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MusTRD can regulate postnatal fiber-specific expression 总被引:1,自引:0,他引:1
Issa LL Palmer SJ Guven KL Santucci N Hodgson VR Popovic K Joya JE Hardeman EC 《Developmental biology》2006,293(1):104-115
Human MusTRD1alpha1 was isolated as a result of its ability to bind a critical element within the Troponin I slow upstream enhancer (TnIslow USE) and was predicted to be a regulator of slow fiber-specific genes. To test this hypothesis in vivo, we generated transgenic mice expressing hMusTRD1alpha1 in skeletal muscle. Adult transgenic mice show a complete loss of slow fibers and a concomitant replacement by fast IIA fibers, resulting in postural muscle weakness. However, developmental analysis demonstrates that transgene expression has no impact on embryonic patterning of slow fibers but causes a gradual postnatal slow to fast fiber conversion. This conversion was underpinned by a demonstrable repression of many slow fiber-specific genes, whereas fast fiber-specific gene expression was either unchanged or enhanced. These data are consistent with our initial predictions for hMusTRD1alpha1 and suggest that slow fiber genes contain a specific common regulatory element that can be targeted by MusTRD proteins. 相似文献
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Myocyte enhancer factor 2A is transcriptionally autoregulated 总被引:1,自引:0,他引:1
Ramachandran B Yu G Li S Zhu B Gulick T 《The Journal of biological chemistry》2008,283(16):10318-10329
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Gene expression of myogenic factors and phenotype-specific markers in electrically stimulated muscle of paraplegics. 总被引:2,自引:0,他引:2
Kristian Vissing Jesper L Andersen Stephen D R Harridge Claudia Sandri Andreas Hartkopp Michael Kjaer Peter Schjerling 《Journal of applied physiology》2005,99(1):164-172
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Tarumi T Kravtsov DV Zhao M Williams SM Gailani D 《The Journal of biological chemistry》2002,277(21):18510-18516
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