Mass Customization: Metrics and Modularity

Mass customization as a competitive strategy is getting progressively increasing attention in business and academic arenas due to its high potential to provide sustained strategic advantage in a unique fashion. It is well documented that a manufacturing company competes with others in its industry on five dimensions: Price, quality, flexibility, delivery, and service. According to the existing literature, mass customization provides significant strategic advantage in two of these dimensions—price and customization. We, however, argue that when properly implemented, the cellular manufacturing structure associated with the appropriate implementation of mass customization strategy, provides additional competitive value in quality and delivery. Furthermore by virtue of the customer co-design as an integral aspect of mass customization, customer satisfaction also improves under this strategy. Mass customization strategy, therefore, provides competitive advantage in all five competitive dimensions simultaneously—a truly unique strategic accomplishment. We also propose, in this paper, new metrics for mass customization strategy that measure the “mass” as well as the “customization” aspects of this strategy. Finally, we describe in the clearest terms the modus operandi of modularity in product design and the role it plays in bringing about high levels of customization on one hand and economies of scale at component level, on the other. We conclude with remarks that underscore the need for conducting research in the areas at the interface of mass customization and supply chain management.     

Measuring the effectiveness of a mass customization and personalization strategy: a market- and organizational-capability-based index

The research of Kumar (Int J Flex Manuf Syst 16(4):287–312, 2004) is expanded to develop a methodology that measures the effectiveness of a mass customization and personalization strategy using a mass customization and personalization effectiveness index. This index extends Kumar (2004) in three significant ways: (1) it encompasses both service and manufacturing companies, (2) the assessment of product customization considers that customers assign different weights to different product features, and (3) the index captures the impact of both market perception and system capabilities. Three different measures are proposed. Which is appropriate should be a function of a particular company’s parameters. The circumstances under which each measure is best is a subject for future research. The validation and reliability of this index and these measures are also issues that should be addressed by future research.     

From mass customization to mass personalization: a strategic transformation

Business and operations strategists have long sought to formulate strategies that would serve profitably for a market of one. Two decades after its conception, there is growing evidence that mass customization strategy is transforming into a mass personalization strategy, making the market of one a reality, at least in select industries. The degree of transformation of a company depends on the extent to which its product is soft, i.e., can be produced electronically. Thus, at the lower end of the personalization spectrum are manufacturing companies engaged in producing hard, configurable products, while on the high end of the spectrum are service companies whose product can be totally configured and delivered electronically. The underlying factors that are enabling this transformation, in our view, are: (1) development of information technologies such as peer to peer (P2P), business to consumer (B2C), and Web 2.0, (2) near-universal availability of the Internet, (3) customer willingness and preparedness to be integrated into the process of product co-design and co-creation, (4) modern manufacturing systems, such as flexible manufacturing and, of course, (5) mass customization tools such as modularity and delayed differentiation, which help reduce manufacturing cost and cycle times and (6) deployment of customer-satisfaction-specific software called customer relationship management (CRM) to engender customer retention. Due to the importance and strategic success of affordable personalization, this issue is dedicated to that theme. The articles included in this issue would, I believe, serve as significant decision support mechanisms for companies pursuing a mass customization and personalization strategy. In addition to providing a brief perspective on articles included in this issue, we also summarize the state of the art of mass customization research.     

Mass customization research: trends,directions, diffusion intensity,and taxonomic frameworks

Mass customization (MC) as a business strategy is designed to simultaneously compete on two rival competitive priorities—the price and customization level of a product. MC academics and experts have gone a step further. They suggest that MC is a unique strategy whose implementation promises across-the-board improvement in all four of the competitive priorities (price, quality, flexibility, and speed) simultaneously. Its growing adoption by businesses in recent years, the steep rise in success stories associated with MC, and the voluminous body of publications in a short period of its existence have created a need to study the directions, trends, application potential, and research strategies embedded in these publications. Accordingly, this paper studies and analyzes the trends and directions of the research published in 1,124 MC publications that have appeared in journals and magazines since the inception of the term mass customization in 1987 by Stan Davis in his classic book Future Perfect. Statistical trend analyses are conducted to study the vitality and health of the field of MC using number of publications and number of publication outlets and their respective trends. The publication outlet data conform to an S curve, establishing maturity of the MC field. The publication data show that the MC field has passed through four stages of growth: incubation or slow (1987–1992), exponential (1993–2003), stable and matured (2003–2005). There is a slight dip in 2006 in terms of publication outlets; there are, however, confirmatory factors that indicate that the dip in 2006 may be an outlier. This paper also suggests developing a clear understanding of the value and type of research embodied in MC publications through three types of taxonomic analyses. The frameworks for all three taxonomies are set forth, two of which have been previously employed in other areas of OR/MS (Reisman and Kirschnik, Oper Res 42(4):577–588, 1994; Oper Res 43(5):731–740, 1995): The first taxonomic framework first classifies the paper as a theory paper or an application paper. At the second stage, the application content of the publication is determined based on a five-point scale ranging from simple modeling of the real world to bona fide real-world application. The second taxonomic framework suggests usage of a taxonomy comprised of seven distinct types of research strategies. The former analysis provides important information about the application worthiness of the MC publications and hence their usefulness to the real world. The second analysis provides information about the type of research strategies used by MC researchers, which, in turn, allows drawing conclusions about the quality and rigor of such research. The third taxonomic framework suggested recommends classification of all publications among multi-level containers based on the disciplines that intersect with MC and their branches.     

Defects tracking matrix for mass customization production based on house of quality

The vision of mass customization has driven a movement toward low volume, high variety mass customization production (MCP) at low price. However, defect identification and defect tracking in such systems are extremely difficult because of the frequent reconfiguration needed by the number of different part types and the interruption of the information flow about quality with each reconfiguration of the system. It is important to quickly rebuild quality information flow with MCP system’s reconfiguration synchronously. This paper introduces a defect tracking method based on Quality Function Deployment for every MCP system module. A defects tracking matrix (DTM) based on the House of Quality directly connects manufacturing technologies with quality defects inside a MCP module. Each MCP reconfiguration requires the DTMs’ rearrangement and DTM-chain is proposed. A dynamic reconstructing algorithm synchronizes the DTM-chain with each MCP reconfiguration. A case study demonstrates the usefulness of the DTM and DTM-chain.     

A dynamic heuristic-based algorithm to part input sequencing in flexible manufacturing systems for mass customization capability

In the increasingly competitive global markets, enterprises face challenges in responding to customer orders quickly, as well as producing customized products cost-effectively. This paper proposes a dynamic heuristic-based algorithm for the part input sequencing problem of flexible manufacturing systems (FMSs) in a mass customization (MC) environment. The FMS manufactures a variety of parts, and customer orders arrive dynamically with order size as small as one. Segmental set functions are established in the proposed algorithm to apply the strategy of dynamic workload balancing, and the shortest processing time (SPT) scheduling rule. Theoretical analysis is performed and the effectiveness of the algorithm in dynamic workload balancing under the complex and dynamic environment is proven. The application of the algorithm is illustrated by an example. The potential of its practical applications to the FMSs in make-to-order (MTO) supply chains is also discussed. Further research is provided.     

Mass Customization in Videotape Duplication and Conversion: Challenges of Flexible Duplication Systems,Fast Delivery,and Electronic Service

With the emergence of electronic commerce technology, marketers gained new methods for personalizing electronic advertisements, automating marketing research, and customizing product designs. These developments suggest that production operations also must be redesigned to support contemporary marketing objectives via mass customization. Yet, operations management research historically has focused on mass production systems buffering the customer from production operations. As such, the literature provides relatively few insights about managing mass customization operations. Thus, in this paper, we consider a previously unexamined type of mass customization production operations. The paper presents a case study of a manufacturer's videotape duplication and conversion system, consisting of a flexible network of heterogeneous, parallel machines used to duplicate and convert videotapes and other multimedia. We describe the characteristics of this flexible duplication system, discuss parallels between these systems and mass customization, and identify issues regarding flexibility, speed of delivery, and electronic service.     

The Scope of Public Discourse Surrounding Proposition 71: Looking Beyond the Moral Status of the Embryo

Human embryonic stem cell research has generated considerable discussion and debate in bioethics. Bioethical discourse tends to focus on the moral status of the embryo as the central issue, however, and it is unclear how much this reflects broader community values and beliefs related to stem cell research. This paper presents the results of a study which aims to identify and classify the issues and arguments that have arisen in public discourse associated with one prominent policy episode in the United States: the 2004 Californian Stem Cell Research and Cures Initiative (also known as Proposition 71). The findings show that public discourse about Proposition 71 is characterised by a broader range of issues than those usually addressed in scholarly publications and public policy documents. While attention to the moral status of the embryo is an important issue in stem cell research, making it the main focus of public discourse has a polarising effect. This also limits opportunities to identify shared values, understand how political alliances are forged, and develop social consensus. Implications for future research and policy are discussed.     

Neural melanocortin receptors in obesity and related metabolic disorders

Obesity is a global health issue, as it is associated with increased risk of developing chronic conditions associated with disorders of metabolism such as type 2 diabetes and cardiovascular disease. A better understanding of how excessive fat accumulation develops and causes diseases of the metabolic syndrome is urgently needed. The hypothalamic melanocortin system is an important point of convergence connecting signals of metabolic status with the neural circuitry that governs appetite and the autonomic and neuroendocrine system controling metabolism. This system has a critical role in the defense of body weight and maintenance of homeostasis. Two neural melanocortin receptors, melanocortin 3 and 4 receptors (MC3R and MC4R), play crucial roles in the regulation of energy balance. Mutations in the MC4R gene are the most common cause of monogenic obesity in humans, and a large literature indicates a role in regulating both energy intake through the control of satiety and energy expenditure. In contrast, MC3Rs have a more subtle role in energy homeostasis. Results from our lab indicate an important role for MC3Rs in synchronizing rhythms in foraging behavior with caloric cues and maintaining metabolic homeostasis during periods of nutrient scarcity. However, while deletion of the Mc3r gene in mice alters nutrient partitioning to favor accumulation of fat mass no obvious role for MC3R haploinsufficiency in human obesity has been reported. This article is part of a Special Issue entitled: Modulation of Adipose Tissue in Health and Disease.     

Practical considerations in clinical strategy to support the development of injectable drug-device combination products for biologics

The development of an injectable drug-device combination (DDC) product for biologics is an intricate and evolving process that requires substantial investments of time and money. Consequently, the commercial dosage form(s) or presentation(s) are often not ready when pivotal trials commence, and it is common to have drug product changes (manufacturing process or presentation) during clinical development. A scientifically sound and robust bridging strategy is required in order to introduce these changes into the clinic safely. There is currently no single developmental paradigm, but a risk-based hierarchical approach has been well accepted. The rigor required of a bridging package depends on the level of risk associated with the changes. Clinical pharmacokinetic/pharmacodynamic comparability or outcome studies are only required when important changes occur at a late stage. Moreover, an injectable DDC needs to be user-centric, and usability assessment in real-world clinical settings may be required to support the approval of a DDC. In this review, we discuss the common issues during the manufacturing process and presentation development of an injectable DDC and practical considerations in establishing a clinical strategy to address these issues, including key elements of clinical studies. We also analyze the current practice in the industry and review relevant and status of regulatory guidance in the DDC field.     

Virtual manufacturing cells: A taxonomy of past research and identification of future research issues

This paper reviews prior research in the area of virtual manufacturing cells. A virtual manufacturing cell (VMC) is a group of resources that is dedicated to the manufacturing of a part family, though this grouping is not reflected in the physical structure of the manufacturing system. Distinguishing such groups in the production control system offers the possibility of achieving the advantages of cellular manufacturing in non-cellular manufacturing systems. The advantages may include improved flow performance, higher efficiency, simplified production control, and better quality. The paper reviews the previous publications on virtual manufacturing cells, to determine the methods and scope of present research. This results in a comprehensive framework which identifies the underlying principles of VMCs and classifies the different VMC concepts. It is shown that virtual manufacturing cells can significantly improve the performance of manufacturing systems. Based on the comprehensive review, many future research issues and high-impact research areas are also identified.     

Use of Monte Carlo simulations for improved facility fit planning in downstream biomanufacturing and technology transfer

Biologics manufacturing is capital and consumable intensive with need for advanced inventory planning to account for supply chain constraints. Early-stage process design and technology transfer are often challenging due to limited information on process variability regarding bioreactor titer, process yield, and product quality. Monte Carlo (MC) methods offer a stochastic modeling approach for process optimization where probabilities of occurrence for process inputs are incorporated into a deterministic model to simulate more likely scenarios for process outputs. In this study, we explore MC simulation-based design of a monoclonal antibody downstream manufacturing process. We demonstrate that this probabilistic approach offers more representative outcomes over the conventional worst-case approach where the theoretical minimum and maximum values of each process parameter are used without consideration for their probability of occurrence. Our work demonstrates case studies on more practically sizing unit operations to improve consumable utilization, thereby reducing manufacturing costs. We also used MC simulations to minimize process cadence by constraining the number of cycles per unit operation to fit facility preferences. By factoring in process uncertainty, we have implemented MC simulation-based facility fit analyses to efficiently plan for inventory when accounting for process constraints during technology transfer from lab-scale to clinical or commercial manufacturing.     

An African theory of bioethics: reply to MacPherson and Macklin

In a prior issue of Developing World Bioethics, Cheryl Macpherson and Ruth Macklin critically engaged with an article of mine, where I articulated a moral theory grounded on indigenous values salient in the sub-Saharan region, and then applied it to four major issues in bioethics, comparing and contrasting its implications with those of the dominant Western moral theories, utilitarianism and Kantianism. In response to my essay, Macpherson and Macklin have posed questions about: whether philosophical justifications are something with which bioethicists ought to be concerned; why something counts as 'African'; how medicine is a moral enterprise; whether an individual right to informed consent is consistent with sub-Saharan values; and when thought experiments help to establish firm conclusions about moral status. These are important issues for the field, and I use this reply to take discussion of them a step or two farther, defending my initial article from Macpherson's and Macklin's critical questions and objections.     

覆膜对高寒阴湿区当归土壤质量、植株生长和杂草发生的影响

在当归优质产区设置起垄覆膜穴栽(LS)、膜侧开沟斜栽(MC)和露地开沟斜栽(LD)3种种植方式,分析覆膜对移栽当归植株生长动态、抽薹率、土壤特性、酶活性及杂草密度和防效的影响,以期为全面评估优质产区当归覆膜种植技术提供理论基础。结果表明:与LD相比,LS和MC表层土壤有机质含量分别提高了4.4%和14.3%,MC达到显著水平;土壤容重分别显著降低了11.6%和8.5%,土壤pH值显著降低了4.6%和1.7%,两种覆膜方式均显著提高了土壤蔗糖酶、磷酸酶和脲酶活性,但对过氧化氢酶活性有一定的抑制作用。覆膜提高了当归种苗移栽后的返青速度、田间早期抽薹率和药材个体质量。其中,MC返青最快、最整齐,返青率最高;LS抽薹率最高;MC和LS单根药材鲜质量分别比LD显著增加20.4%和58.4%。MC和LS当归田杂草密度分别比LD显著降低了34.0%和25.8%,MC株防效和鲜质量防效分别较LS显著提高21.7%和63.4%。覆膜种植改善了当归根系的生长环境,降低了田间杂草密度,提高了杂草防效,促进了当归生长发育进程和药材物质积累,对种苗移栽后早期抽薹的发生有一定的促进作用。     

我国医疗质量研究30年的历史回顾与基本特征

医药卫生体制改革已走过30年光辉历程。利用CNKI检索系统,采取文献回顾方法,首次全面系统回顾医疗质量研究状况。医疗质量研究可以划分为阶段明显的3个时期,每个历史阶段的基本特征明显。研究发现,卫生质量研究的主题是医疗质量。医疗质量议题由少到多,由冷到热,由边缘到主流,成为卫生政策与医院管理的核心议题。基本结论是,卫生质量与医疗质量的研究目的、动力源泉、研究范围、研究议题、研究方法和理论视角亟待结构调整,以回应国人不断提高的健康需要,深化医药卫生体制改革,加强医学人文关怀,建立卫生保健财政制度,构建和谐医患关系。     

Aligning demand and supply flexibility in custom product co-design

Flexibility of supply and demand is essential for successful implementation of a mass customization strategy that delivers sustained competitive advantage. Supply flexibility, i.e., a choice of alternative products designed to perform the same basic function, is made possible by the range of capabilities available in flexible and agile manufacturing systems and in supply chains. Demand flexibility is derived from the degree to which a customer is willing to compromise on product features or performance levels in order to meet budgetary (reflected in price) or schedule (reflected in delivery) constraints. Flexibility of both supply and demand can have significant strategic and financial value if they are properly aligned. However, customers are mostly unaware of mapping of demand flexibility on to supply flexibility and its impact on production cost and time. Recent advances in information technology have made it possible to co-design a product that involves customer on one end and the manufacturer on the other. This creates an aura and an opportunity where a middle ground between the supply and demand flexibility can be explored and a “deal” can be struck where both parties settle for a product that is beneficial to both through a negotiated settlement. In this paper, we develop a framework for such negotiations. The customer requirements are treated as a range of negotiable options instead of a set of fixed inputs. Demand and supply for customization is then matched by aligning the flexibility of manufacturing systems with customers’ requirement options. Based on this framework, a negotiation scheme is developed to assist customers and manufacturers in exploring and utilizing demand and supply flexibility information in co-design. The negotiation scheme is formulated using goal programming. Finally, an interactive problem-solving procedure is developed and implemented with an illustrative example.     

Interview with Sydney Brenner

The following text is an edited version of a recent interview with Sydney Brenner who has been at the forefront of many developments in molecular biology since the 1950s. It provides a participant’s view on current issues in the history and epistemology of molecular biology. The main issue raised by Brenner regards the relation of molecular biology to the new field of systems biology. Brenner defends the original programme of molecular biology—the molecular explanation of living processes—that in his view has yet to be completed. The programme of systems biology in contrast he views as either trivial or as not achievable since it purports to deal with inverse problems that are impossible to solve in complex living systems. Other issues covered in the conversation concern the impact of the human genome sequencing project, the commercial turn in molecular biology and the contested disciplinary status of the science.     

Regulation of lean mass, bone mass, and exercise tolerance by the central melanocortin system

Signaling via the type 4-melanocortin receptor (MC4R) is an important determinant of body weight in mice and humans, where loss of function mutations lead to significant obesity. Humans with mutations in the MC4R experience an increase in lean mass. However, the simultaneous accrual of fat mass in such individuals may contribute to this effect via mechanical loading. We therefore examined the relationship of fat mass and lean mass in mice lacking the type-4 melanocortin receptor (MC4RKO). We demonstrate that MC4RKO mice display increased lean body mass. Further, this is not dependent on changes in adipose mass, as MC4RKO mice possess more lean body mass than diet-induced obese (DIO) wild type mice with equivalent fat mass. To examine potential sources of the increased lean mass in MC4RKO mice, bone mass and strength were examined in MC4RKO mice. Both parameters increase with age in MC4RKO mice, which likely contributes to increases in lean body mass. We functionally characterized the increased lean mass in MC4RKO mice by examining their capacity for treadmill running. MC4R deficiency results in a decrease in exercise performance. No changes in the ratio of oxidative to glycolytic fibers were seen, however MC4RKO mice demonstrate a significantly reduced heart rate, which may underlie their impaired exercise performance. The reduced exercise capacity we report in the MC4RKO mouse has potential clinical ramifications, as efforts to control body weight in humans with melanocortin deficiency may be ineffective due to poor tolerance for physical activity.     

Clonal plants: beyond the patterns—ecological and evolutionary dynamics of asexual reproduction

More than 25 years have passed since publication of the first comprehensive multi-authored landmark volume on the population biology and evolution of clonal organisms (Jackson et al. 1985). Since then, no less than eight symposium volumes or special issues have appeared in scientific journals reporting on advances in the field of clonal plant research, indicating that the study of clonal organisms has remained an important topic in ecological research. The three most recent overviews were published in special issues of this journal (Stuefer et al. 2000; Tolvanen et al. 2004; Sammul et al. 2008), and these are now supplemented with a fourth special issue of Evolutionary Ecology. The articles published here reflect some of the most important contributions to a workshop on clonal plant biology held in Leuven (Belgium) in July 2009 and they illustrate some major advances that have been made over the last few years. In the following paragraphs, we first summarize some representative contributions to the current issue, and second, we put forward some personal ideas about promising and underexplored research lines in clonal plant research.