Validation of Chinese Version of Polycystic Ovary Syndrome Health-Related Quality of Life Questionnaire (Chi-PCOSQ)

ObjectivesTo evaluate the responsiveness, longitudinal validity, and measurement invariance of the Chinese version of the Polycystic Ovary Syndrome Health-related Quality of Life Questionnaire (Chi-PCOSQ).ResultsWith improved 2-hour glucose and insulin levels, we also found significantly increased Chi-PCOSQ total and individual domain scores (total score: t (49) = 5.20; p < 0.001, domain scores: t (49) = 2.72 to 3.87; p < 0.01), except for hair growth. Half of the domains scores (3 of 6) and the total score of Chi-PCOSQ had a medium responsiveness, but WHOQOL-BREF was not sufficiently responsive to clinical changes of PCOS. Improved PCOS-specific health-related quality of life (HRQoL), as indicated by Chi-PCOSQ scores, was significantly associated with improved 2-hour glucose and insulin levels. All indices of the data-model fit of the Chi-PCOSQ structure were satisfactory, except for the slightly high standardized root mean square residual values (0.087 to 0.088). The measurement invariance of Chi-PCOSQ was supported across time.ConclusionChi-PCOSQ is sufficiently sensitive in detecting clinical changes and its measurement structure is suitable for Chinese women with PCOS. It is thus a promising tool for assessing the HRQoL of ethnic Chinese women with PCOS.     

Validation of the Chinese Version of the Quality of Nursing Work Life Scale

Quality of Nursing Work Life (QNWL) serves as a predictor of a nurse’s intent to leave and hospital nurse turnover. However, QNWL measurement tools that have been validated for use in China are lacking. The present study evaluated the construct validity of the QNWL scale in China. A cross-sectional study was conducted conveniently from June 2012 to January 2013 at five hospitals in Guangzhou, which employ 1938 nurses. The participants were asked to complete the QNWL scale and the World Health Organization Quality of Life abbreviated version (WHOQOL-BREF). A total of 1922 nurses provided the final data used for analyses. Sixty-five nurses from the first investigated division were re-measured two weeks later to assess the test-retest reliability of the scale. The internal consistency reliability of the QNWL scale was assessed using Cronbach’s α. Test-retest reliability was assessed using the intra-class correlation coefficient (ICC). Criterion-relation validity was assessed using the correlation of the total scores of the QNWL and the WHOQOL-BREF. Construct validity was assessed with the following indices: χ² statistics and degrees of freedom; relative mean square error of approximation (RMSEA); the Akaike information criterion (AIC); the consistent Akaike information criterion (CAIC); the goodness-of-fit index (GFI); the adjusted goodness of fit index; and the comparative fit index (CFI). The findings demonstrated high internal consistency (Cronbach’s α = 0.912) and test-retest reliability (interclass correlation coefficient = 0.74) for the QNWL scale. The chi-square test (χ² = 13879.60, df [degree of freedom] = 813 P = 0.0001) was significant. The RMSEA value was 0.091, and AIC = 1806.00, CAIC = 7730.69, CFI = 0.93, and GFI = 0.74. The correlation coefficient between the QNWL total scores and the WHOQOL-BREF total scores was 0.605 (p<0.01). The QNWL scale was reliable and valid in Chinese-speaking nurses and could be used as a clinical and research instrument for measuring work-related factors among nurses in China.     

Development of Chinese Version of Polycystic Ovary Syndrome Health-Related Quality of Life Questionnaire (Chi-PCOSQ)

Objectives

To develop the Chinese version of the Polycystic Ovary Syndrome Health-related Quality of Life Questionnaire (Chi-PCOSQ).

Research Design and Method

This cross-sectional study was conducted in a medical center in Taiwan. Eighty women who met the criteria were enrolled: female, age range of 18–45 years, competent in the Chinese language, had been diagnosed with polycystic ovary syndrome (PCOS), and were regularly followed at outpatient clinics (defined as at least two outpatient visits before enrollment). The PCOSQ was translated and culturally adapted according to standard procedures. A semi-structured interview was applied to assess face validity. Exploratory factor analysis (EFA) was applied to determine scale constructs. Measurements of internal consistency via Cronbach’s α, test-retest reliability via intraclass correlation coefficient (ICC), construct validity, and discriminative validity were performed.

Results

Five additional items, representing the issues of acne, hair loss, and fear of getting diabetes, were incorporated into the original scale. A six-factor structure emerged as a result of the EFA, explaining 71.9% of the variance observed. The reliability analyses demonstrated satisfactory results for Cronbach’s α ranging from 0.78–0.96, and for ICC ranging from 0.73–0.86. Construct validity was confirmed by significant correlation between the domains of the Chi-PCOSQ and generic health-related quality of life (HRQoL) measures (WHOQOL-BREF, EQ-5D) and clinical parameters (body mass index, waist-hip ratio, blood pressure). The known-group analysis indicated that the Chi-PCOSQ is a discriminative tool that differentiates patients according to their HRQoL.

Conclusion

The Chi-PCOSQ seems internally consistent, culturally acceptable, and our preliminary evidence suggests that it may be reliable and valid. The Chi-PCOSQ is a promising assessment tool to address the HRQoL of women affected by PCOS in Chinese-speaking countries and to further identify ethnic/cultural differences in the HRQoL of women with PCOS.     

纤维肌痛综合征患者的生存质量及其影响因素研究

目的:探讨纤维肌痛综合征患者生存质量及其影响因素。方法:选择2014年2月至2015年2月在哈医大一院风湿免疫科门诊就诊的纤维综合征患者共40例,采用医师与患者沟通以及问卷调查的方法收集患者的性别、年龄、病程以及并发症情况,并对患者疼痛、疲劳、焦虑抑郁、睡眠情况以及生存质量进行评估。同时随机选取一般正常人群40例作为对照组。应用SPSS l7.0统计软件进行统计学分析。结果:纤维肌痛综合征患者生存质量显著低于对照组(P0.05);疲劳程度、焦虑抑郁为影响生存质量的主要因素,呈负相关(P0.05);疼痛与生存质量中活力维度呈负相关(P0.05),疲劳程度与生理职能、一般健康状况、社会功能以及情感职能4个维度呈负相关(P0.05),焦虑抑郁程度以及睡眠质量与躯体功能、躯体疼痛以及社会功能3个维度呈负相关(P0.05)。结论:影响纤维肌痛综合征患者生存质量的因素是多方面的,要想提高患者的生存质量,不仅要缓解疼痛及其相关症状,更要同时改善如疲劳、抑郁焦虑等症状。     

Validation of a Health-related Quality of Life (QoL) Questionnaire for Owners of Dogs with Heart Disease

ABSTRACT

In humans, heart disease is associated with high caregiver burden and stress, which can negatively affect the health-related quality of life (hrQoL) of both patient and caregiver. The effect of a dog’s heart disease on owners’ hrQoL has not been reported. Therefore, the objective of this study was to develop and validate a hrQoL questionnaire for owners of dogs with heart disease, with the hypothesis that heart disease would impact the hrQoL of owners. Owners of dogs with degenerative mitral valve disease, dilated cardiomyopathy, and arrhythmogenic right ventricular cardiomyopathy were eligible for the study. A 7-item questionnaire was developed, with a possible range of scores from 0–35 (higher scores indicated worse owner hrQoL). The questionnaire was self-administered by owners and results were analyzed to determine validity, test-retest reliability, and internal consistency. The Functional EvaluaTion of Cardiac Health (FETCH) questionnaire was used to assess dogs’ hrQoL. Two hundred and seventeen owners of dogs with heart disease were enrolled. Median owner hrQoL score was 6 (range, 0–31) and median FETCH hrQoL score was 7 (range, 0–70). The owner hrQoL score was correlated with the FETCH score (r = 0.76, p < 0.001) and severity of dogs’ disease (r = 0.53, p < 0.001). Test-retest reliability was high (r = 0.83, p < 0.001). These results suggest that the owner hrQoL questionnaire has good reliability and validity, and that further testing of this questionnaire is warranted to optimize communication with owners regarding the care of dogs with heart disease.     

自我效能改善白血病晚期患者生活质量的应用

目的：在自我效能理论指导下对白血病晚期患者改进护理措施,改善其生活质量。方法：采用目的性抽样,对2010年1月至2012年5月间异常的患者,通过gses表格内容,supph测评内容评估,在临床医生和心理医生的指导下改善传统护理方法,对每个患者出现的不适症状分别对待,使患者意识到需要接受挑战而坚持到底的毅力,使患者相信自身对疾病的可控感。结果：根据护理评价结果建立新措施体系,结果显示抑郁得分显著高于国内常模,自我效能总分与抑郁总分无明显线性相关;作出决策维度与躯体性障碍存在负相关性（r=-0．319,P〈0．05：）;积极态度分别与抑郁总分（r=0．345,P〈0．05）、躯体性障碍（r=0．322,P〈0．05）存在正相关性。自我效能可改善白血病晚期患者生活质量,测评结果显示及专业医生的积极评价说明其具有可信度。结论：异常变化的micro RNA可能对高糖诱导的腹膜间皮细胞EMT具有重要调控作用。     

子宫肌瘤动脉栓塞术改善子宫肌瘤患者预后与生活质量研究

目的:评估子宫肌瘤动脉栓塞术(UAE)改善子宫肌瘤患者预后与生活质量。方法:选取在我院介入科住院治疗的400例子宫肌瘤患者,记录患者的再干预率和出血有关的临床症状。将症状持续、恶化、症状复发和再干预定义为治疗失败(TF)。使用Kaplan-Meier分析计算成功治疗的累积率。运用Cox回归分析计算临床或形态学预测因子。评估患者生活质量和更年期的变化情况。结果:400例患者中,328例患者(82.0%)完成随访。共有54例TF,对其中46例进行了再干预治疗。Kaplan-Meier分析表明,5年后TF累积率为23.3%。Cox回归分析表明,与45岁以上女性相比,40岁以下女性更易发生TF(OR=2.29,95%CI:1.02-5.19,P=0.048)。非TF患者治疗后疾病相关生活质量显著改善(P0.001)。274例非TF患者中,有62(22.6%)例停经平均年龄为52岁。结论:UAE可以对83.5%的子宫肌瘤患者相关的症状予以长期控制,并使其生活正常化。与接近绝经期妇女相比,TF在年轻女性中的发生率更高。     

工作倦怠与交通警察生活质量的关系

目的:探讨交通警察工作倦怠与生活质量的关系。方法:采用MBI-GS和生活质量问卷调查了某市185名交通警察,运用相关分析和回归分析处理数据。结果:交通警察的情绪衰竭与其生活质量显著负相关(P<0.01);玩世不恭也与生活质量显著负相关(P<0.01);职业效能与生活质量显著正相关(P<0.05)。结论:降低工作倦怠,可以有效提高交通警察的生活质量。     

工作倦怠与交通警察生活质量的关系

目的：探讨交通警察工作倦怠与生活质量的关系。方法：采用MBI-GS和生活质量问卷调查了某市185名交通警察,运用相关分析和回归分析处理数据。结果：交通警察的情绪衰竭与其生活质量显著负相关（P〈0.01）;玩世不恭也与生活质量显著负相关（P〈0.01）;职业效能与生活质量显著正相关（P〈0.05）。结论：降低工作倦怠,可以有效提高交通警察的生活质量。     

Development of a Brief Measure to Assess Quality of Life in Obesity

Objective: Obesity researchers have a growing interest in measuring the impact of weight and weight reduction on quality of life. The Impact of Weight on Quality of Life questionnaire (IWQOL) was the first self‐report instrument specifically developed to assess the effect of obesity on quality of life. Although the IWQOL has demonstrated excellent psychometric properties, its length (74 items) makes it somewhat cumbersome as an outcome measure in clinical research. This report describes the development of a 31‐item version of the IWQOL (IWQOL‐Lite). Research Methods and Procedures: IWQOLs from 996 obese patients and controls were used to develop the IWQOL‐Lite. Psychometric properties of the IWQOL‐Lite were examined in a separate cross‐validation sample of 991 patients and controls. Results: Confirmatory factor analysis provided strong support for the adequacy of the scale structure. The five identified scales of the IWQOL‐Lite (Physical Function, Self‐Esteem, Sexual Life, Public Distress, and Work) and the total IWQOL‐Lite score demonstrated excellent psychometric properties. The reliability of the IWQOL‐Lite scales ranged from 0.90 to 0.94 and was 0.96 for the total score. Correlations between the IWQOL‐Lite and collateral measures supported the construct validity of the IWQOL‐Lite. Changes in IWQOL‐Lite scales over time correlated significantly with changes in weight, supporting its sensitivity to change. Significant differences in IWQOL‐Lite scale and total scores were found among groups differing in body mass index, supporting the utility of the IWQOL‐Lite across the body mass index spectrum. Discussion: The IWQOL‐Lite appears to be a psychometrically sound and clinically sensitive brief measure of quality of life in obese persons.     

恶性肿瘤患者营养状况与生活质量的关系

目的：探讨恶性肿瘤患者营养状况与生活质量间的相关关系。方法：应用改良SGAN评估法和SF-36健康调查量袁对65例恶性肿瘤患者进行营养状况和生活质量评估,并对其做相关性分析。结果：恶性肿瘤患者的生活质量各维度均明显降低,并随营养状况的下降而降低。结论：恶性肿瘤患者的生活质量明显下降,营养状况与生活质量密切相关,提示提高患者营养状况可以改善生活质量。     

围手术期健康教育对全肺切除术后患者生存质量的影响

目的:探讨围手术期有效健康教育对患者全肺切除术后长期生活质量(QOL)的影响。方法:随机将100例全肺切除术后患者分为二组,分别采取对患者及家属有效健康教育干预和无干预措施,采用欧洲癌症治疗与研究组织癌症生存量表核心量表(EORTC QLQ-C30,简称QLQ-C30)中文版评估病人的生活质量,对术前及术后1,3,6和12个月的QLQ-C30得分与参考值进行比较。结果:1)两组患者术后长期生活质量中的功能得分无统计学差异(P0.05);2)症状方面,术后呼吸困难,疼痛明显加重;术后第6个月疲乏及经济困难明显加重;术后第12个月起,经济困难状况好转,较术前无明显差异(P0.05);3)无干预组与有效健康教育组在体力功能、角色功能、情绪功能及总体状况方面有统计学差异(P0.05);4)在术后,无干预组在疲劳和呼吸困难方面的QLQ-C30得分比有效健康教育组的低,且有统计学差异(P0.05),但是在12月之后直至病人基本恢复与有效健康教育组之间无统计学差异(P0.05)。结论:围手术期实施有效健康教育,可使全肺切除患者术后生活质量明显提高;比较两种护理措施术后生活质量,有效健康教育组较无干预组患者功能恢复较快,自觉不良症状更少。     

显微血管减压术对面肌痉挛患者生活质量的影响

目的:研究显微血管减压术对面肌痉挛(HFS Hemifacial Spasm)患者生活质量的影响。方法:对2014年至2016年底在哈医大一院神经外科四科接受显微血管减压手术(MVD Mcrovascular Decompression)治疗的40名面肌痉挛患者进行生活质量量表(QOL Quality of Life)评分,对患者的疗效及治疗前后生活质量的变化情况进行统计学分析。结果:治疗后,MVD的明显缓解率为95%,手术前后不同生活质量项目评分的差异具有统计学意义(P<0.05),术前QOL量表评分总值为21.83±2.01,术后总值为2.15±0.8,术后QOL量表评分总值较术前显著降低(P<0.05)。结论:显微血管减压手术对面肌痉挛患者的症状缓解效果显著,同时可以明显改善患者的生活质量,特别是对患者内心窘迫的改善最为明显。     

恶性肿瘤患者营养状况与生活质量的关系

目的:探讨恶性肿瘤患者营养状况与生活质量间的相关关系。方法:应用改良SGAN评估法和SF-36健康调查量表对65例恶性肿瘤患者进行营养状况和生活质量评估,并对其做相关性分析。结果:恶性肿瘤患者的生活质量各维度均明显降低,并随营养状况的下降而降低。结论:恶性肿瘤患者的生活质量明显下降,营养状况与生活质量密切相关,提示提高患者营养状况可以改善生活质量。     

电脑版Wisconsin卡片分类试验（中文版）的开发研制

Ｗｉｓｃｏｎｓｉｎ卡片分类试验（Ｗｉｓｃｏｎｓｉｎｃａｒｄｓｏｒｔｉｎｇｔｄｓｔ,ＷＣＳＴ）是一种临床神经心理测试工具。ＷＣＳＴ计算机化的必要性：１．传统的ＷＣＳＴ可因不同主剂间的主观因素造成测试结果的人为差异,２．在对研究对象进行ＰＥＴ脑功能显像时,使用传统的ＷＣＳＴ作为认知激活介入是不行的,电脑版ＷＣＳＴ（中文版）的设计要求及性能指标;１．设计要求,使用简便,客观评估被试的测试结果,结果记录及     

出血性卒中后抑郁患者认知功能与生活质量的研究

目的:探讨不同时期出血性脑卒中后抑郁(Post-Stroke Depression,PSD)患者认知功能和生活质量的特征。方法:采用前瞻性队列研究,对57例PSD患者和91例非PSD(None PSD,NPSD)患者在基线期、6周和12周后分别进行临床神经功能缺损程度评分量表(China Stroke Scale,CSS)、汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)、蒙特利尔认知评估量表(Montreal Cognitive Assessment,Mo CA)和Barthel指数(Barthel Index,BI)的评估。结果:基线期PSD和NPSD患者Mo CA总分[分别为(11.6±2.9)分、(11.2±3.1)分]和BI总分[分别为(45.6±8.3)分、(46.2±7.2)分],差异无统计学意义(P0.05);治疗6周和12周后PSD组Mo CA总分[分别为(13.4±2.3)分、(18.2±3.2)分]和BI总分[分别为(63.8±6.5)分、(77.2±4.1)分]均低于NPSD组[分别为(15.8±2.8)分、(22.6±2.4)分;(72.2±7.5)分、(85.8±5.6)分],差异有统计学意义(P0.000)。结论:在卒中的康复后期,PSD患者较NPSD患者认知功能障碍损害更严重,生活质量更差。推测认知功能是PSD患者长期预后的独立预测因素,可为PSD患者康复策略的制定提供帮助。     

家庭干预对喉癌患者术后生活质量的影响

目的:探讨家庭干预对喉癌术后患者生活质量的影响。方法:将66例喉癌术后患者随机分为干预组和时照组,两组病人均进行常规治疗和护理,干预组在此基础上对患者实施针对性家庭干预。采用Terrell生活质量调查表分别在实施干预前及实施干预后进行评估。结果:干预组患者干预后对健康知识掌握率显著高于对照组(P<0.05),生活质量明显高于对照组(P<0.05)。结论:对喉癌术后病人实施针对性家庭干预,可以提高喉癌术后病人生活质量。     

健康教育路径对甲状腺癌手术患者生活质量的影响

目的:探讨健康教育路径对甲状腺癌手术病人生活质量的影响。方法:将78例行甲状腺癌择期手术患者随机分为实验组和对照组,每组各39例,对照组采用传统健康教育方法,实验组采用健康教育路径进行教育,采用癌症患者生活质量指数评定量表(QLI中文修订版)、焦虑自评量表(SAS)和抑郁自评量表(SDS),分别于入组时、术后1个月、6个月对两组病人进行问卷调查,评估病人生活质量及焦虑、抑郁程度。结果:实验组甲状腺癌手术患者生活质量指数高于对照组,焦虑抑郁评分低于对照组(P0.05),健康知识掌握情况高于对照组(P0.05)。结论:健康教育路径在甲状腺癌手术患者宣教中效果显著,对甲状腺癌手术病人生活质量的提高有明显作用,可在临床护理工作中逐渐推广。     

不同出生体重儿童的生命质量研究

目的:探讨不同出生体重对学龄期儿童生命质量及影响因素.方法:采用Achendach儿童行为量表、儿少主观生命质量问卷及自制儿童生命质量影响因素问卷,对台湾基隆市8-11岁儿童进行调查,依研究对象按照不同出生体重分组并进行分析.结果:在所调查的350名儿童中,出现行为问题的儿童有21.14%(74/350).使用Logistic回归检验发现行为问题与父亲与主要养育人的教育程度、受试儿童是否对家庭造成心理负担及经济负担四个方面有密切关系.对不同出生体重儿童主观生命质量满意度的分析结果提示:低出生体重儿与正常出生体重儿相比,在生命质量中的情感成份满意度较低(F=2.601;P=0.028);而巨大儿在认知成份满意度较正常出生体重儿差(F=3.189;P=0.012),且多元逐步回归发现:主要养育人的教育程度与母亲每周与孩子相处时间的长短是影响儿童主观生命质量满意度的因素.结论:低出生体重儿生命质量的情感成份满意度较低.而巨大儿生命质量的认知成份满意度较差,出生体重是影响儿童生命质量的因素.     

糖尿病周围神经病变患者生活质量调查研究

目的:探讨糖尿病周围神经病变患者生活质量现状和影响因素.方法:采用自编问卷、抑郁自评量表(SDS)、焦虑自评量表(SAS)、社会支持评定量表(SSRS)、匹兹堡睡眠质量指数问卷(PSQI)和汉化版简明健康调查表(SF-36)量表对2010年10月～2012年10月在我院内分泌科住院治疗的50例糖尿病周围神经病变患者和同期50例在我院健康体检者进行测评,采用SPSS16.0软件进行分析找出糖尿病周围神经病变患者生活质量现状和影响因素.结果:糖尿病周围神经病变患者的生活质量明显低于健康体检者,有显著性差异(P＜0.05).多元线性逐步回归分析发现:文化程度高、患者对疾病了解多、社会支持评定量表总分高与糖尿病周围神经病变患者生活质量正相关,而慢性并发症种类多、有睡眠问题、焦虑抑郁标准分高与糖尿病周围神经病变患者生活质量负相关.结论:糖尿病周围神经病变患者生活质量较低,其生活质量受多方面因素的影响,我们应该采取针对性的干预措施来改善患者的生活质量.