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《Current biology : CB》2022,32(19):4314-4324.e7
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The active DNA demethylation in early embryos is essential for subsequent development. Although the zygotic genome is globally demethylated, the DNA methylation of imprinted regions, part of repeat sequences and some gamete-specific regions are maintained. Recent evidence has shown that multiple proteins and biological pathways participate in the regulation of active DNA demethylation, such as TET proteins, DNA repair pathways and DNA methyltransferases. Here we review the recent understanding regarding proteins associated with active DNA demethylation and the regulatory networks controlling the active DNA demethylation in early embryos. 相似文献
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The maternal‐zygotic transition and zygotic activation of the Mnemiopsis leidyi genome occurs within the first three cleavage cycles 
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下载免费PDF全文 Phillip L. Davidson Bernard J. Koch Christine E. Schnitzler Jonathan Q. Henry Mark Q. Martindale Andreas D. Baxevanis William E. Browne 《Molecular reproduction and development》2017,84(11):1218-1229
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《Cell Stem Cell》2022,29(3):449-459.e6
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Functional organisation of the genome during interphase 总被引：2，自引：0，他引：2