A gamma Bence-Jones protein in guinea pigs.

1. The L2C lymphocytic leukaemia in strain-2 guinea pigs is accompanied by a protein in the urine resembling a homogenous immunoglobulin light chain. 2. The amino acid sequence over the first 20 residues demonstrates a close analogy with a human gamma chain of V region subgroup IV. 3. The protein is apparently synthesized by the leukaemic cells and thus represents a monoclonal light chain, i.e. a Bence-Jones protein.     

Crystallographic data on a complete kappa-type human Bence-Jones protein.

A complete human κ-type Bence—Jones protein (Fin) has been isolated and crystallized. Immunochemical and physicochemical characterization of protein Fin indicates that it is of the κ-chain subgroup, κII, and that it consists of two non-covalently bound intact monomers having a molecular weight of ~23,000 Crystals of Bence—Jones protein Fin obtained from ammonium sulfate solutions have the orthorhombic space group P2₁2₁2₁ with cell dimensions $\text{a = 132.0}\text{A}\text{?}\text{, b = 93.3}\text{A}\text{?}\text{, and}\text{c = 42.3}\text{A}\text{?}$. The asymmetric unit consists of a dimer of molecular weight ~46,000.