共查询到20条相似文献,搜索用时 31 毫秒
1.
2.
3.
4.
5.
6.
7.
8.
Makoto Koizumi Rika Koga Hitoshi Hotoda Kenji Momota Toshinori Ohmine Hidehiko Furukawa Toshinori Agatsuma Takashi Nishigaki Koji Abe Toshiyuki Kosaka Shinya Tsutsumi Junko Sone Masakatsu Kaneko Satoshi Kimura Kaoru Shimada 《Bioorganic & medicinal chemistry》1997,5(12):2235-2243
We have determined that hexadeoxyribonucleotides (5′TGGGAG3′), with modified aromatic groups such as a trityl group at the 5′-end, have anti-HIV-1 activity in vitro. The 6-mer bearing a 3,4-dibenzyloxybenzyl (3,4-DBB) group at the 5′-end had the most potent activity and the least cytotoxicity. When the 3′-end of the 5′-(3,4-DBB)-modified 6-mer was substituted with a 2-hydroxyethylphosphate, a 2-hydroxyethylthiophosphate, or a methylphosphate group at the 3′-end, anti-HIV-1 activity increased. Moreover, among various 3′- and 5′-end-modified 6-mers that were tested, the 6-mer (R-95288) bearing a 3,4-DBB group at the 5′-end and a 2-hydroxyethylphosphate group at the 3′-end was the most stable, when incubated with mouse, rat, or human plasma. Therefore, R-95288 was chosen as the best candidate for possible use in therapy on the basis of its anti-HIV-1 activity. 相似文献
9.
The novel mechanism of initiation of picornavirus RNA translation 总被引:74,自引:0,他引:74
Richard J. Jackson Michael T. Howell Ann Kaminski 《Trends in biochemical sciences》1990,15(12):477-483
The initiation of translation of picornaviral RNAs takes place by an unusual mechanism whereby ribosomes bind directly to an internal site rather than scan the RNA from the 5′-end. This internal entry mechanism requires a 450-nucleotide segment of the picornavirus 5′-untranslated region. The ribosome binds initially to a site at the 3′-end of this segment, and then may scan the RNA to reach the authentic initiation site. This novel mechanism may be of relevance to the translation of some cellular mRNAs. 相似文献
10.
11.
12.
13.
14.
15.
Enzymatic in vitro synthesis of globin genes. 总被引:74,自引:0,他引:74
16.
17.
18.
19.
20.