RESULTS: We propose a method for detecting rules, by which the order of elements is restricted. The order restriction is expressed as element patterns. We extract all the element patterns that occur in promoter regions of at least the specified number of genes. Then, we find significant patterns based on the expression similarity of genes with promoter regions containing each of the extracted patterns. When we applied our method to Saccharomyces cerevisiae, we detected significant patterns overlooked by previous methods, thus demonstrating the utility of our method for analyses of eukaryotic gene regulation. We also suggest that several types of element organization exist: (i) those in which only the order of elements is important, (ii) order and distance both are important and (iii) only the combination of elements is important. AVAILABILITY: The program for extracting element patterns is available upon request. 相似文献
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A L Antelava 《Biulleten' eksperimental'no? biologii i meditsiny》1988,106(7):120-122
The method is suggested for the quantitative characteristics of dynamic vascular tone. It allows the determination of a degree of vascular vasoconstriction as a definite value--an index. This index is determined as real area of vascular cross-sections to their maximum possible area ratio with the inner elastic membrane fully straightened. The index determined in such a way permits to assess quantitatively the degree of vascular vasoconstriction, which is independent of the vascular diameter. 相似文献
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R V Petrov L V Koval'chuk N A Konstantinova A S Pavliuk E Iu Vel'tishcheva 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》1985,(3):61-67
The problem of correlation of the parameters of the immune system in the normal subjects and in patients with immunological diseases has been considered. The most informative relations have been determined and an attempt has been made to reveal common and specific signs of various immunological diseases. 相似文献
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Daniel Lambertz Isabelle Mora Jean-Francois Grosset Chantal Perot 《Journal of applied physiology》2003,95(1):64-72
Musculotendinous (MT) stiffness of the triceps surae (TS) muscle group was quantified in 28 prepubertal children (7-10 yr) by using quick-release movements at different levels of submaximal contractions. Surface electromyograms (EMG) of each part of the TS and of the tibialis anterior were also recorded. A stiffness index, defined as the slope of the angular stiffness-torque relationship (SIMT-Torque), was used to quantify changes in MT stiffness with age. Results showed a significant decrease in SIMT-Torque with age, ranging from 4.02 +/- 0.29 to 2.88 +/- 0.31 rad-1 for the youngest to the oldest children. Because an increase in stiffness with age was expected due to the maturation of elastic tissues, overactivation of the TS was suspected to contribute to the higher SIMT-Torque values found in the youngest children. TS EMG-torque analyses confirmed that neuromuscular efficiency was significantly lower for the 7- or 8-yr-old children compared with 10-yr-old children, notably due to a higher degree of tibialis anterior coactivation found in the youngest children. Thus the stiffness index originally defined as the slope of the angular stiffness-EMG relationship increased significantly with age toward adult values. The results underlined the necessity to take into account the capacities of muscle activation to quantify changes in elastic properties of muscles, when those capacities are suspected to be altered. 相似文献
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Binding of non-intercalating antibiotics to B-DNA: a theoretical study taking into account nucleic acid flexibility 总被引:5,自引:0,他引:5
A detailed theoretical study has been made for five antibiotics which all bind selectively to AT sequences in the minor groove of B-DNA: SN-18071, NSC-101327, distamycin-2, distamycin-3 and netropsin. The optimal complexes were found for systems in which the flexibility of DNA, as well as that of the antibiotics, was taken into account. Explicit, mobile counterions and a dielectric function modelling aqueous solution were also included. The binding geometries of the most strongly interacting antibiotics, distamycin-3 and netropsin, are compared in considerable detail and it is shown that notable differences exist between them. The results for netropsin are also discussed in the light of recent disagreements concerning its exact binding location within DNA. 相似文献
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Lahti L Elo LL Aittokallio T Kaski S 《IEEE/ACM transactions on computational biology and bioinformatics / IEEE, ACM》2011,8(1):217-225
Probe defects are a major source of noise in gene expression studies. While existing approaches detect noisy probes based on external information such as genomic alignments, we introduce and validate a targeted probabilistic method for analyzing probe reliability directly from expression data and independently of the noise source. This provides insights into the various sources of probe-level noise and gives tools to guide probe design. 相似文献