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Clerc I Polakowski N André-Arpin C Cook P Barbeau B Mesnard JM Lemasson I 《The Journal of biological chemistry》2008,283(35):23903-23913
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Acetylation of nucleosomal histones by p300 facilitates transcription from tax-responsive human T-cell leukemia virus type 1 chromatin template
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Lu H Pise-Masison CA Fletcher TM Schiltz RL Nagaich AK Radonovich M Hager G Cole PA Brady JN 《Molecular and cellular biology》2002,22(13):4450-4462
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Harrod R Kuo YL Tang Y Yao Y Vassilev A Nakatani Y Giam CZ 《The Journal of biological chemistry》2000,275(16):11852-11857
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p300/CBP/p53 interaction and regulation of the p53 response. 总被引:10,自引:0,他引:10
S R Grossman 《European journal of biochemistry》2001,268(10):2773-2778
Substantial evidence points to a critical role for the p300/CREB binding protein (CBP) coactivators in p53 responses to DNA damage. p300/CBP and the associated protein P/CAF bind to and acetylate p53 during the DNA damage response, and are needed for full p53 transactivation as well as downstream p53 effects of growth arrest and/or apoptosis. Beyond this simplistic model, p300/CBP appear to be complex integrators of signals that regulate p53, and biochemically, the multipartite p53/p300/CBP interaction is equally complex. Through physical interaction with p53, p300/CBP can both positively and negatively regulate p53 transactivation, as well as p53 protein turnover depending on cellular context and environmental stimuli, such as DNA damage. 相似文献
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