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Summary DNA markers in the pericentromeric region of human chromosome 21 have shown linkage to a gene for Familial Alzheimer disease (FAD; St. George Hyslop et al. 1987). The limited informativeness of probes for the loci D21S13 and D21S16 have hindered precise mapping of the FAD locus and analysis of non-allelic heterogeneity in FAD (Schellenberg et al. 1988; St. George-Hyslop et al. 1987). We recently described a new EcoRII polymorphism at the D21S13 locus that was very informative in a large FAD pedigree (Pulst et al. 1990a, b). We now report another polymorphism for the D21S13 locus that further increases the informativeness of this locus. 相似文献
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Summary A new RFLP is described at the D21S16 locus formerly linked to familial Alzheimer's disease. 相似文献
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S. Abdelhak J. Melki M.F. Bachelot P. Burlet P. Sheth J. Frzal A. Munnich 《Nucleic acids research》1990,18(18):5580
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