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Methyl-CpG-binding proteins. Targeting specific gene repression. 总被引:25,自引:0,他引:25
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HDAC4 deacetylase associates with and represses the MEF2 transcription factor. 总被引:28,自引:0,他引:28
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E A Miska C Karlsson E Langley S J Nielsen J Pines T Kouzarides 《The EMBO journal》1999,18(18):5099-5107
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Methyl CpG-binding proteins and transcriptional repression. 总被引:19,自引:0,他引:19
P A Wade 《BioEssays : news and reviews in molecular, cellular and developmental biology》2001,23(12):1131-1137
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Classical histone deacetylases (HDACs) are enzymes that can hydrolytically cleave acetyl-Lys in histones and other proteins and serve as established drug targets in some forms of cancer. Class I HDACs 1–3 typically exist in a range of multiprotein complexes inside cells and show distinct biological functions in modulating gene expression. In recent years, it has become possible to purify and analyze the structure and enzymatic properties of several of these HDAC complexes, including CoREST, MiDAC, NuRD, Sin3, SMRT, MIER, and RERE. Here, we summarize what is experimentally established and/or computationally predicted about the structure of these complexes to describe their particular catalytic activities and site-specificities with modified nucleosome substrates. 相似文献
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