共查询到20条相似文献,搜索用时 15 毫秒
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Y Nasuhara I M Adcock M Catley P J Barnes R Newton 《The Journal of biological chemistry》1999,274(28):19965-19972
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Promoter occlusion during ribosomal RNA transcription 总被引:34,自引:0,他引:34
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Schmidt C Peng B Li Z Sclabas GM Fujioka S Niu J Schmidt-Supprian M Evans DB Abbruzzese JL Chiao PJ 《Molecular cell》2003,12(5):1287-1300
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The inhibitor of NF-kappaB (IkappaB) family of proteins is believed to regulate NF-kappaB activity by cytoplasmic sequestration. We show that in cells depleted of IkappaBalpha, IkappaBbeta and IkappaBepsilon proteins, a small fraction of p65 binds DNA and leads to constitutive activation of NF-kappaB target genes, even without stimulation, whereas most of the p65 remains cytoplasmic. These results indicate that although IkappaBalpha, IkappaBbeta and IkappaBepsilon proteins could be dispensable for cytoplasmic retention of NF-kappaB, they are essential for preventing NF-kappaB-dependent gene expression in the basal state. We also show that in the absence of IkappaBalpha, IkappaBbeta and IkappaBepsilon proteins, cytoplasmic retention of NF-kappaB by other cellular proteins renders the pathway unresponsive to activation. 相似文献
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