Archaeology of the Mcclure Site (39Hu7) and the Protohistoric Period in the Big Bend Region of South Dakota

Abstract

The McClure site is an Arikara village in central South Dakota dating from the Protohistoric period at the end of the 17th Century. The settlement consisted of at least 35 earth lodges, was unfortified, and was located below the bluffs on the Missouri River bottoms a few feet above the floodplain. Excavations in two houses, one of them a specialized small lodge, produced artifacts typical of the Felicia phase of the Big Bend region, including ceramics largely assignable to the lona and Talking Crow ware categories, but with a small element of Stanley ware. Because of the location of McClure in the Bad River district around the decade A.D. 1690-1700 and other factors, it is thought to have played some role in the emerging Bad River Phase     

The Identity and Demography of the Plains-Ojibwa

Abstract

One of the largest Indian tribes of the northern praries is the Bungi or Plains-Ojibwa, Despite their importance in the historic period they go unmentioned in most histories. In large part this is due to semantic confusion in their identification by writers and official agencies.

In language, social organization, art, ceremonial, and costume the Plains Ojibwa is a distinct ethnic group. Although they are descended from Woodland groups, 150 years of separate political and cultural existence has made them a distinct tribe.

The gradual migration of small Ojibwa groups unto the Plains began near the end of the 18th century. By 1800 those living west of the Red River of the North were beginning to be thought of as a distinct group. However, confusion as to their irlentity has persisted.

At present 2 ethnic groups make up the Plains-Ojibwa, a “full-blood” minority group and a metis group which, although basically PlainsOjibwa with some Cree admixture, has a large amount of French as well as other European blood.     

Mass Spectrometry and Proteomics 2018: the Mass Spectrometry Society of Japan,Japanese Proteomics Society,and Asia-Oceania Human Proteome Organization

ABSTRACT

Introduction: The mass spectrometry society of Japan, Japanese proteomics society, and Asia–Oceania human proteome organization held the conference ‘Mass Spectrometry and Proteomics 2018’ in Osaka, Japan, on May 15–18, 2018. This international conference focused on cutting edge technologies and their applications in a variety of research fields such as agriculture, material science, environmental factors, and clinical applications. An overview of the conference and a summary of the major lectures are reported here.

Expert commentary: The meeting will facilitate the development of fundamental technologies and the multi-disciplinary applications of proteomics.     

Evaluating the Effects of Separate and Concomitant Use of MK-2206 and Salinomycin on Prostate Cancer Cell Line

Background:Prostate cancer is known as one of the most prevalent health disorders in the male population globally. The aim of the current study was to evaluate the effects of separate and concomitant use of MK-2206 and salinomycin on prostate cancer cell line.Methods:The antitumor potential of separate and concomitant use of MK-2206 and salinomycin was evaluated in a panel of prostate cancer cell line (PC-3). To get insights into the underlying mechanism of action, different assays including the rate of apoptosis, cell viability, and gene expression were performed in treated prostate cancer cells.Results:A significant reduction was detected in the viability percentage of prostate cancer cells (p< 0.001) and the rate of Akt expression (p< 0.001) in all salinomycin, MK-2206, and salinomycin+MK-2206 groups compared to the negative control group. Furthermore, in comparison with the negative control group, there was a notable increase in both the rate of Bad expression (p< 0.001) and prostate cancer cells apoptosis after salinomycin, MK-2206, and salinomycin+MK-2206 treatments. Moreover, the concomitant use of salinomycin+MK-2206 revealed synergistic improvements regarding the viability of prostate cancer cells and the rate of the Akt and Bad expressions compared to the separate administration of salinomycin and MK-2206 (all p< 0.05)Conclusion:The findings of the present study may contribute to improving the efficacy of the therapies regarding the management of prostate cancer and providing a beneficial strategy in clinical trials.Key Words: Apoptosis, Gene Expression, MK 2206, Prostatic Neoplasms, Salinomycin     

Assessment of heavy-metal pollution in three different Indian water bodies by combination of multivariate analysis and water pollution indices

Abstract

Water quality is a big concern for the humankind as it is the most important natural resource. However, the non-controlled growth of rural and urban areas in rapidly developed countries such as India is affecting water quality. In this research, we pretend to assess and demonstrate the heavy-metal status of three different water bodies of Indus, Beas and Sutlej Rivers and Harike Wetland. Data on water quality from 2013 to 2017 were analyzed through multivariate statistic techniques (cluster analysis – CA – and principal component analysis – PCA) and compared among them using public water pollution indexes. The results of CA and PCA showed that Sutlej River and Harike Wetland are included in the same group, whereas Beas River formed a separate one. This may be due to the high content of Pb, Cu, and Zn in these water bodies as compared with Beas River. The Pb content of all the water bodies exceeded the limit for EPR, BIS and WHO guidelines for drinking water. The heavy-metal pollution index was also applied to the contents of different heavy metals to find which water body is more polluted, and from their results, it was found that Harike Wetland and Sutlej River are critically polluted with heavy metals.     

Transplantation of olfactory ensheathing cells promotes the recovery of neurological functions in rats with traumatic brain injury associated with downregulation of Bad

Background aimsThe neuroprotective effects of olfactory ensheathing cells (OECs) after transplantation have largely been known in the injured nervous system. However, the underlying mechanisms still must be further elucidated. We explored the effects of OEC transplantation on the recovery of neurophysiologic function and the related anti-apoptosis mechanism in acute traumatic brain injury.MethodsThe OECs from neonatal Sprague-Dawley rats were isolated, identified and labeled and then were immediately transplanted into the regions surrounding the injured brain site that is resulted from free-weight drop injury.ResultsNerve growth factor and it's recepor, p75 was expressed in cultured OECs. Transplanted OECs survived, migrated around the injury site and significantly improved the neurological severe scores compared with the control group (P < 0.05). OEC transplantation significantly increased the number of GAP-43–immunopositive fibers and synaptophysin-positive vesicles (P < 0.05) but significantly decreased the number of apoptotic cells (P < 0.05). On the molecular level, the expression of Bad in the OEC transplantation group was significantly downregulated (P < 0.05).ConclusionsOEC transplantation could effectively improve neurological deficits in TBI rats; the underlying mechanism may be related with their effects on neuroprotection and regeneration induction, which is associated with the downregulation of the apoptotic molecule Bad.     

Ceramics From the Highwalker Site: a Study of Late Prehistoric Period Cultural Systematics on the Northwestern Plains

Abstract

The Highwalker site is a two component prehistoric encampment located in the Pine Parklands region of southeastern Montana. The Late Prehistoric period occupation represents a briefly used, special purpose site occupied by a Native American group primarily engaged in the final butchering of bison and the processing of its by-products. Two radiocarbon samples date the Late Prehistoric period occupation between A.D. 1000 and A.D. 1100. Ceramics recovered from this component shed some light on the debate concerning “Crow Pottery” and Late Prehistoric period cultural systematics. The ceramics represent the earliest known representatives of a localized Powder River Basin pottery tradition which appears to be related to Extended Middle Missouri Tradition ceramics. These nomadic Powder River Basin ceramic-using groups maintained contact with the Middle Missouri village farmers and were influenced by their pottery technology. Later when the ethnographically known Crow moved into the area, the Powder River Basin hunting groups either were amalgamated into Crow society or were driven from the area.     

Structure And Evolution Of Calcium-Modulated Protein

Abstract

The question posed by the science of analytical histology is how the properties and interactions of the components of the tissues determine their organization in the organs. The relevant components of the tissues are the cells and the extracellular matrix. The ability of cohering populations of cells to self-assemble structured tissues by cell sorting out offers an important opportunity for the experimental study of the mechanisms by which the cells and extracellular matrix interact to determine structure. The investigator can manipulate the initial organization and the cellular composition of the system and, in favorable situations, the composition of the extracellular matrix and the activities of candidate adhesive molecules.     

Interpopulation Relationships of Four Post-Contact Coalescent Sites From South Dakota:

Abstract

Craniometric comparisons were used to determine tribal affiliation of three Le Beau Phase sites and one Bad River Phase site from South Dakota: Four Bear (39DW2), Oahe Village (39HU2), Swan Creek (39WW7), and Stony Point Village (39ST235). Oahe Village and Swan Creek classified as Arikara in all analyses. Four Bear and Stony Point Village probably also represent Arikara populations although the evidence is less conclusive. Some individuals were assigned to the Mandan in each site. While alternative explanations are possible, those cases may indicate that some Mandan were living in these villages. If Mandan burials are present at Four Bear and Swan Creek, they are not associated with the presence of secondary burials as suggested by Hurt (1957). Arikara populations of the Post-Contact period show considerable variation through time and space.     

The effects of exposure to night shift work on liver function: A cross-sectional study with emphasis of alkaline phosphatase enzyme

ABSTRACT

Background: Previous studies have demonstrated that shift work can be significantly associated with adverse effects on liver function. However, the association between shift work and alkaline phosphatase (ALP) enzyme as a well-known biomarker of liver disease has been undefined. Methods: This cross-sectional study was conducted on a total number of 6,475 eligible oil refinery workers. According to shift work schedules, the participants divided to the following groups: 12-hr rotating night (n = 2,630) and 12-hr fixed day (n = 3845). The Spearman’s correlation and logistic regression were applied to assess the association between shift work and ALP. Results: We found significantly higher levels of ALP in 12-hr rotating night compared to 12-hr fixed-day shift work groups (196.2 ± 52.1 versus 191.5 ± 53.4). According to quartile (Q) logistic regression adjusted by significant variables between study group (age, body mass index, fasting blood sugar, and total cholesterol), the odds ratio and 95% confidence interval of high (Q2–<Q3 versus <Q1) and severe (≥Q3 versus <Q1) levels of ALP in 12-hr rotating night group in comparison to 12-hr fixed-day group were estimated as 1.26 (1.08–1.45) and 1.26 (1.09–1.45), respectively. Conclusions: This study indicated that 12-hr rotating night shift work may be associated with higher levels of ALP. More studies are needed to confirm our findings.     

Eterofillia E Relativa Morfologia in Centaurea Horrida Bad

Summary

The Author points out as the Centaurea horrida Bad., an endemic thorny plant of Sardinia, presents a manifested eterophillia and tries to explain why, among the different Authors, only Moris has evidenced the characteristic; he refers some personal morphological observations on the species and concludes with a new summarized diagnosis of it.     

The Archaeology Of The Breeden Site

Abstract

The Breeden Site cultural sequence reenforcesthe general culture history already established for the Bad-Cheyenne Region and the more inclusive Middle Missouri Tradition. House remains and the bulk of the ceramic materials from the site indicate habitation of the area by peoples of the Initial Middle Missouri Variant and the PostContact Coalescent Variant.Component A at the Breeden Site and the Monroe and Anderson components at the Dodd Site exhibit a complex of diagnosticcultural traits significant enough to define a new phase - the Anderson Phase. A temporal span of approximately A.D. 950to 1250 is suggested for the phase. Component B of the Breeden Site, an early manifestation of the Post-Contract Coalescent Variant, is closely associated with components of the Felicia Phase and the putative Talking Crow Phase. Breeden Component B probably represents an upriver movement of Coalescent peoples from the Big Bend area, eventually being assimilated into the Arikara populations of the Bad River Phase within the Bad-Cheyenne Region.     

Nucleotides. LXXIV Synthesis of a-D-Arabino-oligonucleotides

The 5 α-D-arabinofuranosylnucleosides α-araU (15), α-araT (18), α-araC (22), α-araA (25), and α-araG (28) have been synthesized by the modified silyl-method. The amino groups at the nucleobases and the 2′-hydroxy group at the sugar moiety were protected by the 2-(4-nitro-phenyl) ethoxycarbonyl (npeoc) group (37-40) and the amide function in α-araG was additionally blocked by the 2-(4-nitrophenyl)ethyl group (63) to improve solubility in organic solvents. Mono-and dimethoxytritylation of the 5′-OH group was performed in the usual manner to give 41-48, 64, and 65 in high yields and further substitution of the 3′-OH group led to the monomeric building blocks 66-75 as well as the 3′-O-succinoyl derivatives 76-85 functioning as starting units in solid-support oligonucleotide synthesis. A large number of oligo-α-arabinonucleotides have been prepared on modified CPG-material applying the npeoc/npe strategy as a very efficient synthetic tool for highly purified, homogenous oligomers. Hybridizations between α-arabinonucleotide strands revealed in analogy to earlier findings an antiparallel orientation whereas the combination of an oligo-α-D-arabinonucleotide with a complementary oligo-2′-deoxy-β-D-ribofuranosylnucleotide showed base-pairing only if a parallel polarity was present. The advantages in oligo-α-arabinonucleotide synthesis were furthermore demonstrated by the synthesis of the tα-ANA ^his a structural analog of the natural tRNA ^his of the phage T5.     

On the eigenvalue distribution of genetic and phenotypic dispersion matrices: Evidence for a nonrandom organization of quantitative character variation

A quantitative genetic model of random pleiotropy is introduced as reference model for detecting the kind and degree of organization in quantitative genetic variation. In this model the genetic dispersion matrix takes the form of G = BB ^T, where B is a general, real, Gaussian random matrix. The eigenvalue density of the corresponding ensemble of random matrices (_G) is considered. The first two moments are derived for variance-covariance matrices G as well as for correlation matrices R, and an approximate expression of the density function is given. The eigenvalue distribution of all empirical correlation matrices deviates from that of a random pleiotropy model by a very large leading eigenvalue associated with a size factor. However the frequency-distribution of the remaining eigenvalues shows only minor deviations in mammalian skeletal data. A prevalence of intermediate eigenvalues in insect data may be caused by the inclusion of many functionally unrelated characters. Hence two kinds of deviations from random organization have been found: a mammal like and an insect like organization. It is concluded that functionally related characters are on the average more tightly correlated than by chance (= mammal like organization), while functionally unrelated characters appear to be less correlated than by random pleiotropy (insect like organization).     

Assessment of variation of nest survival for grassland birds due to method of nest discovery

Capsule Interpretation of nest survival estimates may be improved by incorporating the search method used to locate nests as a covariate.

Aims To compare annual survival estimates for Dickcissel Spiza americana nests and determine if incorporating search method (structured, opportunistic, or behavioural searches) improved model fit.

Methods Dickcissel nests were located using structured, opportunistic, or behavioural searches over three years (2011–2013) in Mississippi, USA. Models were used to estimate daily survival rates (DSRs) and to analyse factors influencing nest survival.

Results DSRs for Dickcissels were best explained by quadratic date, nest age, age found, and year, but incorporating search method improved model fit. Daily survival was 1.51 times greater for nests located using opportunistic search methods relative to structured searches, but was not significantly different between structured and behavioural searches.

Conclusions Survival estimates varied by search method, specifically between structured searches and opportunistically located nests. This might have arisen because heterogeneity in nest placement or parental behaviour may influence the sample of nests located with a given search method. Researchers may be able to account for this potential source of bias by including search method as a model covariate when using standard survey designs or modelling approaches.     

CHEMICAL PROPERTIES OF WATER-HOLES IN THE KUISEB RIVER CANYON,NAMIB DESERT

SUMMARY

Five water-holes in the Kuiseb River Canyon, Namib Desert, were monitored over a three month period during the 1977/78 dry season. Apart from the pronounced dominance of Ca(HCO₃)₂ in the water taken from a gorra (water-hole excavated by animals), the chemical composition of the waters analysed was dominated by NaHCO₃ An edaphic origin where the source water had lost its Ca through precipitation of CaCO₃ due to a pH shift is suggested. The saline character of the water-holes is partly ascribed to the input of sea salts through mist rain.     

Shifting perspectives on transnationalism: analysing Dutch political discourse on Moroccan migrants' transnational ties, 1960–2010

Abstract

This article examines the Dutch state's shifting perspectives on migrants' ties with their country of origin. In the academic literature transnationalism was introduced as a neutral term. In political debates the term transnationalism is hardly used, but the ties of migrants with their country of origin (to which the term transnationalism relates) are given a strong negative connotation. They are seen as the main course of failed integration policy. In the past fifty years a dramatic shift has occurred in how these ties are perceived. First, they were regarded positively and were believed to facilitate an easy return of the guest workers. Later they continued to be portrayed positively, but were also considered to be a springboard for integration into Dutch society. Recently they have been portrayed negatively and as the main obstacle to integration. This article explores why this dramatic shift in connotation has occurred.     

Effects of new ways of working on work hours and work location,health and job-related outcomes

ABSTRACT

New ways of working (NWW) is a type of work organization that is characterized by temporal and spatial flexibility, often combined with extensive use of information and communication technologies (ICT) and performance-based management. In a three-wave intervention study, we examined the effects of NWW on both the organization of work (changes in control over time and place of work; working hours and work location; and other key job characteristics), and on employees’ outcomes (work–nonwork balance; health and well-being; and job-related outcomes). We applied a quasi-experimental design within a large Dutch financial company (N = 2,912). We studied an intervention group (n = 2,391) and made comparisons with a reference group (n = 521). There were three study waves: (i) one/two months before, and (ii) 4 months and (iii) 10 months after implementation of NWW. Repeated measures analyses of covariance (involving 361 participants from the intervention group and 80 participants from the reference group) showed a large and significant shift from hours worked at the office to hours worked at home after implementation of NWW. Accordingly, commuting time was reduced. Employees remained working on week days and during day time. Psychosocial work-characteristics, work–nonwork balance, stress, fatigue, and job-related outcomes remained favourable and largely unaffected, but the health score in the intervention group decreased (medium effect). These findings suggest that the implementation of NWW does not necessarily lead to changes in psychosocial work characteristics, well-being or job-related outcomes.     

Effects of work schedule and period of exposure on changes in urinary chromium and nickel excretion among rotating shift workers in a stainless-steel plant

ABSTRACT

We investigated the association between the period of exposure and changes in urinary excretion of chromium and nickel among rotating shift workers in a stainless-steel plant. The study participants were composed of two groups: the workers who were occupationally exposed to metals (“exposed group”) and those who were not occupationally exposed to metals (“unexposed group”). The exposed and unexposed groups consisted of 56 and 40 male rotating shift workers, respectively. Urine samples were collected immediately before and immediately after the day shift, evening shift, and night shift. Urinary chromium and nickel were measured using inductively coupled plasma mass spectrometry. To correct for variations in urine dilution, urinary metal concentrations were expressed as a ratio to urinary creatinine concentration. In the exposed group, post-shift urinary excretion of chromium was significantly higher than pre-shift excretion. However, although urinary chromium excretion clearly increased after the day and night shift [63% (p < .0001) and 87% (p < .0001), respectively], urinary chromium excretion after the evening shift was only slightly higher than that measured before the evening shift (8%, p = .028). Similar patterns were found for urinary nickel excretion (p = .0001, 0.20, and 0.18 for the day, evening, and night shifts, respectively). Non-uniform urinary excretion of metals between the day shift, evening shift, and night shift were observed in the exposed group; specifically, urinary metal excretion increased only slightly during the evening shift. In the unexposed group, no significant increase or decrease was found in median urinary chromium or nickel excretion (p= .63–0.87). Work shift-specific permissible exposure level would be necessary.     

Benthic insects and fish of the Doubs River system: typological traits and the development of a species continuum in a theoretically extrapolated watercourse

Using the distribution patterns of benthic insects (198 species) and fishes ( 29 species) from 11 tributaries and the main channel of the Doubs River drainage basin (French Jura), the authors have tried to establish whether there is an organization of species into discrete, identifiable communities. Principal Component Analysis (PCA) was used to identify whether a continuum existed, and also used to select 50 least-disturbed sites, which were used to define a theoretical watercourse. The density classes of each species were projected on this longitudinal gradient and each species response was characterised by two typological traits: its typological preferendum (tp) and its typological amplitude (ta),thus creating a synthesis of ecological characteristics. In the typological index given in the appendix, the 210 species which form a biological templet are listed in alphabetical order with their tp and ta values. These typological species traits are useful contributions to a database for running waters biomonitoring.