What is complex about complex disorders?

Rather than being polygenic, complex disorders probably represent umbrella terms for collections of conditions caused by rare, recent mutations in any of a large number of different genes.     

What is 'public opinion' about genetics?

Every biotechnology success story increases the number of decisions that the lay public must make about genetics. But vibrant public discussion about these far-reaching changes has been rare, and research on the public's understanding of genetics has barely scratched the surface. This article reviews what we know about the public's attitudes towards genetics, proposes some concepts for thinking about public involvement and indicates some future lines of research.     

What is optimal about motor control?

This article poses a controversial question: is optimal control theory useful for understanding motor behavior or is it a misdirection? This question is becoming acute as people start to conflate internal models in motor control and perception (Poeppel et?al., 2008; Hickok et?al., 2011). However, the forward models in motor control are not the generative models used in perceptual inference. This Perspective tries to highlight the differences between internal models in motor control and perception and asks whether optimal control is the right way to think about things. The issues considered here may have broader implications for optimal decision theory and Bayesian approaches to learning and behavior in general.     

What is paradoxical about Levinthal paradox?

We would be tempted to state that there has never been a Levinthal paradox. Indeed, Levinthal raised an interesting problem about protein folding, as he realized that proteins have no time to explore exhaustively their conformational space on the way to their native structure. He did not seem to find this paradoxical and immediately proposed a straightforward solution, which has essentially never been refuted. In other words, Levinthal solved his own paradox.     

What is "epi" about epigenetics?

What counts as epigenetic depends on what counts as genetic. It is argued that Weismannism, the doctrine of genetic continuity and somatic discontinuity, is the basis for an overly inclusive concept of epigenetics as every inherited resource < beyond the genes >. An alternative theoretical perspective, the < reproducer > concept, facilitates analysis of multiple inheritance systems without labeling all non-genetic inheritance < epigenetic >.     

Placebos and painkillers: is mind as real as matter?

Considerable progress has been made in our understanding of the neurobiological mechanisms of the placebo effect, and most of our knowledge originates from the field of pain and analgesia. Today, the placebo effect represents a promising model that could allow us to shed new light on mind-body interactions. The mental events induced by placebo administration can activate mechanisms that are similar to those activated by drugs, which indicates a similarity between psychosocial and pharmacodynamic effects. These new neurobiological advances are already changing our conception of how clinical trials and medical practice must be viewed and conducted.     

Animal morality: What is the debate about?

Empirical studies of the social lives of non-human primates, cetaceans, and other social animals have prompted scientists and philosophers to debate the question of whether morality and moral cognition exists in non-human animals. Some researchers have argued that morality does exist in several animal species, others that these species may possess various evolutionary building blocks or precursors to morality, but not quite the genuine article, while some have argued that nothing remotely resembling morality can be found in any non-human species. However, these different positions on animal morality generally appear to be motivated more by different conceptions of how the term “morality” is to be defined than by empirical disagreements about animal social behaviour and psychology. After delving deeper into the goals and methodologies of various of the protagonists, I argue that, despite appearances, there are actually two importantly distinct debates over animal morality going on, corresponding to two quite different ways of thinking about what it is to define “morality”, “moral cognition”, and associated notions. Several apparent skirmishes in the literature are thus cases of researchers simply talking past each other. I then focus on what I take to be the core debate over animal morality, which is concerned with understanding the nature and phylogenetic distribution of morality conceived as a psychological natural kind. I argue that this debate is in fact largely terminological and non-substantive. Finally, I reflect on how this core debate might best be re-framed.     

Antisense therapeutics: is it as simple as complementary base recognition?

Antisense oligonucleotides provide a simple and efficient approach for developing target-selective drugs because they can modulate gene expression sequence-specifically. Antisense oligonucleotides have also become efficient molecular biological tools to investigate the function of any protein in the cell. As the application of antisense oligonucleotides has expanded, multiple mechanisms of oligonucleotides have been characterized that impede their routine use. Here, we discuss different mechanisms of action of oligonucleotides and the possible ways of minimizing non-antisense-related [corrected] effects to improve their specificity.     

Phosphorothioate oligodeoxynucleotides: what is their origin and what is unique about them?

The development of nucleoside phosphorothioates is described in its historical context. Examples of the interaction of phosphorothioate groups, present either in oligodeoxynucleotides or in DNA, with nucleases are presented. The structural features responsible for the resistance of the phosphorothioates toward degradation by nucleases are discussed, as are the possible reasons for the high-affinity interaction of phosphorothioate oligodeoxynucleotides with certain proteins.     

What is known about phytohormones in halophytes? A review

Phytohormones participate in many aspects of the plant life cycle, including responses to biotic and abiotic stresses. They play a key role in plant responses to the environment with direct bearing on a plant’s fitness for adaptation and reproduction. In recent years, there have been major advances in our understanding of the role of phytohormones in halophytic plants. The variability in maximal salinity level that halophytes can tolerate makes it difficult to characterize the specific traits responsible for salt tolerance. However, the most evident effect of salinity is growth disturbance, and growth is directly governed by phytohormones. Phytohormones such as abscisic acid, salicylic acid ethylene and jasmonates are traditionally related to stress responses, while the involvement of cytokinins, gibberellins and auxins has started to be analyzed. Polyamines, although they can’t be considered phytohormones because of the high concentrations required for cell responses, have been proposed as a new category of plant growth regulators involved in several plant processes and stress responses. This review integrates the advances in the knowledge about phytohormones in halophytes and their participation in salt tolerance.     

The millennium ecosystem assessment: what is it all about?

Hundreds of scientists from over 70 nations are now engaged in an intensive effort to assess what we know about the status of the world's ecosystems. Here, we describe the fundamental nature of this assessment, what it hopes to accomplish and how it will go about its work. The results of the Millennium Ecosystem Assessment will serve as a baseline for future assessments, as well as a blueprint for action for sustaining the ecosystem services upon which we all depend for our well being.     

Xenotransplantation: is the risk of viral infection as great as we thought?

Two major hurdles remain before xenotransplantation can enter the clinic. The first is the more technical issue of being able to overcome the human immune response that leads to rejection of transplanted organs/cells from other species. The second, reviewed here, concerns the potential risk of inadvertent transfer of animal viruses present in the xenotransplant that are able to infect the human recipient. The threat from viruses is a particularly contentious topic because it poses a risk not only to those individuals who receive xenotransplants, but also to healthy individuals who come into contact, either directly or indirectly, with the xenotransplant recipient. In this review, we describe some of the virus types, in addition to the much discussed porcine endogenous retroviruses that might cross the species barrier, and assess the risk of such viruses causing disease in human hosts.