共查询到20条相似文献,搜索用时 46 毫秒
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A CRE/ATF-like site in the upstream regulatory sequence of the human interleukin 1 beta gene is necessary for induction in U937 and THP-1 monocytic cell lines. 下载免费PDF全文
J G Gray G Chandra W C Clay S W Stinnett S A Haneline J J Lorenz I R Patel G B Wisely P J Furdon J D Taylor et al. 《Molecular and cellular biology》1993,13(11):6678-6689
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Comparison of the binding sites for the Escherichia coli cAMP receptor protein at the lactose and galactose promoters 总被引:15,自引:2,他引:13
Polyacrylamide gel electrophoresis has been used to visualise and quantitate complexes between the Escherichia coli cyclic AMP receptor protein (CRP) and DNA fragments containing the promoter region of either the E. coli galactose or lactose operons. We show that, although CRP binding to the gal fragment is weaker than binding to the lac fragment, in each case, stable complexes are formed between one dimer of CRP and one molecule of DNA. We have examined the effects of a series of deletions and point mutations in the gal promoter region on CRP binding. From the position of deletions and mutations which prevent the formation of stable complexes, we deduce the location and extent of the sequence at the CRP binding site. We show that it covers approximately the same length of sequence as the binding site at the lac promoter. Unlike the lac site, the gal site contains no palindromic sequence. We discuss the importance of symmetry in the sequence at CRP binding sites and the validity of CRP binding consensus sequences which have been proposed. 相似文献
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Cis-regulation of the L-type pyruvate kinase gene promoter by glucose, insulin and cyclic AMP. 总被引:11,自引:0,他引:11 下载免费PDF全文
M O Bergot M J Diaz-Guerra N Puzenat M Raymondjean A Kahn 《Nucleic acids research》1992,20(8):1871-1877
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Nadia Canu Roberta Possenti Anna Maria Rinaldi Eugenia Trani Andrea Levi 《Journal of neurochemistry》1997,68(4):1390-1399
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