Caméras hybrides TEMP-TDM et semi-quantification du I-FPCIT : évaluation de l’apport de la TDM

Objectives

Tomoscintigraphy of dopamine transporters with ¹²³I-FP-CIT is nowadays essential to visualise impairment of nigro-striatal system for the diagnosis of parkinsonism and for the differential diagnosis of dementia. With the development of hybrid cameras (SPECT-CT), the CT contribution in nuclear neurology needs to be assessed in diagnostic and semi-quantification performances. The main purpose of our study is to compare attenuation correction using CT to attenuation correction using the linear algorithm of Chang. SPECT-CT with parallel collimation results were also weighed against fan beam collimation and the contribution of partial volume effect correction was studied in secondary objective.

Materials and methods

We used a trilinear phantom to define spatial resolution and an anthropomorphic striatal phantom to quantify the activity in striatal cavities. We compared the impact of attenuation and scatter correction on spatial resolution and semi-quantification in striatum. We performed the partial volume effect correction on reconstructed images according to the method of Rousset.

Results

Attenuation correction by CT did not improve significantly spatial resolution compared to the algorithm of Chang. The semi-quantification of ¹²³I-FPCIT in striata was not significantly different according to the various CA, but was significantly improved with CT attenuation and scatter correction. Partial volume effect correction improved the quantification from 40 to 60% in the striatal structures, when the activity was superior in at least twice the background noise.

Conclusion

SPECT-CT hybrid cameras increase spatial resolution and improve semi-quantification of ¹²³I-FPCIT because of CT attenuation and scatter correction. Another use of CT is the possibility of calibrating anatomic segmentation of striata for partial volume effect correction. Partial volume effect correction improves quantification and is essential for early diagnosis of nigro-striatal disease.     

Morphologie, fonction et évolution de quelques grains de pollen normapolles du Crétacé supérieur

Upper Cretaceous pollen grains with a thick wall (exine) and sometimes protruding apertures, included in the Normapolles Pflug, are considered from a functional point of view. Because of the high development of compression-resistance features correlative with a high protection of the gametophyte, an entomophilic phase is supposed in the dissemination of some types, but anemophily appears to have been a developmental trend of apertural specialization for others. As these functional features are characteristic of the outer part of the wall (the sexine), the tetrahedral morphology of the inner part (the nexine) and the lack of evidence that it influenced the whole adaptive system suggest that angiospermic constraints have acted first at a pteridophytic stage.     

Perturbateurs endocriniens et écosystèmes

Hormonal imbalances, sexual changes and unusual behaviours are observed in wildlife. Some chemicals are implicated as endocrine disruptors (EDCs). Their dispersal into ecosphere allows them to reach biotopes isolated of emission sources and they accumulate in organisms and they cause alterations in biological functions (reprotoxicity, immunotoxicity, etc.). Beyond the individual, the community equilibrium is endangered with a potential impact on biodiversity. The organohalogen substances are historically concerned. Despite the prohibition of organochlorine pesticides and PCBs, they persist in aquatic and terrestrial habitats. But the “emerging substances” are also dangerous. Numerous examples of endocrine disruption in animal communities are described. The imposex in female of marine gastropods related to tributyltin (TBT) is one of the earliest known events. The feminization of fish in the estuary of the Seine, the hermaphroditism of some amphibians and the strange behaviour of birds, are famous facts. The cumulative effects are of concern to wild populations. These are mix of pollutants or the concomitancy of other global changes, the decline of polar bears or seals from the Baltic Sea proves it. In conclusion, endocrine disruption jeopardizes all natural biological systems and contributes in loss of biological diversity by reducing the number of sensitive species and making them vulnerable, considering the global extinction risk.     

Ulminium diluviale Unger : historique de la découverte et nouvelle étude

A fossil tree was discovered during the 16th century at Jáchymov (Bohemia). The wood was first named by Unger, in 1842, Ulminium diluviale. But it belongs to the Lauraceae family and Felix, in 1883, named it Laurinoxylon diluviale. The authors give the history and the geological setting of the area and describe the anatomy of the wood. The diagnosis of the genus Laurinoxylon Felix, 1883. is emended as follows: heteroxylous fossil wood with average sized solitary vessels or in radial groups; perforation plates simple and sometimes scalariform; intervascular pits alternate and moderately large; thyloses present. Paratracheal parenchyma. Uni to five seriate rays, slightly heterocellular and less than 1 mm high; ray-vessel pits large often stretched. Libriform or with radial pits fibres. Oil cells or mucilage (idioblasts) present. The diagnosis of the species Laurinoxylon diluviale (Unger) Felix, 1883. is also emended. Heteroxylous fossil wood with distinct growth rings; late wood poorly developed with vessels of diameter distinctly smaller as compared to the early wood and with smaller diameter fibres. Diffuse to semiporous vessels, solitary or in radial groups of two to seven , nine to 16 pores/mm²; tangential diameter 100 to 154 μm in early wood and 44 to 72 μm in late wood; vessel length 300 to 550 μm; perforation plates simple and scalariforme (6–12 bars); intervascular pits alternate, rounded (diameter 7–10 μm) or elliptic (long axes × short axes: 10–15 μm × 7–10 μm); thylosis present. Paratracheal parenchyma in more or less complete rows (1–2 cells wide) around the vessels. Heterocellular rays (1–(3) rows of upright cells), of one to five, more frequently three to four cells wide (80%); two to 36 cells high (60 to 820 μm); six to seven rays per tangential millimetre; vessels-rays pits sometimes large, stretched horizontally to vertically. Fibres of 15 to 25 μm in diameter; cell walls of 2–3 μm thick; pits not seen. Oil cells (idioblasts) at the ray margins; 27–60 μm in tangential diameter; 50–80 μm in radial diameter; 72–140 μm high; density of zero to 18 per transversal square millimetres depending on the observed area.     

Distribution et écologie des associations d’ostracodes récents de l’estuaire de Tahadart (Maroc Nord-Occidental)

Forty-five ostracod species were identified for the first time in the Tahadart estuary (NW Morocco). They can be grouped into five different ecological assemblages, which characterise four estuarine ecozones. A first ecozone occurs in temporary waters located between the tidal channels of the inner estuary and it is characterised by ostracod species typical of fresh to brackish waters. In the main estuary area, the ostracod fauna is dominated by clearly euryhaline species that account for nearly 70% of the entire fauna. The relative abundance of the different assemblages allows us to subdivide the estuarine environment along a longitudinal profile into mouth, outer and inner estuary. The estuary's mouth displays the highest values of marine euhaline, phytal and periphytal as well as ubiquitous species and the lowest values of very euryhaline species; the latter are the only species present in the inner estuary. The outer estuary exhibits intermediate percentages of the different ecological assemblages. This distribution, characterized by the absence of limnic species, points to the influence of marine waters in an open estuary with a low fresh water input. In the estuary's mouth, as well as in the outer estuary, where the slikke and schorre are well developed, the distance to the emersion line is underlined by the lower occurrence of marine and ubiquitous species and the higher occurrence of the very euryhaline ones. The Tahadart estuary displays a moderate to high ostracod diversity with distinct differences among the ecological zones. The stress of this environment is highlighted by the low diversity characteristics of extreme environments, alike in the inner estuary and in some areas located far from the emersion level. The relative position with respect to the emersion line, as well as the presence of gross detritic sediments and vegetation, appear to be of importance for the good development of the ostracods.     

Les premiers Européens et la dynamique des interactions avec leur environnement : comportement écologique et niveau de cognition

Men and Carnivores used to live very closely during the Lower Pleistocene as show the assemblages. This allows us to reconstruct their behaviors and to bring up the idea that they used to share an ecological niche. It is also possible to understand the evolution of their behaviors, as regards the food supply, and the way they used to live in the sites. The first Europeans had a great capacity for adaptation, as well as a certain vulnerability, just like the Carnivores. The acquisitions of specialized technics are likely to have reduced this capacity for adaptation, as they got free from their opportunistic predator position.     

Les premières étapes de la colonisation de l’Europe et l’arrivée de l’Homme sur les rives de la Méditerranée

Over recent years, many discoveries have renewed our knowledge about the oldest stone industries and also about the behaviour and lifestyle of the hominids that made them, not only in East Africa, but also in the Near East, in Trans Caucasia and in southern Europe. If the first tools making hominids appear in East Africa as early as 2.55 million years ago, they are present in the Levant a little over 2 million years ago, as early as 1.81 million years ago at the gates of Europe in Trans-Caucasia, and a little over 1.4 million years ago on the Mediterranean coasts of Europe.     

Tomographie par émission de positons au F-fluorodeoxyglucose dans la mise en évidence de la maladie veineuse thromboembolique

Purpose

Association of venous thromboembolism (VTE) and inflammation reported in the literature may allow the use of FDG PET/CT in the detection of thrombotic process. Published studies remain limited and contradictory. The aim was, therefore, to evaluate the performance of FDG PET/CT for the detection of VTE.

Patients and methods

Patients included in a prospective study evaluating FDG PET/CT for the detection of malignancy in patients with idiopathic VTE were analysed (MVTEP, PHRC 2008). PET/CT images were interpreted initially without and then retrospectively with knowledge of VTE locations.

Results

Hundred and fourteen patients were included in MVTEP study from March 13th 2009 to July 1st 2010. Forty-six patients (median age: 74 years [20-87], 27 males, 19 females) were analysed. No abnormal uptake was initially reported in pulmonary vessels. The retrospective analysis of pulmonary embolism locations did not demonstrate any significant difference in FDG uptake between embolic sites and controlateral vessels (P = 0.883). Initial analysis of lower limbs vessels demonstrated sensitivity and specificity of PET/CT for deep venous thrombosis (DVT) diagnosis of 15 and 99%. The metabolic activity of DVT was significantly higher than the activity of controlateral vessels (P < 0.005) but without showing any significant SUV threshold for DVT diagnosis.

Conclusion

In conclusion, there is insufficient evidence to suggest that FDG PET/CT could be accurate in detection of VTE. These results need to be completed in a larger study with shorter delay between VTE and FDG PET/CT.     

Une nouvelle approche pour évaluer l'état de conservation de l'os et du collagène pour les mesures isotopiques (datation au radiocarbone, isotopes stables du carbone et de l'azote)

Measuring the amounts of nitrogen and carbon in small quantities of ancient bones before radiocarbon dating using elemental analysis is a way to quantify the amount of preserved collagen and the quantity of exogenous contaminating carbon. Such a measurement can be performed on a large number of samples and allows to sort out the specimens with the best preserved collagen, those with the most carbon contamination, and eventually to infer relationships between burial conditions and collagen preservation. This approach is most interesting as a preliminary method to use before attempting radiocarbon dating using accelerator mass spectrometry of bone collagen.     

Biochronologie et corrélation des bassins néogènes du Couloir sud-rifain (Maroc) fondées sur les évènements de foraminifères planctoniques et de nannofossiles calcaires

Qualitative and quantitative analyses of planktonic foraminifera (completed by calcareous nannofossils in some localities) from 8 sections and boreholes located in 7 Neogene basins of the South Rifian Corridor (Morocco) enable us to identify 16 bioevents calibrated with the geomagnetic polarity time scale. These events are useful for (1) assigning the sediments to the Tortonian (bioevents 1 to 7), the Messinian (bioevents 9 to 14, the event 8 indicates the Tortonian/Messinian boundary), the Early Pliocene (bioevent 15) and the Middle Pliocene (bioevent 16), (2) establishing high resolution correlations between the sections and boreholes studied herein, (3) locating the South Rifian Corridor sections and boreholes within the framework of biostratigraphic events recognized during the latest ten years in time-equivalent Atlantic and Mediterranean sequences, and (4) estimating the variation of sedimentation rates in the studied basins. With respect to Morocco, previous detailed studies concerned only the Rabat area (Bou Regreg valley) and Guercif basin. Our results extend correlations to the other basins of the South Rifian Corridor, a key area to understand connections between the Atlantic Ocean and the Mediterranean Sea at the end of the Miocene.     

Approche paléontologique de l’évolution du langage : un état des lieux

One of the most influential paleoanthropological approaches to the question of language origins has been the attempt to reconstruct the supralaryngeal vocal tract (SVT) in fossil humans. In particular, the low placement of the larynx was considered to be a uniquely human feature and was interpreted as a specific adaptation to produce human speech. Nevertheless, based on the anatomy of the basicranium and the hyoid bone, various researchers reached different conclusions regarding the placement of the larynx in human fossils, especially in Neandertals. Further, the recent finding of a low placement of the larynx in chimpanzees, calls into question the basic premise on which much of this research has been based. To overcome this, we have proposed and developed a new line of research into the question of speech capabilities in fossil specimens which is focused not on the ability to produce the sounds of spoken language, but on the capacity to perceive them. The modern human auditory pattern is unique among primates in showing a relatively heightened sensitivity to the midrange frequencies between 2-4 kHz, a frequency range which coincides with that of spoken language. Our analysis shows that the preserved skeletal anatomy of the outer and middle ear in the Middle Pleistocene hominids from the site of the Sima de los Huesos is compatible with human-like auditory capacities, and is clearly different from chimpanzees in the midrange frequencies. These results strongly suggest that the anatomical structures which support the modern hum and pattern of intraspecific communication were already present in these human ancestors. Further, the presence of a common condition in both the modern human and Neandertal evolutionary lineages suggests this represents an ancient adaptation within the genus Homo.     

Les pistes dinosauroïdes du Trias moyen français : interprétation et réévaluation de la nomenclature

Numerous dinosauroid footprints which showing sometimes manus imprint mark were gathered, since 1960, from the lower sandstones Triassic formations of the eastern border of the Massif Central (France). Tracks bearing levels are dated from palynological, micropalaeontological and palichnological data. They belong to the period upper Anisian-lower Ladinian. The paleontological results show bipedal digitigrade reptiles with erected, long hind limbs, having also pentadactyl mani and (II-IV) tridactyl feet. The osteological feet inferred structure is like that of Ceratosauria of Late Triassic age. The skeletons of first Dinosauria, diversified already well, are known in summit Ladinian and lower Carnien and those of their ancestors, Dinosauriformes, in Ladinian. And, for this reason, the aniso-ladinian dinosauroid footprints are ascribed to these last animals which thus appeared earlier, to Anisan even to late Olenekian. The chirotheroid hands show a “pseudosuchian” origin which possibly took place during the late Olenekian; feet modifications of these Crurotarsi being characterized by I and V digits reduction and a meso-tarsal joint. The Anisian-Ladinian dinosauroid footprints are ascribed to the ichnospecies Coelurosaurichnus perriauxi and Anchisauripus bibractensis. The discriminant analysis computed from these latter ichnospecies, and others from the German Triassic, French and USA Hettangian indicate that C. perriauxi and A. bibractensis can not be included into Grallator sensu Lull, 1953 or Coelurosaurichnus of Franconie. By this way, these taxa are well original and till now, there was no reason to change their nomenclature. Nevertheless because the numerous changes of Grallator which gathers now, most of dinosauroid footprints, it could be possible to include them into Grallator for the feet and into Atreipus when the manus trace is connected with the foot.