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Analysis of the AP-1 sites in the IL-2 promoter. 总被引:18,自引:0,他引:18
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Autoregulation of fos: the dyad symmetry element as the major target of repression. 总被引:46,自引:12,他引:34
H K?nig H Ponta U Rahmsdorf M Büscher A Sch?nthal H J Rahmsdorf P Herrlich 《The EMBO journal》1989,8(9):2559-2566
Fos and Jun co-operatively repress the fos promoter. Removal of all putative Fos/Jun binding sites from the fos promoter neither obliterates the repression by Fos/Jun in transient cotransfection experiments in NIH3T3 cells nor the turn-off kinetics of serum-induced fos expression in stably transfected NIH3T3 cells. The dyad symmetry element (DSE) suffices to subject a promoter to this type of repression. However, one of the putative Fos/Jun binding sites (-292 to -299 and thus located immediately adjacent to the DSE), determines the very low level of basal expression. 相似文献