Lessons Learned from Cutting-Edge Immunoinformatics on Next-Generation COVID-19 Vaccine Research

International Journal of Peptide Research and Therapeutics - Presently, immunoinformatics and bioinformatics approaches are contributing actively to COVID-19 vaccine research. The first...     

Progress Toward a Human Vaccine Against Coccidioidomycosis

Coccidioidomycosis (San Joaquin Valley fever) is a human respiratory disease caused by a soil-borne mold, and is recognized as an intransigent microbial infection by physicians who treat patients with the potentially life-threatening, disseminated form of this mycosis. Epidemiological studies based on surveys of skin-test reactivity of people who reside in the endemic regions of the Southwestern US have shown that at least 150,000 new infections occur annually. The clinical spectrum of coccidioidomycosis ranges from an asymptomatic insult to a severe pulmonary disease in which the pathogen may spread from the lungs to the skin, bones, brain and other body organs. Escalation of symptomatic infections and increased cost of long-term antifungal treatment warrant a concerted effort to develop a vaccine against coccidioidomycosis. This review examines recently reported strategies used to generate such a vaccine and summarizes current understanding of the nature of protective immunity to this formidable disease.     

Antibody glycosylation in COVID-19

Glycoconjugate Journal - Antibody glycosylation has received considerable attention in coronavirus disease 2019 (COVID-19) infections and recently also in vaccination. Antibody glycosylation and in...     

Causes of Hypoxemia in COVID-19

Journal of Evolutionary Biochemistry and Physiology - The global pandemic of a new coronavirus disease (COVID-19) has posed challenges to public health specialists around the world associated with...     

COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas

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Chloroquine-induced QTc prolongation in COVID-19 patients

In the battle against the SARS-CoV‑2 pandemic, chloroquine has emerged as a new potential therapeutic option for the treatment of infected patie     

Renin-angiotensin system inhibition in COVID-19 patients

Netherlands Heart Journal - Angiotensin-converting enzyme (ACE) inhibitors (ACEIs) and angiotensin II type?1 receptor blockers (ARBs) are among the most widely prescribed drugs for...     

Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19

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猪链球菌2型疫苗研究进展

猪链球菌2型可引起人、猪急性败血型、脑膜炎型和关节炎型等传染病,致死率极高,是近年来致病性最强、危害性最大的猪链球菌类型之一。目前因该菌的致病机理不清、抗原类型复杂,限制了疫苗研究的顺利进行。当前在研的猪链球菌2型疫苗类型有死疫苗、弱毒苗、蛋白亚单位疫苗等。