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1.
PurposeTo define a method and investigate how the adjustment of scan parameters affected the image quality and Hounsfield units (HUs) on a CT scanner used for radiotherapy treatment planning. A lack of similar investigations in the literature may be a contributing factor in the apparent reluctance to optimise radiotherapy CT protocols.MethodA Catphan phantom was used to assess how image quality on a Toshiba Aquilion LB scanner changed with scan parameters. Acquisition and reconstruction field-of-view (FOV), collimation, image slice thickness, effective mAs per rotation and reconstruction algorithm were varied. Changes were assessed for HUs of different materials, high contrast spatial resolution (HCSR), contrast-noise ratio (CNR), HU uniformity, scan direction low contrast and CT dose-index.ResultsCNR and HCSR varied most with reconstruction algorithm, reconstruction FOV and effective mAs. Collimation, but not image slice width, had a significant effect on CT dose-index with narrower collimation giving higher doses. Dose increased with effective mAs. Highest HU differences were seen when changing reconstruction algorithm: 56 HU for densities close to water and 117 HU for bone-like materials. Acquisition FOV affected the HUs but reconstruction FOV and effective mAs did not.ConclusionsAll the scan parameters investigated affected the image quality metrics. Reconstruction algorithm, reconstruction FOV, collimation and effective mAs were most important. Reconstruction algorithm and acquisition FOV had significant effect on HU. The methodology is applicable to radiotherapy CT scanners when investigating image quality optimisation, prior to assessing the impact of scan protocol changes on clinical CT images and treatment plans.  相似文献   

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PurposeThis work describes PETSTEP (PET Simulator of Tracers via Emission Projection): a faster and more accessible alternative to Monte Carlo (MC) simulation generating realistic PET images, for studies assessing image features and segmentation techniques.MethodsPETSTEP was implemented within Matlab as open source software. It allows generating three-dimensional PET images from PET/CT data or synthetic CT and PET maps, with user-drawn lesions and user-set acquisition and reconstruction parameters. PETSTEP was used to reproduce images of the NEMA body phantom acquired on a GE Discovery 690 PET/CT scanner, and simulated with MC for the GE Discovery LS scanner, and to generate realistic Head and Neck scans. Finally the sensitivity (S) and Positive Predictive Value (PPV) of three automatic segmentation methods were compared when applied to the scanner-acquired and PETSTEP-simulated NEMA images.ResultsPETSTEP produced 3D phantom and clinical images within 4 and 6 min respectively on a single core 2.7 GHz computer. PETSTEP images of the NEMA phantom had mean intensities within 2% of the scanner-acquired image for both background and largest insert, and 16% larger background Full Width at Half Maximum. Similar results were obtained when comparing PETSTEP images to MC simulated data. The S and PPV obtained with simulated phantom images were statistically significantly lower than for the original images, but led to the same conclusions with respect to the evaluated segmentation methods.ConclusionsPETSTEP allows fast simulation of synthetic images reproducing scanner-acquired PET data and shows great promise for the evaluation of PET segmentation methods.  相似文献   

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PurposeTo assess the quality of images obtained on a dual energy computed tomography (CT) scanner.MethodsImage quality was assessed on a 64 detector-row fast kVp-switching dual energy CT scanner (Revolution GSI, GE Medical Systems). The Catphan phantom and a low contrast resolution phantom were employed. Acquisitions were performed at eight different radiation dose levels that ranged from 9 mGy to 32 mGy. Virtual monochromatic spectral images (VMI) were reconstructed in the 40–140 keV range using all available kernels and iterative reconstruction (IR) at four different blending levels. Modulation Transfer Function (MTF) curves, image noise, image contrast, noise power spectrum and contrast to noise ratio were assessed.ResultsIn-plane spatial resolution at the 10% of the MTF curve was 0.60 mm−1. In-plane spatial resolution was not modified with VMI energy and IR blending level. Image noise was reduced from 16.6 at 9 mGy to 6.7 at 32 mGy, while peak frequency remained within 0.14 ± 0.01 mm−1. Image noise was reduced from 14.3 at IR 10% to 11.5 at IR 50% at a constant peak frequency. The lowest image noise and maximum peak frequency were recorded at 70 keV.ConclusionsOur results have shown how objective image quality is varied when different levels of radiation dose and different settings in IR are applied. These results provide CT operators an in depth understanding of the imaging performance characteristics in dual energy CT.  相似文献   

4.
Introduction: CT automatic exposure control (AEC) systems have significant impact on patient dosimetry in modern CT systems. However a reliable method for assessment of AEC systems has not been established as part of quality assurance protocols.Methods: Six systems were assessed from three different vendors (1 GE, 4 Siemens, 1 Philips) using the CeLT phantom. The CeLT phantom (Medical Physics, BCUHB, Wales) consists of four water filled elliptical sections of varying diameters with four CT  相似文献   

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PurposeTo investigate the image quality characteristics for virtual monoenergetic images compared with conventional tube-voltage image with dual-layer spectral CT (DLCT).MethodsHelical scans were performed using a first-generation DLCT scanner, two different sizes of acrylic cylindrical phantoms, and a Catphan phantom. Three different iodine concentrations were inserted into the phantom center. The single-tube voltage for obtaining virtual monoenergetic images was set to 120 or 140 kVp. Conventional 120- and 140-kVp images and virtual monoenergetic images (40–200-keV images) were reconstructed from slice thicknesses of 1.0 mm. The CT number and image noise were measured for each iodine concentration and water on the 120-kVp images and virtual monoenergetic images. The noise power spectrum (NPS) was also calculated.ResultsThe iodine CT numbers for the iodinated enhancing materials were similar regardless of phantom size and acquisition method. Compared with the iodine CT numbers of the conventional 120-kVp images, those for the monoenergetic 40-, 50-, and 60-keV images increased by approximately 3.0-, 1.9-, and 1.3-fold, respectively. The image noise values for each virtual monoenergetic image were similar (for example, 24.6 HU at 40 keV and 23.3 HU at 200 keV obtained at 120 kVp and 30-cm phantom size). The NPS curves of the 70-keV and 120-kVp images for a 1.0-mm slice thickness over the entire frequency range were similar.ConclusionVirtual monoenergetic images represent stable image noise over the entire energy spectrum and improved the contrast-to-noise ratio than conventional tube voltage using the dual-layer spectral detector CT.  相似文献   

7.
IntroductionA mathematical 3D model of an existing computed tomography (CT) scanner was created and used in the EGSnrc-based BEAMnrc and egs_cbct Monte Carlo codes. Simulated transmission dose profiles of a RMI-465 phantom were analysed to verify Hounsfield numbers against measured data obtained from the CT scanner.Methods and materialsThe modelled CT unit is based on the design of a Toshiba Aquilion 16 LB CT scanner. As a first step, BEAMnrc simulated the X-ray tube, filters, and secondary collimation to obtain phase space data of the X-ray beam. A bowtie filter was included to create a more uniform beam intensity and to remove the beam hardening effects. In a second step the Interactive Data Language (IDL) code was used to build an EGSPHANT file that contained the RMI phantom which was used in egs_cbct simulations. After simulation a series of profiles were sampled from the detector model and the Feldkamp-Davis-Kress (FDK) algorithm was used to reconstruct transversal images. The results were tested against measured data obtained from CT scans.ResultsThe egs_cbct code can be used for the simulation of a fan beam CT unit. The calculated bowtie filter ensured a uniform flux on the detectors. Good correlation between measured and simulated CT numbers was obtained.ConclusionsIn principle, Monte Carlo codes such as egs_cbct can model a fan beam CT unit. After reconstruction, the images contained Hounsfield values comparable to measured data.  相似文献   

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PurposeFeasability of a no-reference image quality metric was assessed on patient-like images using a patient-specific phantom simulating a frame of a coronary angiogram.MethodsOne background and one contrast-filled frame of a coronary angiogram, acquired using a clinical imaging protocol, were selected from a Philips Integris Allura FD (Philips Healthcare, Best, The Netherlands). The background frame’s pixels were extruded to a thickness proportional to their grey value. One phantom was 3D printed using composite 80% bronze filament (max. thickness of 5.1 mm), the other was a custom PMMA cast (max thickness of 8.5 cm). A vessel mold was created from the contrast-filled frame and injected with a solution of 320 mg I/ml contrast fluid (75%), water and gelatin. Still X-ray frames of the vessel mold + background phantom + 16 cm PMMA were acquired at manually selected different exposure settings using a Philips Azurion (Philips Healthcare, Best, The Netherlands) in User Quality Control Mode and were exported as RAW images. The signal-difference-to-noise-ratio-squared (SDNR2) and a spatial-domain-equivalent of the noise equivalent quanta (NEQSDE) were calculated. The Spearman’s correlation of the latter parameters with a no-reference perceptual image quality metric (NIQE) was investigated.ResultsThe bronze phantom showed better resemblance to the original patient frame selected from a coronary angiogram of an actual patient, with better contrast and less blur than the PMMA phantom. Both phantoms were imaged using a comparable imaging protocol to the one used to acquire the original frame. The bronze phantom was hence used together with the vessel mold for image quality measurements on the 165 still phantom frames. A strong correlation was noted between NEQSDE and NIQE (SROCC = –0.99, p < 0.0005) and between SDNR2 and NIQE (SROCC = –0.97, p < 0.0005).ConclusionUsing a cost-effective and easy to realize patient-specific phantom we were able to generate patient-like X-ray frames. NIQE as a no-reference image quality model has the potential to predict physical image quality from patient images.  相似文献   

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目的:评价智能期相选择(Smart phase)和自动追踪冻结(Snap-Shot-Freeze, SSF)技术联合应用在前门控冠状动脉CT血管成像(Coronary CT angiography, CCTA)改善图像运动伪影中的价值。方法:94例疑似心血管疾病的患者行CCTA检查。所有患者图像均采用smart phase、SSF及smart phase+SSF两种技术联合进行后处理。将原始图像(A组)、smart phase图像(B组)、SSF图像(C组)和smart phase+SSF图像(D组)导入GE AW4.6工作站。对四组患者冠状动脉三大分支(右冠状动脉、左前降支及左旋支)图像质量进行主观评价(5分法)和测量每组图像主动脉根部及前胸壁肌肉CT值和标准差,并计算图像的噪声(Noise,N)、信噪比(Signal-to-noise ratio,SNR)和对比噪声比(Contrast-to-noise ratio,CNR)和比较。结果:经smart phase处理后,A组冠状动脉三大分支图像评分均得到了明显提高(P<0.05)。经SSF矫正的A组和B组冠状动脉三大分支图像质量评分均得到明显提高(P<0.05)。Smart Phase联合SSF技术得到的图像评分在所有组中评分最高,与其他组均存在显著差异(P<0.05)。结论:Smart phase联合SSF技术可明显改善前门控CCTA图像运动伪影,值得临床推广应用。  相似文献   

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PurposeThis paper describes the hardware and software characteristics of a 3D optical scanner (P3DS) developed in-house. The P3DS consists of an LED light source, diffuse screen, step motor, CCD camera, and scanner management software with 3D reconstructed software.Materials and methodWe performed optical simulation, 2D and 3D reconstruction image testing, and pre-clinical testing for the P3DS. We developed the optical scanner with three key characteristics in mind. First, we developed a continuous scanning method to expand possible clinical applications. Second, we manufactured a collimator to improve image quality by reducing scattering from the light source. Third, we developed an optical scanner with changeable camera positioning to enable acquisition of optimal images according to the size of the gel dosimeter.ResultsWe confirmed ray-tracing in P3DS with optic simulation and found that 2D projection and 3D reconstructed images were qualitatively similar to the phantom images. For pre-clinical tests, the dose distribution and profile showed good agreement among RTP, optical CT, and external beam radiotherapy film data for the axial and coronal views. The P3DS has shown that it can scan and reconstruct for evaluation of the gel dosimeter within 1 min. We confirmed that the P3DS system is a useful tool for the measurement of 3D dose distributions for 3D radiation therapy QA. Further experiments are needed to investigate quantitative analysis for 3D dose distribution.  相似文献   

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PurposeTo measure the combined errors due to geometric inaccuracy and image co-registration on secondary images (dynamic CT angiography (dCTA), 3D DynaCT angiography (DynaCTA), and magnetic resonance images (MRI)) that are routinely used to aid in target delineation and planning for stereotactic radiosurgery (SRS).MethodsThree phantoms (one commercial and two in-house built) and two different analysis approaches (commercial and MATLAB based) were used to quantify the magnitude of geometric image distortion and co-registration errors for different imaging modalities within CyberKnife’s MultiPlan treatment planning software. For each phantom, the combined errors were reported as a mean target registration error (TRE). The mean TRE’s for different intramodality imaging parameters (e.g., mAs, kVp, and phantom set-ups) and for dCTA, DynaCTA, and MRI systems were measured.ResultsOnly X-ray based imaging can be performed with the commercial phantom, and the mean TRE ± standard deviation values were large compared to the in-house analysis using MATLAB. With the 3D printed phantom, even drastic changes in treatment planning CT imaging protocols did not greatly influence the mean TRE (<0.5 mm for a 1 mm slice thickness CT). For all imaging modalities, the largest mean TRE was found on DynaCT, followed by T2-weighted MR images (albeit all <1 mm).ConclusionsThe user may overestimate the mean TRE if the commercial phantom and MultiPlan were used solely. The 3D printed phantom design is a sensitive and suitable quality assurance tool for measuring 3D geometric inaccuracy and co-registration errors across all imaging modalities.  相似文献   

13.
PurposeTo study normal lung tissue (NLT) complications in magnetic resonance (MR) image based linac and conventional radiotherapy (RT) techniques.Materials and MethodsThe Geant4 toolkit was used to simulate a 6 MV photon beam. A homogenous magnetic field of 1.5 Tesla (T) was applied in both perpendicular and parallel directions relative to the radiation beam.Analysis of the NLT complications was assessed according to the normal lung tissue complication probability (NTCP), the mean lung dose (MLD), and percentage of the lung volume receiving doses greater than 20 Gy (V20), using a sample set of CT images generated from a commercially available 4D-XCAT digital phantom.ResultsThe results show that the MLD and V20 were lower for MR-linac RT. The largest reduction of MLD and V20 for MR-linac RT configurations were 5 Gy and 29.3%, respectively.ConclusionMR-linac RT may result in lower NLT complications when compared to conventional RT.  相似文献   

14.
Aim of the study was to evaluate the performance of a tube current modulation (TCM) system (SUREExposure 3D).On a 64 detector-row CT scanner (Aquilion 64, Toshiba), performance of fixed tube current, longitudinal TCM, and volumetric TCM acquisitions were assessed. A homogeneous cone-shaped phantom and an anthropomorphic phantom were used. Tube current and noise profiles were quantitatively analysed by box and whisker plots when phantom size, acquisition, and reconstruction parameters were varied.At similar median noise, fixed tube current scanning showed a noise range of 16.8–38.3 HU, while longitudinal TCM showed a range of 19.4–31.4 HU and volumetric TCM showed an even lower range of 20.7–28.7 HU. When acquisitions resulting in similar image quality (noise) were compared, the use of volumetric compared to longitudinal TCM resulted in a variable radiation dose reduction up to 6.6%.In conclusion, SUREExposure 3D resulted in more uniform image quality at a lower dose. Volumetric TCM shows improved results over longitudinal TCM.  相似文献   

15.
PurposeTo compare the effective dose (ED) and image quality (IQ) of O-arm cone-beam CT (Medtronic, Minneapolis, MN, USA) and Airo multi-slice CT (Brainlab AG, Munich, Germany) for intraoperative-CT (i-CT) in spinal surgery.MethodsThe manufacturer-defined protocols available in the O-arm and Airo systems for three-dimensional lumbar spine imaging were compared.Organ dose was measured both with thermo-luminescent dosimeters and GafChromic films in the Alderson Radiation Therapy anthropomorphic phantom.A subjective analysis was performed by neurosurgeons to compare the clinical IQ of the anthropomorphic phantom images acquired with the different i-CT systems and imaging protocols.Image uniformity, noise, contrast-to-noise-ratio (CNR), and spatial resolution were additionally assessed with the Catphan 504 phantom.ResultsO-arm i-CT caused 56% larger ED than Airo due to the high definition (HD) imaging protocol.The noise was larger for O-arm images leading to a lower CNR than that measured for Airo. Moreover, scattering and beam hardening effects were observed in the O-arm images. Better spatial resolution was measured for the O-arm system (9 lp/cm) than for Airo (4 lp/cm).For all the investigated protocols, O-arm was found to be better for identifying anatomical features important for accurate pedicle screw positioning.ConclusionsAccording to phantom measurements, the HD protocol of O-arm offered better clinical IQ than Airo but larger ED. The larger noise of O-arm images did not compromise the clinical IQ while the superior spatial resolution of this system allowed a better visibility of anatomical features important for pedicle screw positioning in the lumbar region.  相似文献   

16.
PurposeTo show the usefulness of topographic 2D megavoltage images (MV2D) for the localization of breast cancer patients treated with TomoDirect (TD), a radiotherapy treatment technique with fixed-angle beams performed on a TomoTherapy system.MethodsA method was developed to quickly localize breast cancer patients treated with TD by registering the MV2D images produced before a TD treatment with reference images reconstructed from a kilovoltage CT simulation scanner and by using the projection of the beam-eye-view TD treatment field. Dose and image quality measurements were performed to determine the optimal parameters for acquiring MV2D images. A TD treatment was simulated on a chest phantom equipped with a breast attachment. MVCT and MV2D images were performed for 7 different shifted positions of the phantom and registered by 10 different operators with the simulation kilovoltage CT images.ResultsCompared to MVCT, MV2D imaging reduces the dose by a factor of up to 45 and the acquisition time by a factor of up to 49. Comparing the registration shift values obtained for the phantom images obtained with MVCT in the coarse mode to those obtained with MV2D, the mean difference is 1.0 ± 1.1 mm, −1.1 mm ± 1.1, and −0.1 ± 2.2 mm, respectively, in the lateral, longitudinal, and vertical directions.ConclusionsWith dual advantages (very fast imaging and a potentially reduced dose to the heart and contralateral organs), MV2D topographic images may be an attractive alternative to MVCT for the localization of breast cancer patients treated with TomoDirect.  相似文献   

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PurposeBased on the guidelines from “Report 87: Radiation Dose and Image-quality Assessment in Computed Tomography” of the International Commission on Radiation Units and Measurements (ICRU), a software framework for automated quantitative image quality analysis was developed and its usability for a variety of scientific questions demonstrated.MethodsThe extendable framework currently implements the calculation of the recommended Fourier image quality (IQ) metrics modulation transfer function (MTF) and noise-power spectrum (NPS), and additional IQ quantities such as noise magnitude, CT number accuracy, uniformity across the field-of-view, contrast-to-noise ratio (CNR) and signal-to-noise ratio (SNR) of simulated lesions for a commercially available cone-beam phantom. Sample image data were acquired with different scan and reconstruction settings on CT systems from different manufacturers.ResultsSpatial resolution is analyzed in terms of edge-spread function, line-spread-function, and MTF. 3D NPS is calculated according to ICRU Report 87, and condensed to 2D and radially averaged 1D representations. Noise magnitude, CT numbers, and uniformity of these quantities are assessed on large samples of ROIs. Low-contrast resolution (CNR, SNR) is quantitatively evaluated as a function of lesion contrast and diameter. Simultaneous automated processing of several image datasets allows for straightforward comparative assessment.ConclusionsThe presented framework enables systematic, reproducible, automated and time-efficient quantitative IQ analysis. Consistent application of the ICRU guidelines facilitates standardization of quantitative assessment not only for routine quality assurance, but for a number of research questions, e.g. the comparison of different scanner models or acquisition protocols, and the evaluation of new technology or reconstruction methods.  相似文献   

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PurposeTo experimentally investigate the effect of the scan field of view (SFOV) selection and table height settings on the Computed Tomography Dose Index (CTDI) and the implications concerning patient effective and skin dose.MethodsAir-kerma length product (AKLP) measurements were carried out in a helical CT scanner using a pencil type dosimeter positioned in air and inside the holes of a head and a body phantom, using all available SFOV selections and different table height settings. Furthermore, using radiotherapy verification films placed on the CT table surface, the entrance surface air kerma (ESAK) profiles were derived with different SFOV and table height selections, both with and without a phantom on top of the films.ResultsThe AKLP is strongly dependent on the SFOV selection and the table height settings. Different SFOV selections correspond to the selection of different bowtie filters that shape the X-ray beam intensity, resulting in different ESAK values at the isocenter and at the other points within the scanning plane. With the off-center positioning the calculated CTDI values within the center and the periphery of the phantom change also, as a result of the different intensity and width of the X-ray beam to which are exposed to.ConclusionsThe existing protocols for calculating effective dose are limited to only two patient anatomy-SFOV combinations and cannot account for off-center positioning. Therefore, more work will be required to estimate the effective and skin dose for non-standard SFOV-patient anatomy combinations and off-center patient positioning.  相似文献   

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PurposeArm-artifact, a type of streak artifact frequently observed in computed tomography (CT) images obtained at arms-down positioning in polytrauma patients, is known to degrade image quality. This study aimed to develop a novel arm-artifact reduction algorithm (AAR) applied to projection data.MethodsA phantom resembling an adult abdomen with two arms was scanned using a 16-row CT scanner. The projection data were processed by AAR, and CT images were reconstructed. The artifact reduction for the same phantom was compared with that achieved by two latest iterative reconstruction (IR) techniques (IR1 and IR2) using a normalized artifact index (nAI) at two locations (ventral and dorsal side). Image blurring as a processing side effect was compared with IR2 of the model-based IR using a plastic needle phantom. Additionally, the projection data of two clinical cases were processed using AAR, and the image noise was evaluated.ResultsAAR and IR2 significantly reduced nAI by 87.5% and 74.0%, respectively at the ventral side and 84.2% and 69.6%, respectively, at the dorsal side compared with each filtered back projection (P < 0.01), whereas IR1 did not. The proposed algorithm mostly maintained the original spatial resolution, compared with IR2, which yielded apparent image blurring. The image noise in the clinical cases was also reduced significantly (P < 0.01).ConclusionsAAR was more effective and superior than the latest IR techniques and is expected to improve the image quality of polytrauma CT imaging with arms-down positioning.  相似文献   

20.
PurposeWe used pediatric and adult anthropomorphic phantoms to compare the radiation dose of low- and standard tube voltage chest and abdominal non-contrast-enhanced computed tomography (CT) scans. We also discuss the optimal low tube voltage for non-contrast-enhanced CT.MethodsUsing a female adult- and three differently-sized pediatric anthropomorphic phantoms we acquired chest and abdominal non-contrast-enhanced scans on a 320-multidetector CT volume scanner. The tube voltage was set at 80-, 100-, and 120 kVp. The tube current was automatically assigned on the CT scanner in response to the set image noise level. On each phantom and at each tube voltage we measured the surface and center dose using high-sensitivity metal-oxide-semiconductor field-effect transistor detectors.ResultsThe mean surface dose of chest and abdominal CT scans in 5-year olds was 4.4 and 5.3 mGy at 80 kVp, 4.5 and 5.4 mGy at 100 kV, and 4.0 and 5.0 mGy at 120 kVp, respectively. These values were similar in our 3-pediatric phantoms (p > 0.05). The mean surface dose in the adult phantom increased from 14.7 to 19.4 mGy for chest- and from 18.7 to 24.8 mGy for abdominal CT as the tube voltage decreased from 120 to 80 kVp (p < 0.01).ConclusionCompared to adults, the surface and center dose for pediatric patients is almost the same despite a decrease in the tube voltage and the low tube voltage technique can be used for non-contrast-enhanced chest- and abdominal scanning.  相似文献   

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