The Dugong Action Plan for the South Pacific: An Evaluation Based on the Need for International and Regional Conservation of Sirenians

Abstract

The purpose of this article is to set out the essential requirements for a successful regional agreement for Sirenians in the South Pacific. To achieve this, the current Dugong Action Plan, which is being formed under the auspice of the South Pacific Regional Environmental Program, will be juxtaposed against the “best practice” in this area, as evinced by current development in international environmental law and policy relating to Sirenians.     

Nationalist Anxiety or the Fear of Losing Your Other

The nation of the nationalists is always conceived to be in crisis. There is always an other standing between them and ‘it’. ‘It’ is often the impossible goal of a ‘totally gratifying nation’. Within a psychoanalytic framework, gratifying this nation is perceived as a fantasy, an object-cause of desire (Lacan), that is, a practical impossibility that neverthless keeps the practitioner trying to reach it. Within such a framework the other standing between the nationalists and their goal becomes a necessary subjective construction which allows the conversion of the impossibility of the nationalist fantasy into deferred possibility. The crisis presented by nationalist thought as triggered by the presence of the other is in fact a mode of reproducing the nationalists' belief in themselves and their nation. The ‘real’ crisis is when nationalists ‘lose’ their other and are forced to face the impossibility of the desired nation. Such situations can be described as states of nationalist anxiety. This paper, based on research during the civil war in Lebanon, examines certain events where the Lebanese Christian Nationalists were faced with the threat of losing their Muslim other. The paper describes the states of anxiety generated by this ‘threat’ and the nature of the strategies the Christian militias deployed to bring their state of anxiety to an end.     

Developing Ways to Evaluate in the Laboratory How Inhalation Devices Will Be Used by Patients and Care-Givers: The Need for Clinically Appropriate Testing

The design of methods in the pharmaceutical compendia for the laboratory-based evaluation of orally inhaled product (OIP) performance is intentionally aimed for simplicity and robustness in order to achieve the high degree of accuracy and precision required for the assurance of product quality in a regulated environment. Consequently, performance of the inhaler when used or even misused by the patient or care-giver has often not been assessed. Indeed, patient-use-based methodology has been developed in a somewhat piecemeal basis when a need has been perceived by the developing organization. There is, therefore, a lack of in-use test standardization across OIP platforms, and often important details have remained undisclosed beyond the sponsoring organization. The advent of international standards, such as ISO 20072:2009, that focus specifically on the OIP development process, together with the need to make these drug delivery devices more patient-friendly as an aid to improving compliance, is necessitating that clinically appropriate test procedures be standardized at the OIP class level. It is also important that their capabilities and limitations are well understood by stakeholders involved in the process. This article outlines how this process might take place, drawing on current examples in which significant advances in methodology have been achieved. Ideally, it is hoped that such procedures, once appropriately validated, might eventually become incorporated into the pharmacopeial literature as a resource for future inhaler developers, regulatory agencies, and clinicians seeking to understand how these devices will perform in use to augment ongoing product quality testing which is adequately served by existing methods.     

Direct Action of Light in Naturally Pigmented Muscle Fibers : I. Action spectrum for contraction in eel iris sphincter

Contraction due to light in excised eel irises appears to follow a simple first order law. The action spectrum for contraction has a maximum which agrees with the eel rhodopsin absorption maximum. Inasmuch as rhodopsin is the rod pigment-opsin complex and the iris sphincter pupillae evolves from the pigment epithelium of the retina in the region of the iris, the muscle pigment might be the same as the visual pigment. In the human eye the contraction of the iris sphincter is activated only by light incident on the retina and the pupil diameter varies inversely with the square root of the light intensity. The inverse first power relation observed in the present experiments suggests a more primitive origin for the light reaction in eel irises. Relaxation is a much slower process and can be approximated as the sum of two first order processes.