Systematic comparison of family history and polygenic risk across 24 common diseases

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Polygenic risk prediction: why and when out-of-sample prediction R2 can exceed SNP-based heritability

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Autoimmune alleles at the major histocompatibility locus modify melanoma susceptibility

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Global Burden of Disease Study 2019 suggests that metabolic risk factors are the leading drivers of the burden of ischemic heart disease

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Fast and accurate Bayesian polygenic risk modeling with variational inference

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Genotype error due to low-coverage sequencing induces uncertainty in polygenic scoring

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Genomic architecture of autism from comprehensive whole-genome sequence annotation

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Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity

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Developmental and temporal characteristics of clonal sperm mosaicism

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A rodent herbivore reduces its predation risk through ecosystem engineering

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Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial

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The infant gut resistome associates with E. coli,environmental exposures,gut microbiome maturity,and asthma-associated bacterial composition

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Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures

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Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel

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Mouse population genetics phenocopies heterogeneity of human Chd8 haploinsufficiency

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Combined CRISPRi and proteomics screening reveal a cohesin-CTCF-bound allele contributing to increased expression of RUVBL1 and prostate cancer progression

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Quantitative evaluation of chromosomal rearrangements in gene-edited human stem cells by CAST-Seq

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A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants

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Identification and single-base gene-editing functional validation of a cis-EPO variant as a genetic predictor for EPO-increasing therapies

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The Circadian Clock Gene Circuit Controls Protein and Phosphoprotein Rhythms in Arabidopsis thaliana

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