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1.
摘要 目的:研究应用剪切波弹性成像技术对脑卒中偏瘫患者肌张力、肌硬度进行评估的临床价值。方法:选取2019年3月到2021年2月在我院进行治疗的79例脑卒中偏瘫患者作为研究对象,应用超声仪检测所有研究对象健康侧(健侧)和患病侧(患侧)肱二头肌、肱肌和肱桡肌放松位和拉伸位下杨氏模量值,进行对比分析。结果:在放松位下,脑卒中偏瘫患者患侧肱二头肌和肱桡肌杨氏模量与健康侧肌肉相比无显著差异(P>0.05),而患侧肱肌杨氏模量显著低于健侧(P<0.05)。在拉伸位下,脑卒中偏瘫患者患侧肱二头肌、肱肌和肱桡肌杨氏模量均显著高于健康侧肌肉(P<0.05);脑卒中偏瘫患者放松位与拉伸位肱二头肌、肱肌和肱桡肌杨氏模量差值也均显著高于健康侧肌肉(P<0.05)。此外,不同改良Ashworth肌张力分级的脑卒中偏瘫患者患侧肱二头肌、肱肌和肱桡肌杨氏模量均存在显著差异(P<0.05),并且患侧肱二头肌、肱肌和肱桡肌杨氏模量值随改良Ashworth肌张力分级升高而增加。结论:剪切波弹性成像技术可用于评估脑卒中偏瘫患者肌张力、肌硬度,以指导临床康复。  相似文献   

2.
Abstract

The neural substrates of tactile roughness perception have been investigated by many neuroimaging studies, while relatively little effort has been devoted to the investigation of neural representations of visually perceived roughness. In this human fMRI study, we looked for neural activity patterns that could be attributed to five different roughness intensity levels when the stimuli were perceived visually, i.e., in absence of any tactile sensation. During functional image acquisition, participants viewed video clips displaying a right index fingertip actively exploring the sandpapers that had been used for the behavioural experiment. A whole brain multivariate pattern analysis found four brain regions in which visual roughness intensities could be decoded: the bilateral posterior parietal cortex (PPC), the primary somatosensory cortex (S1) extending to the primary motor cortex (M1) in the right hemisphere, and the inferior occipital gyrus (IOG). In a follow-up analysis, we tested for correlations between the decoding accuracies and the tactile roughness discriminability obtained from a preceding behavioural experiment. We could not find any correlation between both although, during scanning, participants were asked to recall the tactilely perceived roughness of the sandpapers. We presume that a better paradigm is needed to reveal any potential visuo-tactile convergence. However, the present study identified brain regions that may subserve the discrimination of different intensities of visual roughness. This finding may contribute to elucidate the neural mechanisms related to the visual roughness perception in the human brain.  相似文献   

3.
Abstract

A novel simulation interface is being developed as an educational tool to help students better understand fundamentals of materials science. This interface makes use of virtual reality (VR) technology consisting of PC-based graphics and a force-feedback haptic device. Visualization of atomistic processes with simultaneous tactile sensation via the haptic provides a powerful method for understanding complex phenomena that are otherwise difficult to comprehend. Modules are described that allow students to interactively explore interatomic bonding and single-atom diffusion through materials.  相似文献   

4.
Szechuan pepper, a widely used ingredient in the cuisine of many Asian countries, is known for the tingling sensation it induces on the tongue and lips. While the molecular mechanism by which Szechuan pepper activates tactile afferent fibres has been clarified, the tingling sensation itself has been less studied, and it remains unclear which fibres are responsible. We investigated the somatosensory perception of tingling in humans to identify the characteristic temporal frequency and compare this to the established selectivity of tactile afferents. Szechuan pepper was applied to the lower lip of participants. Participants judged the frequency of the tingling sensation on the lips by comparing this with the frequencies of mechanical vibrations applied to their right index finger. The perceived frequency of the tingling was consistently at around 50 Hz, corresponding to the range of tactile RA1 afferent fibres. Furthermore, adaptation of the RA1 channel by prolonged mechanical vibration reliably reduced the tingling frequency induced by Szechuan pepper, confirming that the frequency-specific tactile channel is shared between Szechuan pepper and mechanical vibration. Combining information about molecular reactions at peripheral receptors with quantitative psychophysical measurement may provide a unique method for characterizing unusual experiences by decomposing them into identifiable minimal units of sensation.  相似文献   

5.
Objective—The primary nerves innervating the female genitalia are the dorsal nerve of the clitoris (DNC) and the perineal nerve, which innervate the clitoris and the external genitalia/distal vagina, respectively. We describe two novel electrodiagnostic techniques for evaluating the integrity of these female genital somatosensory pathways.

Subjects and methods—Seventy-seven healthy women (mean age 29.3 years) were enrolled for this study. We performed DNC somatosensory evoked potentials (SEPs), stimulating through self-adhesive disk electrodes on either side of the clitoris. Perineal nerve SEPs were evoked through a vaginal probe. Cortical responses were measured through cup electrodes affixed to the scalp at Cpz and Fpz. Stimulus parameters were duration 0.1?ms, frequency 4.1?Hz, filters 5–5,000?Hz, at three times sensory threshold.

Results—DNC and perineal nerve SEPs from both the right and left sides were reproducible and easily discerned. The mean P1 latencies were: right DNC 39.4?ms (SD 2.8?ms), left DNC 39.3?ms (SD 3.3?ms), right perineal nerve 37.8?ms (SD 3.4?ms), left perineal nerve 37.6?ms (SD 3.1?ms). We recorded SEP responses from 90 to 92% of subjects for the DNC, and 69% for the perineal nerve.

Conclusions—We are able to evoke somatosensory potentials from the four primary somatic nerves that mediate female genital cutaneous sensation. In healthy subjects, the DNC responses are robust and maintain laterality. The perineal nerve responses are less consistently obtained, but when recorded, are easily discerned. These preliminary data provide a foundation from which to study female genital innervation, particularly as it applies to sexual function.  相似文献   

6.
BackgroundReduced hippocampal volume in schizophrenia is a well-replicated finding. New imaging techniques allow delineation of hippocampal subfield volumes. Studies including predominantly chronic patients demonstrate differences between subfields in sensitivity to illness, and in associations with clinical features. We carried out a cross-sectional and longitudinal study of first episode, sub-chronic, and chronic patients, using an imaging strategy that allows for the assessment of multiple hippocampal subfields.MethodsHippocampal subfield volumes were measured in 34 patients with schizophrenia (19 first episode, 6 sub-chronic, 9 chronic) and 15 healthy comparison participants. A subset of 10 first episode and 12 healthy participants were rescanned after six months.ResultsTotal left hippocampal volume was smaller in sub-chronic (p = 0.04, effect size 1.12) and chronic (p = 0.009, effect size 1.42) patients compared with healthy volunteers. The CA2-3 subfield volume of chronic patients was significantly decreased (p = 0.009, effect size 1.42) compared to healthy volunteers. The CA4-DG volume was significantly reduced in all three patient groups compared to healthy group (all p < 0.005). The two affected subfield volumes were inversely correlated with severity of negative symptoms (p < 0.05). There was a small, but statistically significant decline in left CA4-DG volume over the first six months of illness (p = 0.01).ConclusionsImaging strategies defining the subfields of the hippocampus may be informative in linking symptoms and structural abnormalities, and in understanding more about progression during the early phases of illness in schizophrenia.  相似文献   

7.
摘要 目的:探讨不同听力曲线分型突发性耳聋患者听阈水平及临床特征分析。方法:前瞻性选取我院2019年10月至2022年10月我院收治的80例突发性耳聋患者作为研究对象。采集患者临床特征信息。检测所有患者听阈水平。采用秩和检验进行多组间差异分析;采用Spearman检验进行相关性分析;采用多元线性回归模型进行回归分析。结果:平坦下降组、低频下降组、高频下降组和全聋组在侧别、性别、糖尿病、耳鸣、眩晕、耳闷胀感亚组间差异显著(P<0.05),而在年龄、高血压和脑梗塞亚组间无显著差异(P>0.05);平坦下降组、低频下降组、高频下降组和全聋组在极重度、重度、中度、轻度、正常亚组间差异显著(P<0.05);突发性耳聋患者听力曲线分型与侧别、性别、糖尿病、耳鸣眩晕、耳闷胀感、听阈水平密切相关(P<0.05),而与年龄、高血压、脑梗塞无关(P>0.05);多元线性回归结果显示,耳鸣、眩晕、耳闷胀感、听阈水平、侧别是影响突发性耳聋患者听力曲线分型的独立危险因素(P<0.05)。结论:突发性耳聋不同听力曲线分型患者间存在临床特征及听阈水平的差异,临床可依据患者独特疾病特征构建精准的治疗策略进行干预。  相似文献   

8.
目的:评估芪菊袋泡茶对功能性鼻内镜术(FESS)术后的临床疗效。方法:采用随机数字表法将纳入观察的FESS术后患者分为两组,对照组为常规处理,治疗组在常规处理的基础上给予芪菊袋泡茶雾化吸入及饮用:术后6h开始予芪菊袋泡茶治疗,以芪菊袋泡茶一袋配30 mL饮用水,作雾化吸入,另予一袋配100 mL饮用水泡服,每天2次,雾化联合饮用共1周。雾化疗程结束后,则以每次2袋,每天2次泡服,再饮用2周,并随访12周。比较两组间鼻窦炎相关症状(包括鼻塞、头痛、面痛、嗅觉障碍、鼻涕)评分、鼻腔粘膜改变和术腔上皮化程度、术后咽喉部症状(包括咽痛、异物感、排痰、咳嗽)评分。结果:术后2、4、8、12周,治疗组鼻窦炎相关症状总评分与对照组比较差异有统计学意义(P0.05);治疗组在术后4、8、12周鼻腔粘膜评分、上皮化程度较对照组显著改善,差异有统计学意义(P0.05);治疗组在术后1d、3d咽喉部症状总评分、咽痛和异物感症状评分显著较对照组改善,差异有统计学意义(P0.05)。结论:芪菊袋泡茶在慢性鼻窦炎伴鼻息肉FESS术后能取得良好的临床疗效,明显改善术后症状,值得临床推广。  相似文献   

9.
The effects of skin indentation depth and rate on threshold and suprathreshold tactile sensations were investigated. Indentation rates between 0.3 and 10 mm/sec had little effect on the absolute tactile thresholds measured in terms of indentation depth. Slower rates resulted in increased absolute thresholds.

Estimates of the growth in intensity of tactile sensations were made as functions of indentation depth and rate. The fastest rate used (10 mm/sec), for a given depth of indentation, produced the most intense sensation; the slowest (0.1 mm/sec), the least intense sensation. The tactile sensation magnitude estimates, with rate as the parameter, could be described by power functions. At the slowest indentation rate the exponent of the function was 1.36. At faster indentation rates (0.4, 1.0, and 10 mm/sec), two functions of markedly different slopes were required to describe the estimates. The exponents of the power functions were between 0.38 and 0.49 for indentation depths up to about 0.9 mm, and between 1.07 and 1.43 for deeper indentation depths.  相似文献   

10.
摘要 目的:探讨MOTOmed下肢智能运动训练联合运动想象疗法对脑卒中偏瘫患者下肢功能、步行能力和躯干屈伸肌群肌力的影响。方法:148例脑卒中偏瘫患者来源于我院2019年5月~2021年5月期间我院接收的患者,根据随机数字表法分为对照组(n=74,常规康复训练的基础上结合MOTOmed下肢智能运动训练)和研究组(n=74,对照组的基础上结合运动想象疗法)。两组均干预12周。对比两组下肢功能、步行能力和躯干屈伸肌群肌力变化。结果:两组干预12周后Fugl-Meyer运动功能量表(FMA)、Barthel指数(BI)、功能性步行能力分级量表(FAC)评分升高,且研究组高于对照组(P<0.05)。两组干预12周后步频、步速、跨步长比率升高,且研究组高于对照组(P<0.05)。两组干预12周后健侧腹直肌、竖脊肌表面肌电信号的均方根值未见明显变化,且组间同时点对比无差异(P>0.05)。两组干预12周后患侧腹直肌、竖脊肌表面肌电信号的均方根值升高,且研究组高于对照组(P<0.05)。结论:脑卒中偏瘫患者在MOTOmed下肢智能运动训练的基础上进行运动想象疗法,可促进下肢功能改善,提高步行能力,同时还可改善患侧躯干屈伸肌群肌力。  相似文献   

11.
Sensation is commonly impaired immediately post-stroke but little is known about the long-term changes in cutaneous sensation that have the capacity to adversely impact independence and motor-function. We investigated cutaneous sensory thresholds across the hand in the chronic post-stroke period. Cutaneous sensation was assessed in 42 community-dwelling stroke patients and compared to 36 healthy subjects. Sensation was tested with calibrated monofilaments at 6 sites on the hand that covered the median, ulnar and radial innervation territories and included both glabrous (hairless) and hairy skin. The motor-function of stroke patients was assessed with the Wolf Motor Function Test and the upper-limb motor Fugl-Meyer Assessment. Impaired cutaneous sensation was defined as monofilament thresholds >3 SD above the mean of healthy subjects and good sensation was ≤3 SD. Cutaneous sensation was impaired for 33% of patients and was 40–84% worse on the more-affected side compared to healthy subjects depending on the site (p<0.05). When the stroke patient data were pooled cutaneous sensation fell within the healthy range, although ∼1/3 of patients were classified with impaired sensation. Classification by motor-function revealed low levels of impaired sensation. The magnitude of sensory loss was only apparent when the sensory-function of stroke patients was classified as good or impaired. Sensation was most impaired on the dorsum of the hand where age-related changes in monofilament thresholds are minimal in healthy subjects. Although patients with both high and low motor-function had poor cutaneous sensation, overall patients with low motor-function had poorer cutaneous sensation than those with higher motor-function, and relationships were found between motor impairments and sensation at the fingertip and palm. These results emphasize the importance of identifying the presence and magnitude of cutaneous sensory impairments in the chronic period after stroke.  相似文献   

12.
Uropathogenic Escherichia coli (UPEC) are pathogens that play an important role in urinary tract infections and bacterial prostatitis1. We have recently shown that UPEC have an important role in the initiation of chronic pelvic pain2, a feature of Chronic prostatitis/Chronic pelvic pain syndrome (CP/CPPS)3,4. Infection of the prostate by clinically relevant UPEC can initiate and establish chronic pain through mechanisms that may involve tissue damage and the initiation of mechanisms of autoimmunity5.A challenge to understanding the pathogenesis of UPEC in the prostate is the relative inaccessibility of the prostate gland to manipulation. We utilized a previously described intraurethral infection method6 to deliver a clinical strain of UPEC into male mice thereby establishing an ascending infection of the prostate. Here, we describe our protocols for standardizing the bacterial inoculum7 as well as the procedure for catheterizing anesthetized male mice for instillation of bacteria.CP/CPPS is primarily characterized by the presence of tactile allodynia4. Behavior testing was based on the concept of cutaneous hyperalgesia resulting from referred visceral pain8-10. An irritable focus in visceral tissues reduces cutaneous pain thresholds allowing for an exaggerated response to normally non-painful stimuli (allodynia). Application of normal force to the skin result in abnormal responses that tend to increase with the intensity of the underlying visceral pain. We describe methodology in NOD/ShiLtJ mice that utilize von Frey fibers to quantify tactile allodynia over time in response to a single infection with UPEC bacteria.  相似文献   

13.
Background aimsThe purpose of this study was to observe the clinical effect and safety of umbilical cord mesenchymal stem cells (UC-MSCs) in treating spinal cord injury (SCI) by intrathecal injection.MethodsFrom January 2008 to October 2010, we treated 22 patients with SCI with UC-MSCs by intrathecal injection; dosage was 1 × 106 cells/kg body weight once a week given four times as a course. Four patients received two courses, one patient received three courses and all other patients received one course. American Spinal Injury Association scoring system and International Association of Neurorestoratology Spinal Cord Injury Functional Rating Scale were used to evaluate neural function and ability to perform activities of daily living.ResultsTreatment was effective in 13 of 22 patients; nine patients had no response. Among patients with incomplete SCI, the response to treatment was 81.25%; there was no response to treatment among six patients with complete SCI. Five patients with a response to treatment received two to three courses of therapy, and effects in these patients were further enhanced. In most patients in whom treatment was effective, motor or sensory functions, or both, were improved, and bowel and bladder control ability was improved. In 22 patients 1 month after therapy, algesia, tactile sensation, motion and activity of daily living scale were significantly improved (P < 0.01). During therapy, common adverse effects were headache (one case) and low back pain (one cases); these disappeared within 1–3 days. No treatment-related adverse events occurred during a follow-up period ranging from 3 months to 3 years.ConclusionsUC-MSC therapy by intrathecal injection is safe and can improve neurologic function and quality of life in most patients with incomplete SCI.  相似文献   

14.
ObjectiveThis study used con-beam computed tomography (CBCT) to investigate the prevalence and severity of alveolar bone loss in middle-aged (40–59 years) Chinese with chronic periodontitis.ResultsThe study revealed that 40–59 year old patients with chronic periodontitis had severe bone loss. At 5,286 sites (34.7%), alveolar bone loss was mild; severe alveolar bone loss was found at 5,978 sites (39.2%). A comparison of bone loss in different jaws revealed that the area with the highest degree of bone loss was on the lingual side of the maxillary molar (56.3 ± 7.2%), and that the area with the lowest degree was primarily on the lingual side of the mandibular canine (27.5 ± 6.3%). There was a lower degree of alveolar bone loss in males than females. Differences were observed when comparing the incidence of bone loss between males and females (P < 0.05). Menopause in females and smoking in both genders may affect the level of bone loss. Male smokers experienced a greater degree of bone loss (41.67 ± 5.76%) than male non-smokers (32.95 ± 4.31%). A 42.23 ± 6.34% bone loss was found in menopausal females versus 31.35 ± 3.62% in non-menopausal females.ConclusionsThe study revealed that different sites and teeth exhibited a diverse degree of bone loss. In middle-aged patients with chronic periodontitis, the highest degrees of bone loss in the incisors, premolars, and molars were on the lingual side, mesial side and lingual side, respectively. Menopause in females and smoking may affect the level of bone loss.  相似文献   

15.
目的:探讨单向纳入式人工胃底活瓣用于食管-胃胸内吻合抗返流患者的临床效果。方法:选择2017年3月-2018年3月入院治疗的食管中下段癌根治术患者70例,所有患者均在腹腔镜下完成全胸腹腔镜下食管-胃胸内吻合手术,术后采用胃肠吻合器完成食管胃右胸内吻合完成消化道重建。根据抗返流方法分为对照组(n=35例)和观察组(n=35例)。对照组术后包埋吻合口,观察组术后采用单向纳入式人工胃底活瓣,两组治疗完毕后对患者效果进行评估。记录并比较两组治疗后痊愈、全身衰竭死亡、吻合口瘘、返酸及吐苦水返流症状、烧心感的发生率;采用WHOQol-BREF生活量表对两组治疗前、治疗后生活质量进行比较。结果:观察组治疗后痊愈率显著高于对照组(71.43%vs. 42.86%,P0.05),全身衰竭死亡、吻合口瘘、返酸及吐苦水返流症状、烧心感发生率均明显低于对照组(P0.05)。两组治疗后生理健康、心理状态、社会关系、周围环境及独立能力评分均显著高于治疗前(P0.05),且观察组治疗后生理健康、心理状态、社会关系、周围环境及独立能力评分均高于对照组(P0.05)。结论:单向纳入式人工胃底活瓣用于食管中下段癌根治术患者能降低返流症状的发生率,能提高患者生活质量。  相似文献   

16.
BackgroundAround 30% world population affected by acute and chronic pain due to inflammation and accidental injuries. Pain is a uncomfortable sensation and it reduce the patients’ life quality.ObjectiveThe present exploration focuses to explore the beneficial effects of butein on the different chemical and thermal-provoked nociceptive and inflammatory mice models.MethodologyThe nociception was induced to the Swiss mice using different chemical (formalin, acetic acid, glutamate, and capsaicin) and thermal (hot plate and tail immersion) methods. the mice were supplemented with 10, 15, and 20 mg/kg of butein and respective standard drugs like morphine, diclofenac sodium, and dexamethasone. The anti-inflammatory effects of butein was studied using carrageenan-provoked inflammation in mice.ResultsThe present findings clearly demonstrated that the butein was substantially lessened the different thermal and chemical provoked nociception in mice. The carrageenan-triggered paw edema and inflammatory cell infiltrations were appreciably suppressed by the butein treatment. The TNF-α, IL-1β, and IL-6 levels in the carrageenan-induced mice were effectively depleted by the butein.ConclusionAltogether, the present findings evidenced the potent antinociceptive and anti-inflammatory properties of the butein in different nociceptive mice models.  相似文献   

17.
Tactile stimulation of an insect's abdomen evokes various behaviors including grooming and vigorous escape responses. We tested a sample of 37 tactile-sensitive abdominal interneurons for various morphological and physiological characteristics, including their ability to excite thoracic interneurons that are known to integrate wind information conducted by giant interneurons in the classical escape response. The results suggest that abdominal tactile-sensitive interneurons are heterogeneous both in anatomical and physiological properties. In general, these cells are very small interganglionic interneurons that respond to tactile stimulation at more than one abdominal segment. However, the larger population contained virtually all types of cells. Some projected anteriorly, others posteriorly, and still others projected in both directions. For most cells, the soma was on the side opposite to their axons, but in 24% of the cells it was on the same side. Patterns of dendritic arbors also varied among cells. However, tactile sensitivity was in general consistent with the morphological bias noted in dendritic branch patterns. We were able to document the existence of tactile abdominal interneurons that connect directly to thoracic interneurons involved in escape (TIAs). However, instances of demonstrated connectivity were rare. One cell that did show connectivity (AI652) was characterized in detail, and its properties were appropriate for conducting tactile signals in a directional escape system. The dendritic arbors were biased to the side that was ipsilateral to the cell's soma and axon. As a result, this cell's abdominal inputs and thoracic outputs are on the same side. This pattern is appropriate for generating the sensory fields recorded previously in TIAs. Its axon was located in the ventral median tract, which should bring it close to the integrating region of the TIAs. © 1998 John Wiley & Sons, Inc. J Neurobiol 34: 227–241, 1998  相似文献   

18.
MethodsWe included all consecutive first-ever ischemic stroke patients, without hippocampal strokes or recurrent stroke/TIA, aged 18–50 years, admitted to our academic hospital between 1980 and 2010. One hundred and forty-six patients underwent T1 MPRAGE, DTI scanning and completed the Rey Auditory Verbal Learning Test and were compared with 84 stroke-free controls. After manual correction of hippocampal automatic segmentation, we calculated mean hippocampal fractional anisotropy (FA) and diffusivity (MD).ResultsOn average 10 years after ischemic stroke, lesion volume was associated with lower ipsilateral hippocampal integrity (p<0.05), independent of hippocampal volume. In patients with a normal ipsilateral hippocampal volume (volume is less than or equal to 1.5 SD below the mean volume of controls) significant differences in ipsilateral hippocampal MD were observed (p<0.0001). However, patients with a normal hippocampal volume and high hippocampal MD did not show a worse memory performance compared with patients with a normal volume and low hippocampal MD (p>0.05).ConclusionsPatients with average ipsilateral hippocampal volume could already have lower ipsilateral hippocampal integrity, although at present with no attendant worse memory performance compared with patients with high hippocampal integrity. Longitudinal studies are needed to investigate whether a low hippocampal integrity after stroke might lead to exacerbated memory decline with increasing age.  相似文献   

19.
Elicited potentials of the sensorimotor cortex were investigated in chronic experiments before and after unilateral injury to the spinocervical tract at the C3 level. Such injury led to a considerable disturbance of tactile and proprioceptive reactions but did not lower the amplitude of potentials elicited in the cerebral cortex by irritation of a limb on the injured side. On the intact side, there was an increase in the amplitude of the early response components to irritation of the extremity on this side. In 1–2 months after the operation proprioceptive sensitivity and motor activity had returned to normal, but the reactions to tactile irritation failed to reappear. Apparently the presence of a high level of afferent input into the cerebral cortex is insufficient for retention of somatic sensitivity. It is suggested that an inflow over several channels plays a role in providing the spatial-temporal sequence required for activating cortical neurons.Institute of Higher Nervous Activity and Neurophysiology, Academy of Sciences, USSR, Moscow. Translated from Neirofiziologiya, Vol. 2, No. 5, pp. 469–474, September–October, 1970.  相似文献   

20.
The somatosensory system is vulnerable to large amounts of noise distortion. But how does the central nervous system distinguish the peripheral inputs which carry information to the brain from that which does not possess information? To address this question we studied the effect of electrical stimulation of the median nerve on tactile spatial frequency perception in healthy subjects and Parkinson's disease (PD) patients. Subjects were categorized in two groups (healthy and PD patients) and were asked to report if a test tactile frequency pattern (TFP) was the same as the reference TFP given to the other hand. In each case stimulation was either present or absent on the median nerve of the hand holding the test pattern. We observed no impairment of tactile performance in the presence of electrical stimulation of the median nerve. This result together with previous work on direct stimulation of the somatosensory relay nucleus of the thalamus (Abbassian et al., Stereotact Funct Neurosurg 76: 19–28, 2001) in which the same result of no impairment of the tactile discrimination task was observed suggest a high degree of noise tolerance exists in the somatosensory pathway.  相似文献   

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