Gene finding in novel genomes

Background  

Computational gene prediction continues to be an important problem, especially for genomes with little experimental data.     

Intermediate filament-co-localized molecules with myosin heavy chain epitopes define distinct cellular domains in hair follicles and epidermis

Background  

Proteins linking intermediate filaments to other cytoskeletal components have important functions in maintaining tissue integrity and cell shape.     

Preferred analysis methods for Affymetrix GeneChips revealed by a wholly defined control dataset

Background  

As more methods are developed to analyze RNA-profiling data, assessing their performance using control datasets becomes increasingly important.     

Bridging the phenotypic gap: Real-time assessment of mitochondrial function and metabolism of the nematode <Emphasis Type="Italic">Caenorhabditis elegans</Emphasis>

Background  

The ATP levels of an organism are an important physiological parameter that is affected by genetic make up, ageing, stress and disease.     

Dynamics of a disabled population in Morocco

Background  

The disabled population constitutes a class of people needing special care and necessitating important economic and social effort.     

New statistical potential for quality assessment of protein models and a survey of energy functions

Background  

Scoring functions, such as molecular mechanic forcefields and statistical potentials are fundamentally important tools in protein structure modeling and quality assessment.     

Automatic noninvasive measurement of systolic blood pressure using photoplethysmography

Background  

Automatic measurement of arterial blood pressure is important, but the available commercial automatic blood pressure meters, mostly based on oscillometry, are of low accuracy.     

MochiView: versatile software for genome browsing and DNA motif analysis

Background  

As high-throughput technologies rapidly generate genome-scale data, it becomes increasingly important to visually integrate these data so that specific hypotheses can be formulated and tested.     

Identification of metabolic system parameters using global optimization methods

Background  

The problem of estimating the parameters of dynamic models of complex biological systems from time series data is becoming increasingly important.     

Gene expression analysis indicates extensive genotype-specific crosstalk between the conjugative F-plasmid and the E. coli chromosome

Background  

Plasmids are an important component of the bacterial genome, but the crosstalk between genes encoded on the chromosome and on the plasmid is still poorly understood.     

Identification of biomolecule mass transport and binding rate parameters in living cells by inverse modeling

Background  

Quantification of in-vivo biomolecule mass transport and reaction rate parameters from experimental data obtained by Fluorescence Recovery after Photobleaching (FRAP) is becoming more important.     

Comparison of estrogens and estrogen metabolites in human breast tissue and urine

Background  

An important aspect of the link between estrogen and breast cancer is whether urinary estrogen levels are representative of the intra-tissue levels of bioavailable estrogens.     

Exercise-induced up-regulation of MMP-1 and IL-8 genes in endurance horses

Background  

The stress response is a critical factor in the training of equine athletes; it is important for performance and for protection of the animal against physio-pathological disorders.     

Discovery of protein-protein interactions using a combination of linguistic,statistical and graphical information

Background  

The rapid publication of important research in the biomedical literature makes it increasingly difficult for researchers to keep current with significant work in their area of interest.     

Robust discovery of periodically expressed genes using the laplace periodogram

Background  

Time-course gene expression analysis has become important in recent developments due to the increasingly available experimental data. The detection of genes that are periodically expressed is an important step which allows us to study the regulatory mechanisms associated with the cell cycle.     

Sample processing for DNA chip array-based analysis of enterohemorrhagic <Emphasis Type="Italic">Escherichia coli</Emphasis> (EHEC)

Background  

Exploitation of DNA-based analyses of microbial pathogens, and especially simultaneous typing of several virulence-related genes in bacteria is becoming an important objective of public health these days.     

Integration of molecular biology tools for identifying promoters and genes abundantly expressed in flowers of Oncidium Gower Ramsey

Background  

Orchids comprise one of the largest families of flowering plants and generate commercially important flowers. However, model plants, such as Arabidopsis thaliana do not contain all plant genes, and agronomic and horticulturally important genera and species must be individually studied.     

Use of historic metabolic biotransformation data as a means of anticipating metabolic sites using MetaPrint2D and Bioclipse

Background  

Predicting metabolic sites is important in the drug discovery process to aid in rapid compound optimisation. No interactive tool exists and most of the useful tools are quite expensive.     

Simplifying gene trees for easier comprehension

Background  

In the genomic age, gene trees may contain large amounts of data making them hard to read and understand. Therefore, an automated simplification is important.     

The TROVE module: A common element in Telomerase,Ro and Vault ribonucleoproteins

Background  

Ribonucleoproteins carry out a variety of important tasks in the cell. In this study we show that a number of these contain a novel module, that we speculate mediates RNA-binding.