5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology

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GPCR homo-oligomerization

Cartoon depictions of (a) Dynamic interchange between receptor monomers, (homo, orange GPCR1, and hetero, orange GPCR1 and green GPCR2) dimers and oligomers which may be ligand regulated (orange sphere). (b) Signalling cross-talk between protomers of a dimer. Left: ligand (orange sphere) binds to one protomer and the conformational change transmitted to the second protomer results in signalling through activation of a Gα subunit (blue). Right: ligand (green sphere) binding to the second protomer may modulate signalling (large or small yellow flash).

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Structural Connection between Activation Microswitch and Allosteric Sodium Site in GPCR Signaling

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Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits

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Radical S-adenosylmethionine enzyme catalyzed thioether bond formation in sactipeptide biosynthesis

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trans-Cyclooctene — a stable,voracious dienophile for bioorthogonal labeling

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Recent progress in synthetic and biological studies of GPI anchors and GPI-anchored proteins

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Synthetic heparin and heparan sulfate oligosaccharides and their protein interactions

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Cryptic organelle homology in apicomplexan parasites: insights from evolutionary cell biology

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Frontiers of yeast metabolic engineering: diversifying beyond ethanol and Saccharomyces

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The details in the distributions: why and how to study phenotypic variability

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Engineering a local microenvironment for pancreatic islet replacement

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Meta-omic characterization of prokaryotic gene clusters for natural product biosynthesis

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Accelerated protein engineering for chemical biotechnology via homologous recombination

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Somewhat in control — the role of transcription in regulating microbial metabolic fluxes

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Potential of industrial biotechnology with cyanobacteria and eukaryotic microalgae

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Isotopically non-stationary metabolic flux analysis: complex yet highly informative

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Extracellular matrix signaling in morphogenesis and repair

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Baculovirus expression: tackling the complexity challenge

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The cytosol must flow: intercellular transport through plasmodesmata

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