共查询到20条相似文献,搜索用时 15 毫秒
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Marasa BS Xiao L Rao JN Zou T Liu L Wang J Bellavance E Turner DJ Wang JY 《American journal of physiology. Cell physiology》2008,294(5):C1277-C1287
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Signaling via NF-kappaB in the nervous system 总被引:4,自引:0,他引:4
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The role of hydroxyl radical as a messenger in the activation of nuclear transcription factor NF-κB 总被引:2,自引:0,他引:2
Shi Xianglin Dong Zigang Huang Chuanshu Shi Xianglin Ma Wiya Liu Kejian Chen Fei Leonard Stephen S. Ding Min Castranova Vince Vallyathan Val 《Molecular and cellular biochemistry》1999,194(1-2):63-70
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Studies in transgenic and knockout mice have made a major contribution to our current understanding of the physiological functions of the NF-kappaB signalling cascade. The generation and analysis of mice with targeted modifications of individual components of the NF-kappaB pathway tremendously advanced our knowledge of the roles of the NF-kappaB proteins themselves, and also of the many activators and negative regulators of NF-kappaB. These studies have highlighted the complexity of the NF-kappaB system, by revealing the multiple interactions, redundancies, but also diverse functions, performed by the different molecules participating in the regulation of NF-kappaB signalling. Furthermore, inhibition or enforced activation of NF-kappaB in transgenic mice has uncovered the critical roles that NF-kappaB plays in the pathogenesis of various diseases such as liver failure, diabetes and cancer. 相似文献
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Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras 总被引:1,自引:0,他引:1
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IkappaBbeta, one of the major IkappaB proteins, is only partially degraded in response to most extracellular signals. However, the molecular mechanism of this event is unknown. We show here that IkappaBbeta exists in at least two different forms: one that is bound to the NF-kappaB dimer and the other bound to both NF-kappaB and kappaB-Ras, a Ras-like small G protein. Removal of cellular kappaB-Ras enhances whereas excess kappaB-Ras blocks induced IkappaBbeta degradation. Remarkably, kappaB-Ras functions in both GDP- and GTP-bound states, and mutations of the conserved guanine-binding residues of kappaB-Ras abrogate its ability to block degradation of IkappaBbeta. kappaB-Ras also directly blocks the in vitro phosphorylation of IkappaBbeta by IKKbeta. These observations suggest that IkappaBbeta in the ternary complex is resistant to degradation by most signals. We suggest that specific signals, in addition to those that activate only IKK, are essential for the complete degradation of IkappaBbeta. 相似文献