共查询到20条相似文献,搜索用时 15 毫秒
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U. Hagen 《Radiation and environmental biophysics》1990,29(4):315-322
Summary Future aspects of molecular radiation biology may be envisaged by looking for unsolved problems and ways to analyse them. Considering the endpoints of cellular radiation effects as cell inactivation, chromosome aberrations, mutation and transformation, the type of DNA damage in the irradiated cell and the mechanisms of DNA repair as excision repair, recombination repair and mutagenic repair are essential topics. At present, great efforts are made to identify, to clone and to sequence genes involved in the control of repair of DNA damage and to study their regulation. There are close relationships between DNA repair genes isolated from various organisms, which promises fast progress for the molecular analysis of repair processes in mammalian cells. More knowledge is necessary regarding the function of the gene products, i.e. enzymes and proteins involved in DNA repair. Effort should be made to analyse the enzymatic reactions, leading to an altered nucleotide sequence, encountered as a point mutation. Mislead mismatch repair and modulation of DNA polymerase might be possible mechanisms.Paper given at the workshop Molecular Radiation Biology. German Section of the DNA Repair Network, München-Neuherberg, 21.–23.3.90 相似文献
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Subbaratnam Muthukrishnan Yasuyuki Arakane Qing Yang Chuan‐Xi Zhang Jianzhen Zhang Wenqing Zhang Bernard Moussian 《Archives of insect biochemistry and physiology》2018,98(2)
This microreview stems from the Second Symposium on Insect Molecular Toxicology and Chitin Metabolism held at Shanxi University in Taiyuan, China (June 27 to 30, 2017) at the institute for Applied Biology headed by Professor Enbo Ma and Professor Jianzhen Zhang. 相似文献
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Cirillo M De Santo NG Heer M Norsk P Elmann-Larsen B Bellini L Stellato D Drummer C 《Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology》2002,9(1):P193-P194
Proteinuria was hypothesized for space mission but research data are missing. Urinary albumin, as index of proteinuria, was analyzed in frozen urine samples collected by astronauts during space missions onboard MIR station and on ground (control). Urinary albumin was measured by a double antibody radioimmunoassay. On average, 24h urinary albumin was 27.4% lower in space than on ground; the difference was statistically significant. Low urinary albumin excretion could be another effect of exposure to weightlessness (microgravity). 相似文献
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Bermúdez LE 《Plastic and reconstructive surgery》2004,114(6):1687-9; author reply 1689
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Robinson OG 《Plastic and reconstructive surgery》2006,117(3):1040-1; author reply 1041
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Young LR 《Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology》1997,4(2):P21
The author examines the merits and problems associated with full-time rotation and intermittent G stimulation as weightlessness countermeasures during prolonged space flight. 相似文献
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Life sciences space missions. Overview 总被引:2,自引:0,他引:2
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Di-n-butyl phthalate and other dialkyl phthalates are used as carbon sources by three Nocardia sp. isolates; mono-n-butyl phthalate is used as a carbon source by an Arthrobacter sp. isolate and a Pseudomonas sp. isolate. The compounds were metabolized in these organisms by hydrolysis to the corresponding monoesters and free phthalic acid. Phthalic acid was then metabolized via protocatechuic acid by 3,4-dioxygenative ring cleavage. 相似文献
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The authors present their experience with 15 years of organizing cleft lip and palate surgical volunteer missions in Latin America. The history, basic principles, and objectives of Operation San Jose, a volunteer goodwill program from Christus St.Joseph Hospital in Houston, Texas, are covered. This report addresses the different problems encountered and solutions found. Following the principles set by Operation San Jose, CIRPLAST is a Peruvian foundation for plastic surgery that travels to remote areas in Peru, operating on patients with cleft lip and palate deformities. This report highlights the importance of working with local plastic surgeons and their residents, and emphasizes that the program should be organized by and the operations performed by accredited plastic surgeons and with the auspices and support of the national plastic surgery society and the local medical board. Operation San Jose promotes the creation of long-term benefits by offering a program to teach local surgeons cleft lip and palate repair techniques and to set up guidelines to organize local surgeons so that they can continue this effort by treating their own patients in their own countries. 相似文献
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I. B. Morukov M. P. Rykova E. N. Antropova T. A. Berendeeva S. A. Ponomarev B. V. Morukov 《Human physiology》2016,42(7):719-723
The results of studying the system of the osteoprotegerin/receptor activator of nuclear factor kappa-B ligand (OPG/RANKL) in 22 Russian cosmonauts after long-term (124–199 days) International Space Station missions are presented. It was found that early readaptation period is associated with changes in the serum concentrations of OPG and RANKL and the production rate of OPG and RANKL in phytohemagglutinin (PHA)-stimulated and non-stimulated mononuclear cells of peripheral blood in vitro. The extent of these changes varied in different subjects. Our data suggest that the OPG/RANKL cytokine system takes part in the processes of bone remodeling in cosmonauts after long-term missions. 相似文献
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