共查询到20条相似文献,搜索用时 31 毫秒
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Novel regulation of transcription initiation of the peptide IX gene of adenovirus 2. 总被引:4,自引:1,他引:3
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T Matsui 《Molecular and cellular biology》1989,9(10):4265-4271
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A 10-base-pair element of the human immunodeficiency virus type 1 long terminal repeat (LTR) is an absolute requirement for transactivation by the human cytomegalovirus 72-kilodalton IE1 protein but can be compensated for by other LTR regions in transactivation by the 80-kilodalton IE2 protein. 总被引:14,自引:10,他引:4
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Transient gene expression studies have indicated that human cytomegalovirus (HCMV) specifically transactivates the human immunodeficiency virus (HIV) long terminal repeat (LTR). We show here, by a specific mutational analysis, that only the TATA box region is obligatory for transactivation of the HIV-1 LTR by HCMV. Similarly, this element is also sufficient for transactivation by either the HCMV 72-kDa major immediate-early 1 (IE1) or 80-kDa IE2 gene product independently. However, deletion of a 10-bp region from the minimal responsive element, 5' to the TATA box, dramatically reduced the level of HCMV 72-kDa IE1 or 80-kDa IE2 transactivation, indicating a crucial role for this element in transactivation. Whereas inclusion of the TAR element or Sp1 sites on this 10-bp-deleted minimal promoter had no effect on the removal of IE1 transactivation, TAR and Sp1 elements did compensate for the 10-bp element in transactivation by IE2 and HCMV. Consequently, the sequence requirements of the HIV-1 LTR for transactivation by HCMV can be reproduced by these IE1 and IE2 gene products of HCMV. 相似文献
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The Epstein-Barr virus (EBV) early promoter DR contains a cis-acting element responsive to the EBV transactivator EB1 and an enhancer with constitutive and inducible activities. 总被引:19,自引:15,他引:4
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P Chavrier H Gruffat A Chevallier-Greco M Buisson A Sergeant 《Journal of virology》1989,63(2):607-614
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Transcriptional autorepression of the stress-inducible gene ATF3 总被引:2,自引:0,他引:2
Wolfgang CD Liang G Okamoto Y Allen AE Hai T 《The Journal of biological chemistry》2000,275(22):16865-16870
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