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Nuclear receptors (NRs) play pivotal roles in cell growth, proliferation, differentiation and homeostasis. Recent progress
demonstrates that NR is tightly linked to human disease such as cancer, diabetes and obesity. Here we explore NR expression
profiles in human tissue using systematic approaches. NR gene profiles reveal that individual NR has its own gene expression
signature depending on tissue type. Of many organs, NRs expression is enriched in liver. Expression of many NRs was significantly
changed in liver cancer. Notably, NR0B2/SHP expression level was significantly decreased in human liver cancer but not in normal liver. In addition, expression of SHP
is well associated with good prognosis. SHP gene network analysis based on microarray data in liver cancer shows that SHP
regulates cell proliferation and metabolism related gene sets. Our systematic approaches suggest that loss of SHP expression
in liver might be key genetic events during hepatocarcinogenesis. 相似文献
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Nuclear receptors: decoding metabolic disease 总被引:2,自引:0,他引:2
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Luqiao Wang Gayani Nanayakkara Qian Yang Hongmei Tan Charles Drummer Yu Sun Ying Shao Hangfei Fu Ramon Cueto Huimin Shan Teodoro Bottiglieri Ya-feng Li Candice Johnson William Y. Yang Fan Yang Yanjie Xu Hang Xi Weiqing Liu Jun Yu Eric T. Choi Xiaoshu Cheng Hong Wang Xiaofeng Yang 《Journal of hematology & oncology》2017,10(1):168
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