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Multiple mechanisms and functions of maf transcription factors in the regulation of tissue-specific genes 总被引:2,自引:0,他引:2
Kataoka K 《Journal of biochemistry》2007,141(6):775-781
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Kaneto H Matsuoka TA Nakatani Y Miyatsuka T Matsuhisa M Hori M Yamasaki Y 《The Journal of biological chemistry》2005,280(15):15047-15052
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The islet beta cell-enriched RIPE3b1/Maf transcription factor regulates pdx-1 expression 总被引:3,自引:0,他引:3
Samaras SE Zhao L Means A Henderson E Matsuoka TA Stein R 《The Journal of biological chemistry》2003,278(14):12263-12270
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Cooperativity of sequence elements mediates tissue specificity of the rat insulin II gene. 总被引:9,自引:5,他引:4
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The 5'-flanking region of the rat insulin II gene (-448 to +50) is sufficient for tissue-specific expression. To further determine the tissue-specific cis-acting element(s), important sequences defined by linker-scanning mutagenesis were placed upstream of a heterologous promoter and transfected into insulin-producing and -nonproducing cells. Rat insulin promoter element 3 (RIPE3), which spans from -125 to -86, was shown to confer beta-cell-specific expression in either orientation. However, two subregions of RIPE3, RIPE3a and RIPE3b (defined by linker-scanning mutations), displayed only marginal activities. These results suggest that the two subregions cooperate to confer tissue specificity, presumably via their cognate binding factors. 相似文献
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