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1.
We introduce a mesoscopic scale chemotaxis model for traveling wave phenomena which is induced by food metric. The organisms of this simplified kinetic model have two discrete velocity modes, \(\pm s\) and a constant tumbling rate. The main feature of the model is that the speed of organisms is constant \(s\,{>}\,0\) with respect to the food metric, not the Euclidean metric. The uniqueness and the existence of the traveling wave solution of the model are obtained. Unlike the classical logarithmic model case there exist traveling waves under super-linear consumption rates and infinite population pulse-type traveling waves are obtained. Numerical simulations are also provided. 相似文献
2.
We develop a systems based model for prostate cancer, as a sub-system of the organism. We accomplish this in two stages. We first start with a general ODE that includes organism response terms. Then, to account for normally observed spatial diffusion of cell populations, the ODE is extended to a PDE that includes spatial terms. Numerical solutions of the full PDE are provided, and are indicative of traveling wave fronts. This motivates the use of a well known transformation to derive a canonically related (non-linear) system of ODEs for traveling wave solutions. For biological feasibility, we show that the non-negative cone for the traveling wave system is time invariant. We also prove that the traveling waves have a unique global attractor. Biologically, the global attractor would be the limit for the avascular tumor growth. We conclude with comments on clinical implications of the model. 相似文献
3.
Li B 《Journal of mathematical biology》2012,65(5):855-873
We propose an integro-difference equation model to predict the spatial spread of a plant population with a seed bank. The formulation of the model consists of a nonmonotone convolution integral operator describing the recruitment and seed dispersal and a linear contraction operator addressing the effect of the seed bank. The recursion operator of the model is noncompact, which poses a challenge to establishing the existence of traveling wave solutions. We show that the model has a spreading speed, and prove that the spreading speed can be characterized as the slowest speed of a class of traveling wave solutions by using an asymptotic fixed point theorem. Our numerical simulations show that the seed bank has the stabilizing effect on the spatial patterns of traveling wave solutions. 相似文献
4.
利用上下解方法研究了一个具有年龄结构的单种群离散反应扩散模型波前解的存在性,并证明了存在具有临界波速的波前解. 相似文献
5.
A model for chemotaxis in a bacteria-substrate mixture introduced by Keller and Segel, which is described by nonlinear partial differential equations, is studied analytically. The existence of traveling waves is shown for the system in which the substrate diffusion is taken into account and the chemotactic coefficient is greater than the motility one, and the instability of traveling waves is discussed. 相似文献
6.
We develop and investigate a continuum model for invasion of a domain by cells that migrate, proliferate and differentiate.
The model is applicable to neural crest cell invasion in the developing enteric nervous system, but is presented in general
terms and is of broader applicability. Two cell populations are identified and modeled explicitly; a population of precursor
cells that migrate and proliferate, and a population of differentiated cells derived from the precursors which have impaired
migration and proliferation. The equation describing the precursor cells is based on Fisher’s equation with the addition of
a carrying-capacity limited differentiation term. Two variations of the proliferation term are considered and compared. For
most parameter values, the model admits a traveling wave solution for each population, both traveling at the same speed. The
traveling wave solutions are investigated using perturbation analysis, phase plane methods, and numerical techniques. Analytical
and numerical results suggest the existence of two wavespeed selection regimes. Regions of the parameter space are characterized
according to existence, shape, and speed of traveling wave solutions. Our observations may be used in conjunction with experimental
results to identify key parameters determining the invasion speed for a particular biological system. Furthermore, our results
may assist experimentalists in identifying the resource that is limiting proliferation of precursor cells. 相似文献
7.
A quantitative approximation scheme for the traveling wave solutions in the Hodgkin-Huxley model
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Muratov CB 《Biophysical journal》2000,79(6):2893-2901
We introduce an approximation scheme for the Hodgkin-Huxley model of nerve conductance that allows calculation of both the speed and shape of the traveling pulses, in quantitative agreement with the solutions of the model. We demonstrate that the reduced problem for the front of the traveling pulse admits a unique solution. We obtain an explicit analytical expression for the speed of the pulses that is valid with good accuracy in a wide range of the parameters. 相似文献
8.
State transitions in the nervous system often take shape as traveling waves, whereby one neural state is replaced by another across space in a wave-like manner. In visual perception, transitions between the two mutually exclusive percepts that alternate when the two eyes view conflicting stimuli (binocular rivalry) may also take shape as traveling waves. The properties of these waves point to a neural substrate of binocular rivalry alternations that have the hallmark signs of lower cortical areas. In a series of experiments, we show a potent interaction between traveling waves in binocular rivalry and stimulus motion. The course of the traveling wave is biased in the motion direction of the suppressed stimulus that gains dominance by means of the wave-like transition. Thus, stimulus motion may propel the traveling wave across the stimulus to the extent that the stimulus motion dictates the traveling wave's direction completely. Using a computational model, we show that a speed-dependent asymmetry in lateral inhibitory connections between retinotopically organized and motion-sensitive neurons can explain our results. We argue that such a change in suppressive connections may play a vital role in the resolution of dynamic occlusion situations. 相似文献
9.
Traveling waves of calcium are widely observed under the condition that the free cytosolic calcium is buffered. Thus it is
of physiological interest to determine how buffers affect the properties of calcium waves. Here we summarise and extend previous
results on the existence, uniqueness and stability of traveling wave solutions of the buffered bistable equation, which is
the simplest possible model of the upstroke of a calcium wave. Taken together, the results show that immobile buffers do not
change the existence, uniqueness or stability of the traveling wave, while mobile buffers can eliminate a traveling wave.
However, if a wave exists in the latter case, it remains unique and stable.
相似文献
10.
In this paper, we proved that the one-dimensional crawling nematode sperm cell model proposed by Mogilner and Verzi (2003) supports traveling wave solutions if there is no disassembly of unbundled filaments in the cell. Uniqueness of traveling wave is established under additional assumptions and numerical examples are also given in the paper. Mathematical methods used include dynamical system techniques, implicit function theorem and global bifurcation theory.Revised version: 16 September 2003 相似文献
11.
James P. Roach Eshel Ben-Jacob Leonard M. Sander Michal R. Zochowski 《PLoS computational biology》2015,11(8)
Acetylcholine (ACh) is a regulator of neural excitability and one of the neurochemical substrates of sleep. Amongst the cellular effects induced by cholinergic modulation are a reduction in spike-frequency adaptation (SFA) and a shift in the phase response curve (PRC). We demonstrate in a biophysical model how changes in neural excitability and network structure interact to create three distinct functional regimes: localized asynchronous, traveling asynchronous, and traveling synchronous. Our results qualitatively match those observed experimentally. Cortical activity during slow wave sleep (SWS) differs from that during REM sleep or waking states. During SWS there are traveling patterns of activity in the cortex; in other states stationary patterns occur. Our model is a network composed of Hodgkin-Huxley type neurons with a M-current regulated by ACh. Regulation of ACh level can account for dynamical changes between functional regimes. Reduction of the magnitude of this current recreates the reduction in SFA the shift from a type 2 to a type 1 PRC observed in the presence of ACh. When SFA is minimal (in waking or REM sleep state, high ACh) patterns of activity are localized and easily pinned by network inhomogeneities. When SFA is present (decreasing ACh), traveling waves of activity naturally arise. A further decrease in ACh leads to a high degree of synchrony within traveling waves. We also show that the level of ACh determines how sensitive network activity is to synaptic heterogeneity. These regimes may have a profound functional significance as stationary patterns may play a role in the proper encoding of external input as memory and traveling waves could lead to synaptic regularization, giving unique insights into the role and significance of ACh in determining patterns of cortical activity and functional differences arising from the patterns. 相似文献
12.
Gerald Rosen 《Journal of theoretical biology》1975,49(2):311-321
The governing parabolic partial differential equations for the diffusion and chemotactic transport of a distribution of bacteria and for the diffusion and bacterial degradation of a distribution of chemotactic agent are supplemented with boundary and initial conditions that model the recent capillary tube experiments on the formation and propagation of traveling bands of chemotactic bacteria. An iteration procedure that takes the exact solution to the “diffusionless” problem as a first approximation is applied to solve the equations of the complete theoretical model. It is shown that satisfactory agreement with experiment obtains for the analytical results of the first approximation which relate the velocity of propagation and total number of bacteria cells per unit cross-sectional area in a traveling band to the constant parameters in the governing equations and supplementary conditions. The second approximation is shown to yield approximate analytical expressions for the solution functions which are in close correspondence with previously derived traveling band solutions for values of time after the initial period of formation. 相似文献
13.
Presented is a reaction-diffusion model for the interaction of pioneer and climax species. For certain parameters the system exhibits bistability and traveling wave solutions. Specifically, we show that when the climax species diffuses at a slow rate there are traveling wave solutions which correspond to extinction waves of either the pioneer or climax species. A leading order analysis is used in the one-dimensional spatial case to estimate the wave speed sign that determines which species becomes extinct. Results of these analyses are then compared to numerical simulations of wave front propagation for the model on one and two-dimensional spatial domains. A simple mechanism for harvesting is also introduced. 相似文献
14.
We consider a new model for biological invasions in periodic patchy environments, in which long-range taxis and population pressure are incorporated in the framework of reaction-diffusion-advection equations. We assume that long-range taxis is induced by a weighted integral of stimuli within a certain sensing range. Population pressure is incorporated in the diffusion coefficient that linearly increases with population density. We first analyze the model in the absence of population pressure and demonstrate how the sensing length of long-range taxis influences the range expansion pattern of invasive species and its rate of spread. The effects of population pressure are examined for both homogeneous and periodic patchy environments. For the homogeneous environment, an exact and explicit traveling wave solution and the spreading speed are obtained. For the periodic patchy environment, we find numerically that a population starting from any localized distribution evolves to a traveling periodic wave if the null solution of the RDA equation is locally unstable, and that the traveling wave speed significantly increases with increasing population pressure. Furthermore, the population pressure and taxis intensity synergistically enhance the spreading speed when they are increased together. 相似文献
15.
16.
In this paper we consider a class of one-dimensional cell motility models with increasing complexities beginning with a kinematic model and ending with a model based on viscoelastic theory. In many of these models, we establish the existence of traveling cell solutions and show numerically that the solutions of the time-dependent problem converge to the traveling cell solutions as t → ∞. As a result, we are able to predict the eventual length and speed of the cell. 相似文献
17.
Dispersal distance of heterogeneous populations 总被引:3,自引:3,他引:0
K. Yamamura 《Population Ecology》2002,44(2):93-101
Heterogeneity among individuals in a population is one of the important factors that influence the rate of population spread.
To incorporate the population heterogeneity into dispersal rate, we assume that the traveling duration varies following a
gamma distribution with a shape parameter k, where (1/k) indicates the heterogeneity in the traveling duration. The resultant distribution of the traveling distance, which is called
dispersal function, is then expressed by using a modified Bessel function of the second kind of order (k − 1). It is shown that the front of the distribution spreads with time in an accelerated manner during an early phase of expansion
if the heterogeneity is sufficiently large, which is consistent with the results from previous studies of biological invasions.
By using the data obtained from mark–recapture experiments using traps, we can obtain the maximum likelihood estimates of
three parameters: heterogeneity in the traveling duration, which is defined by (1/k); the mean dispersal ability, which is defined by the product of the diffusion coefficient and the mean traveling duration;
and the trap efficiency. The usefulness of this model is shown by using the data of mark–recapture experiments with the common
cutworm, Spodoptera litura (Fabricius) (Lepidoptera: Noctuidae).
Received: December 3, 2001 / Accepted: May 16, 2002 相似文献
18.
A. V. Shelobolin 《Plasma Physics Reports》2003,29(2):166-175
Drawbacks of the conventional model of electric breakdown in high-pressure gases are discussed. A new model that associates the propagation of a breakdown wave with the propagation of a traveling electromagnetic wave in a plasma waveguide is proposed. Based on the new model, the main physical parameters of a medium are estimated. 相似文献
19.
Motivated by the importance of understanding the dynamics of the growth and dispersal of plants in various environments, we introduce and analyze a discrete agent-based model based on a birth-jump process, which exhibit wave-like solutions. To rigorously analyze these traveling wave phenomena, we derive the diffusion limit of the discrete model and prove the existence of traveling wave solutions (sharp and continuously differentiable) assuming a logarithmic-type growth. Furthermore, we provide a variational speed for the minimum speed of the waves and perform numerical experiments that confirm our results. 相似文献
20.
In this paper, the repulsion effect of superinfecting virion by infected cells is studied by a reaction diffusion equation model for virus infection dynamics. In this model, the diffusion of virus depends not only on its concentration gradient but also on the concentration of infected cells. The basic reproduction number, linear stability of steady states, spreading speed and existence of traveling wave solutions for the model are discussed. It is shown that viruses spread more rapidly with the repulsion effect of infected cells on superinfecting virions, than with random diffusion only. For our model, the spreading speed of free virus is not consistent with the minimal traveling wave speed. With our general model, numerical computations of the spreading speed show that the repulsion of superinfecting virion promotes the spread of virus, which confirms, not only qualitatively but also quantitatively, the experimental result of Doceul et al. (Science 327:873–876, 2010). 相似文献