共查询到20条相似文献,搜索用时 15 毫秒
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Amoutzias GD Robertson DL Van de Peer Y Oliver SG 《Trends in biochemical sciences》2008,33(5):220-229
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《Cell cycle (Georgetown, Tex.)》2013,12(14):2731-2739
Comment on: Yang D, et al. Cell Cycle 2010; 9:2789-802. 相似文献
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Coactivators in transcription initiation: here are your orders 总被引:8,自引:0,他引:8
Featherstone M 《Current opinion in genetics & development》2002,12(2):149-155
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Püsküllüoglu M Lukasiewicz E Miekus K Jarocha D Majka M 《Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society》2010,48(4):671-677
Rhabdomyosarcoma (RMS) represents the most common sarcoma of soft tissue among children. Two main RMS subtypes are alveolar (ARMS) and embryonal (ERMS). The major goal of this study was to find differentially expressed genes between RMS subtypes that could explain higher metastatic potential in ARMS and would be useful for the differential diagnosis. Using RQ-PCR analysis we compared expression of Snail1 and Snail-related genes among 7 ARMS and 8 ERMS patients' samples obtained from the primary tumors and among 2 alveolar and 2 embryonal cell lines. Our results show that Snail1 is highly expressed both in ARMS patients' samples and the alveolar cell lines. We also found that the expression of E-Cadherin was downregulated and the expression of Matrix Metalloproteinases 2 and 9 (MMP-2 and MMP-9) was upregulated in ARMS. We assume that, as in many tumors, also in RMS Snail1 acts as a regulator for pathways known for their role in cells' metastasis and that Snail1 activity results in increased MMPs and decreased E-Cadherin expression. Our findings may explain higher ARMS aggressiveness. Moreover, we suggest that further studies should be performed to verify if Snail1 can be considered as a potential target for ARMS therapy. 相似文献
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