磺胺嘧啶银混悬液联合银锌霜分阶段疗法在大面积烧伤中的应用

目的:观察2008年1月至2010年12月期间98例TBSA大于35%的烧伤病人创面联合应用磺胺嘧啶银混悬液联合银锌霜的疗效.方法:以同期76例应用碘伏的病人作为对照,两组病人的平均年龄、烧伤面积、Ⅲ度面积无显著差别,用药方式均以半暴露为主.结果:磺胺嘧啶银混悬液联合银锌霜组能显著增加细菌转阴率,减少抗生素应用时间及植皮手术次数,缩短愈合时间.结论:磺胺嘧啶银混悬液联合银锌霜较碘伏能显著增加抗感染能力,有利于肉芽创面形成,为自行愈合或再次手术打下良好基础,值得应用.     

磺胺嘧啶银混悬液联合银锌霜分阶段疗法在大面积烧伤中的应用

目的：观察2008年1月至2010年12月期间98例TBSA大于35%的烧伤病人创面联合应用磺胺嘧啶银混悬液联合银锌霜的疗效。方法：以同期76例应用碘伏的病人作为对照,两组病人的平均年龄、烧伤面积、Ⅲ度面积无显著差别,用药方式均以半暴露为主。结果：磺胺嘧啶银混悬液联合银锌霜组能显著增加细菌转阴率,减少抗生素应用时间及植皮手术次数,缩短愈合时间。结论：磺胺嘧啶银混悬液联合银锌霜较碘伏能显著增加抗感染能力,有利于肉芽创面形成,为自行愈合或再次手术打下良好基础,值得应用。     

新型抗菌凝胶敷料治疗深II度烧伤创面的疗效评价

目的:评价新型抗菌凝胶敷料普朗特联合磺胺嘧啶银霜治疗深Ⅱ度烧伤创面的临床疗效和安全性。方法:采用前瞻性随机对照的方法将2015年3月至2016年5月来我科初次就诊的深Ⅱ度烧伤患者74例分为两组:试验组38例采用新型抗菌凝胶敷料普朗特联合磺胺嘧啶银霜治疗,对照组36例采用磺胺嘧啶银霜治疗。两组均采用规定的标准化创面处理方式,其余治疗均按常规进行。分别统计和比较两组的创面愈合时间、愈合率、创面细菌培养阳性率、换药时的疼痛程度,同时定期监测患者在用药期间有无实验室指标异常及不良反应的发生。结果:试验组创面愈合时间(21.11 3.13)d,明显短于对照组(25.28 4.50)d(P0.01)。治疗后7 d、14 d、21 d,试验组创面愈合率分别为(26.63 5.21)%、(63.32 5.32)%、(92.66 4.19)%,均显著高于对照组(P0.05)。治疗后7 d、14 d,试验组分别有5例(13.16%)和1例(2.63%)创面细菌培养阳性,明显低于对照组的12例(33.33%)和8例(22.22%)(P0.05)。治疗后7 d、14 d、21 d,试验组换药时的疼痛评分均明显低于对照组(P0.05)。两组治疗期间实验室检查指标均无异常波动,均未见明显不良反应。结论:新型抗菌凝胶敷料普朗特联合磺胺嘧啶银霜治疗深Ⅱ度烧伤创面能缩短愈合时间,提高愈合率,减少创面感染发生,减轻患者痛苦。     

抑菌生抗大鼠烫伤创面金葡菌感染的实验研究

将大白鼠致成10％的Ⅲ°烫伤,创面涂金黄色葡萄球菌造成感染的动物模型,然后分别值入BS_(224)菌制剂及磺胺嘧啶银霜(AG—SD),经痂下、肺、肝及心血细菌定量培养,进行对比分析。结果显示,抑菌生是强有力的生态抗菌制剂,对金葡菌具有较强的防治感染效果,疗效优于AG—SD。     

抑菌生防治大鼠烫伤创面大肠杆菌感染的实验研究

本实验将大白鼠背部烫伤后,用大肠杆菌涂抹创面,分别用BS_(224)菌(抑菌生)及AG—SD(磺胺嘧啶银霜)处理创面,以观察抑菌生对动物烫伤感染的防治效果。结果表明:抑菌生对有一定耐药性(但对AG—SD不耐药)的大肠杆菌引起的烫伤局部感染具有较强的防治功效,其作用和疗效优于AG—SD。     

磺胺嘧啶锌过敏1例报告

磺胺嘧啶锌是一种常用的烧伤外用药,适用于预防及治疗Ⅱ°、Ⅲ°烧烫伤继发创面感染,具有抗菌消炎、收敛之功效.但由于个体差异,有些患者涂抹后有不同程度的过敏症状,现将我院磺胺嘧啶锌过敏1例资料报告如下.     

两种湿敷护理法对眼镜蛇咬伤致局部溃疡的疗效比较

目的 探讨中华眼镜蛇咬伤致局部软组织肿胀坏死的有效护理方法.方法 收集2010年1月~2012年12月我科收治的60例中华眼镜蛇咬伤中毒患者的临床资料,按护理方法不同随机分为观察组和对照组各30例.观察组采取磺胺嘧啶银霜配合使用重组人表皮生长因子外用溶液(Ⅰ),对照组采取常规的护理措施即单纯使用40%硫酸镁甘油湿敷肿胀坏死处,观察比较两组病例开始消肿时间与完全消肿时间及止痛效果.结果 观察组患者肿胀开始消退和完全消退时间分别为(25.4±22.3)h、(98.1±20.5)h,止痛有效率为90%;对照组患者肿胀开始消退及完全消退时间分别为(45.6±32.1)h、(132.2±73.4)h,止痛有效率为60%.两组患者肿胀开始消退时间和完全消退时间比较,观察组明显短于对照组(P＜0.05),止痛有效率高于对照组.结论 磺胺嘧啶银霜配合使用重组人表皮生长因子外用溶液(Ⅰ)能有效促进中华眼镜蛇咬伤中毒致坏死皮肤的愈合.     

抑菌生防治大鼠烫伤创面绿脓杆菌感染的实验研究

通过对40只大鼠背部造成10％Ⅲ°烫伤感染绿脓杆菌后,分别用抑菌生和AG—SD霜进行生物拮抗试验。结果表明:抑菌生是强有力的生态抗菌制剂,对有耐药性但对AG—SD不产生耐药的绿脓杆菌引起的烧伤创面局部感染具有较强的防治效果,疗效优于AG—SD。     

枯草芽胞杆菌喷雾剂对家兔皮肤创伤愈合的影响

目的 :观察枯草芽胞杆菌喷雾剂对家兔皮肤创伤愈合的影响。方法 :采用家兔皮肤创伤为模型 ,连续给药 6 d,第 11天测定创面面积 ,并于第 17天记录创面愈合数。结果 :枯草芽胞杆菌喷雾剂高剂量组和磺胺嘧啶银组创面面积显著小于空白对照组 ( P<0 .0 5 ) ;枯草杆菌喷雾剂的愈合率显著高于空白对照组( P<0 .0 5 )。结论 :枯草芽胞杆菌喷雾剂能够缩小家兔创面愈合 ,增加创面愈合率     

银合欢叶提取物降血糖作用的实验研究

采用四氧嘧啶糖尿病小鼠模型及肾上腺素和葡萄糖引起的高血糖小鼠模型,观察银合欢叶提取物对实验动物的降血糖效果。银合欢叶提取物对四氧嘧啶所致糖尿病小鼠有明显的治疗效果,对肾上腺素和葡萄糖引起的高血糖模型小鼠有明显的降血糖作用,但对正常小鼠血糖无明显影响。     

Recent advances in the study of Kaposi's sarcoma-associated herpesvirus replication and pathogenesis

It has now been over twenty years since a novel herpesviral genome was identified in Kaposi's sarcoma biopsies. Since then, the cumulative research effort by molecular biologists, virologists, clinicians, and epidemiologists alike has led to the extensive characterization of this tumor virus, Kaposi's sarcoma-associated herpesvirus(KSHV; also known as human herpesvirus 8(HHV-8)), and its associated diseases. Here we review the current knowledge of KSHV biology and pathogenesis, with a particular emphasis on new and exciting advances in the field of epigenetics. We also discuss the development and practicality of various cell culture and animal model systems to study KSHV replication and pathogenesis.     

The structure, reproduction and taxonomy of Vidalia and Osmundaria (Rhodophyta, Rhodomelaceae)

Comprises species occurring mostly in subtidal habitats in tropical, subtropical and warm-temperate areas of the world. An analysis of the type species, V. spiralis (Sonder) Lamouroux ex J. Agardh, a species from Australia, establishes basic characters for distinguishing species in the genus. These characters are (1) branching patterns of thalli, (2) flat blades that may be spiralled on their axis, (3) width of the blade, (4) primary or secondary derivation of sterile and fertile branchlets and (5) position of sterile and fertile branchlets on the thalli. Application of the latter two characters provides an important basic method for separation of species into three major groups. Osmundaria , a genus known only in southern Australia, was studied in relation to Vidalia , and its separation from the Vidalia assemblage is not accepted. Species of Vidalia therefore are transferred to the older genus name, Osmundaria. Two new species, Osmundaria papenfussii and Osmundaria oliveae are described from Natal. Confusion in the usage of the epithet, Vidalia fimbriala Brown ex Turner has been clarified, and Vidalia gregaria Falkenberg, described as an epiphyte on Osmundaria pro/ifera Lamouroux, is revealed to be young branches of the host, Osmundaria prolifera.     

New or rare chromosome counts in Artemisia L. (Asteraceae, Anthemideae) and related genera from Kazakhstan

Fifteen chromosome counts of six Artemisia taxa and one species of each of the genera Brachanthemum, Hippolytia, Kaschgaria, Lepidolopsis and Turaniphytum are reported from Kazakhstan. Three of them are new reports, two are not consistent with previous counts and the remainder are confirmations of very scarce (one to four) earlier records. All the populations studied have the same basic chromosome number, x = 9, with ploidy levels ranging from 2x to 6x. Some correlations between ploidy level, morphological characters and distribution are noted.     

肝癌中HBV和HCV基因和抗原的分布及意义

采用原位分子杂交方法检测HCV RNA及HBV X基因;采用免疫组织化学方法研究HCV核心抗原,非结构区C33c抗原及HBxAg在肝细胞肝癌中的定位及分布.结果表明(1)HCV RNA、HBV X基因在肝细胞肝癌组织检出率分别为40%(55/136)和82%(112/136).HCV RNA定位于癌细胞的胞浆内,阳性细胞呈散在、灶状及弥漫分布三种形式;HBV X基因在肝癌细胞中的分布呈胞浆型、核型及核浆型,阳性细胞也呈上述三种分布形式;(2)HCV C33c抗原、核心抗原在肝细胞肝癌中的阳性率为81%(133/164)及86%(141/164).C33c抗原定位于癌细胞及肝细胞的胞浆内;核心抗原既定位于癌细胞核中,又可定位于胞浆中.C33c抗原阳性细胞以灶状分布为主;而核心抗原阳性细     

Selection with two alleles and complete dominance

For a plant selection model with frequency-independent viabilities, fertilities and selfing rates, it is shown that apart from global fixation, for certain parameter combinations a protected polymorphism and facultative fixation (either allele may become fixed according to initial frequencies) may both occur. Facultative fixation requires different selling rates for the dominant and recessive type. Protection of the polymorphism requires resource allocation for male and female function. In this connection the problem of purely genetically caused population extinction is discussed.
For general frequency dependence and regular segregation, the chances for establishment of a completely recessive gene are compared to those of a completely dominant gene. It is proven that the process of establishment of the recessive gene, despite a fitness advantage, may be considerably endangered by drift effects if random mating prevails. The recessive gene may reach the same effectivity in establishment as a dominant gene, only if the recessive homozygote mates exclusively with its own type during the period of establishment.