共查询到20条相似文献,搜索用时 156 毫秒
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Matthias Hackl Stefan Brunner Klaus Fortschegger Carina Schreiner Lucia Micutkova Christoph Mück Gerhard T. Laschober Günter Lepperdinger Natalie Sampson Peter Berger Dietmar Herndler‐Brandstetter Matthias Wieser Harald Kühnel Alois Strasser Mark Rinnerthaler Michael Breitenbach Michael Mildner Leopold Eckhart Erwin Tschachler Andrea Trost Johann W. Bauer Christine Papak Zlatko Trajanoski Marcel Scheideler Regina Grillari‐Voglauer Beatrix Grubeck‐Loebenstein Pidder Jansen‐Dürr Johannes Grillari 《Aging cell》2010,9(2):291-296
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Differential expression of microRNAs let‐7a,miR‐125b,miR‐100, and miR‐21 and interaction with NF‐kB pathway genes in periodontitis pathogenesis 下载免费PDF全文
Priyanka Venugopal Teena Koshy Vamsi Lavu Suresh Ranga Rao Selvaraj Ramasamy Samyuktha Hariharan Vettriselvi Venkatesan 《Journal of cellular physiology》2018,233(8):5877-5884
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Circulating microRNAs,miR‐92a,miR‐100 and miR‐143, as non‐invasive biomarkers for bladder cancer diagnosis 下载免费PDF全文
Tarek Kamal Motawi Sherine Maher Rizk Taghreed Mahmoud Ibrahim Ihab Abdel‐Rahman Ibrahim 《Cell biochemistry and function》2016,34(3):142-148
The application of microRNAs (miRNAs) as potential biomarkers and therapy targets has been widely investigated in many kinds of cancers. Recent advantages of serum miRNAs open a new realm of possibilities for non‐invasive diagnosis and prognosis of bladder cancer (BC). The aim of our study was to identify plasma miR‐92a, miR‐100 and miR‐143 expression signatures in patients with BC to introduce new markers for establishing BC diagnosis and prognosis. Blood samples were collected from 70 BC patients and 62 controls. An expression of three target miRNAs (miR‐92a, miR‐100 and miR‐143) was measured using quantitative real‐time PCR method. Results were correlated with clinicopathological data and analysed. Plasma levels of miR‐92a, miR‐100 and miR‐143 were significantly lower in BC patients than in control group. Receiver operator characteristic analysis revealed that the sensitivity and specificity values of miR‐92a were 97·1% and 76·7%, respectively, with a cut‐off value of 0·573. The sensitivity and specificity values of miR‐100 were 90% and 66·7%, respectively, with a cut‐off value of 0·644. The sensitivity and specificity values of miR‐143 were 78·6% and 93·3%, respectively, with a cut‐off value of 0·164. This study explores the existence of specific plasma miRNAs as early diagnostic biomarkers for BC in Egyptian patients; and these findings suggest that plasma miR‐92a, miR‐100 and miR‐143 could be promising novel circulating biomarkers in clinical detection of BC. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
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Induced miR‐99a expression represses Mtor cooperatively with miR‐150 to promote regulatory T‐cell differentiation 下载免费PDF全文
Sebastian C Warth Kai P Hoefig Anian Hiekel Sonja Schallenberg Ksenija Jovanovic Ludger Klein Karsten Kretschmer K Mark Ansel Vigo Heissmeyer 《The EMBO journal》2015,34(9):1195-1213
Peripheral induction of regulatory T (Treg) cells provides essential protection from inappropriate immune responses. CD4+ T cells that lack endogenous miRNAs are impaired to differentiate into Treg cells, but the relevant miRNAs are unknown. We performed an overexpression screen with T‐cell‐expressed miRNAs in naive mouse CD4+ T cells undergoing Treg differentiation. Among 130 candidates, the screen identified 29 miRNAs with a negative and 10 miRNAs with a positive effect. Testing reciprocal Th17 differentiation revealed specific functions for miR‐100, miR‐99a and miR‐10b, since all of these promoted the Treg and inhibited the Th17 program without impacting on viability, proliferation and activation. miR‐99a cooperated with miR‐150 to repress the expression of the Th17‐promoting factor mTOR. The comparably low expression of miR‐99a was strongly increased by the Treg cell inducer “retinoic acid”, and the abundantly expressed miR‐150 could only repress Mtor in the presence of miR‐99a. Our data suggest that induction of Treg cell differentiation is regulated by a miRNA network, which involves cooperation of constitutively expressed as well as inducible miRNAs. 相似文献
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Circulating miR‐22, miR‐24 and miR‐34a as Novel Predictive Biomarkers to Pemetrexed‐Based Chemotherapy in Advanced Non‐Small Cell Lung Cancer 下载免费PDF全文
Tindara Franchina Valeria Amodeo Giuseppe Bronte Giuseppina Savio Giuseppina R.R. Ricciardi Maria Picciotto Antonio Russo Antonio Giordano Vincenzo Adamo 《Journal of cellular physiology》2014,229(1):97-99
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Keivan Mobini Gholamhossein Tamaddon Reza Fardid Majid Keshavarzi Afshin Mohammadi‐Bardbori 《Journal of biochemical and molecular toxicology》2019,33(6)
The underlying functions of miR‐206, miR‐133a, miR‐27b, and miR‐21, and their link to the estrogen receptor alpha (ERα) and aryl hydrocarbon receptor (AhR) signaling pathways remain largely unexplored. In this study, we detect the expression of miR‐206, miR‐133a, miR‐27b, and miR‐21 in MCF‐7 through quantificational real‐time polymerase chain reaction assay along with the activation/inhibition of ERα and AhR receptors. Aside from this, cell proliferation and migration as well as AhR‐dependent CYP1A1 enzyme activity were measured. Here, we found that the forced increased expression of miR‐206, miR‐133a, and miR‐27b were closely associated with the suppression of MCF‐7 cell proliferation and migration. The anti‐proliferative‐metastatic effect of miR‐206, miR‐133a, and miR‐27b was probably mediated by targeting the ERα and AhR signaling pathways. Considered together, our study indicated that the overexpression of miR‐206, miR‐133a, and miR‐27b might be potential biomarkers for prognosis and therapeutic strategies in breast cancer. 相似文献
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